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Ling Ding @bcdingling

Natural product chemist, associate professor at Technical University of Denmark

Joined December 2017
  • Tweets 92
  • Following 101
  • Followers 411
10 Photos and videos
Ling Ding@bcdingling
21 Dec 2024
Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus biorxiv.org/content/10.1101/…

Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus

Nyuzenamides belong to the class of bioactive cinnamoyl moiety containing non-ribosomal peptides (NRPs). However, their biosynthetic gene cluster (BGC) remains unconfirmed. Genome-mining revealed a...

biorxiv.org
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HEMANT ALONE@AloneHemant
2 Nov 2024
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Winter is approaching and it is time to get busier to store enough food.
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Our work in using bacterial metabolites help crops grow better under abiotic stresses. dtu.dk/english/news/all-news…

Soil bacteria to make crops resistant to salt and drought

Worldwide farmers are experiencing reduced yields due to conditions such as drought and increased salinity, that are only intensified by more frequent and extreme climate events. DTU start-up,...

dtu.dk
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Ling Ding@bcdingling
27 Oct 2024
Fighting AMR by the antifungal drug candidate alligamycin communities.springernature.c… @tilmweber @zhijie_zj #antibiotics#AMR#Aspergillus#antimicrobial#

Fighting AMR by the antifungal drug candidate alligamycin

Invasive fungal pathogens cause 3.8 millions of death worldwide. There are only four main classes of antifungal drugs and they are limited by toxicity, drug-drug interactions and antibiotic resista...

communities.springernature.com
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Ling Ding@bcdingling
26 Oct 2024
Invasive fungal infections kill 3.8 millions of deaths annually. Current antifungal medicines are limited by toxicity, drug-drug interactions and resistance. We report alligamycin as a novel antifungal lead against resistant Aspergillus and Talaromyces. nature.com/articles/s41467-0…

Alligamycin A, an antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

Nature Communications - From the rapamycin-producer Streptomyces iranensis, authors report on the discovery of the antifungal candidate alligamycin A, which exhibited strong activities against...

nature.com
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Huiluo Cao 曹慧荦@hlcao
22 Oct 2024
Systematic discovery of antibacterial and antifungal bacterial toxins | Nature Microbiology nature.com/articles/s41564-0…

Systematic discovery of antibacterial and antifungal bacterial toxins

Nature Microbiology - Genome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi.

nature.com
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Huiluo Cao 曹慧荦@hlcao
20 Sep 2024
Antimicrobial resistance: a concise update - The Lancet Microbe thelancet.com/journals/lanmi…

Antimicrobial resistance: a concise update

Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and...

thelancet.com
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We are looking for a passionate natural product chemist. Please check out the position here. efzu.fa.em2.oraclecloud.com/…
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Ling Ding@bcdingling
27 May 2024
We have an open position for a PhD in natural product chemistry. efzu.fa.em2.oraclecloud.com/…

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Ling Ding@bcdingling
19 May 2024
Long weekend with a long bike tour in the beautiful nature😂
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Huiluo Cao 曹慧荦@hlcao
14 May 2024
Bacteriocin diversity, function, discovery and application as antimicrobials | Nature Reviews Microbiology nature.com/articles/s41579-0…

Bacteriocin diversity, function, discovery and application as antimicrobials

Nature Reviews Microbiology - In this Review, Sugrue, Ross and Hill explore recent developments in bacteriocin research, including new discoveries and bioengineering approaches for improved...

nature.com
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Ling Ding@bcdingling
14 May 2024
Check our recent publication on heterologous expression of a bifunctional enzyme pubs.acs.org/doi/full/10.102…

Maramycin, a Cytotoxic Isoquinolinequinone Terpenoid Produced through Heterologous Expression of a...

Isoquinolinequinones represent an important family of natural alkaloids with profound biological activities. Heterologous expression of a rare bifunctional indole prenyltransferase/tryptophan...

pubs.acs.org
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Ling Ding@bcdingling
22 Apr 2024
Compounds belonging to ansamycins, e.g., rifamycins are an important class of natural products. Here we report new hygrocins from the rapamycin-producer S. hygroscopicus. pubs.acs.org/doi/full/10.102…

Genome-Driven Discovery of Hygrocins in Streptomyces rapamycinicus

Ansamycins, represented by the antituberculosis drug rifamycin, are an important family of natural products. To obtain new ansamycins, Streptomyces rapamycinicus IMET 43975 harboring an ansamycin...

pubs.acs.org
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Ling Ding@bcdingling
18 Apr 2024
Spirolactone, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis biorxiv.org/content/10.1101/…

Spirolactone, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

Fungal infections pose a great threat to public health. There are only four classes of antifungals that have limitations due to high toxicity, drug-drug interactions, and emerging drug-resistance....

biorxiv.org
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Ling Ding@bcdingling
12 Apr 2024
Azoxyl compounds are a group of natural toxins. Interested in their biosynthesis? Here comes our recent work. pubs.acs.org/doi/10.1021/acs…

Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2

Azoxy compounds are a distinctive group of bioactive secondary metabolites characterized by a unique RN═N (O–)R moiety. The azoxy moiety is present in various classes of metabolites that exhibit...

pubs.acs.org
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Ling Ding@bcdingling
12 Apr 2024
Our paper on access to pepticinnamins by inactivation of the azodyrecin BGC. pubs.acs.org/doi/full/10.102…

Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2

Cinnamoyl moiety containing nonribosomal peptides represented by pepticinnamin E are a growing family of natural products isolated from different Streptomyces species and possess diverse bioactivit...

pubs.acs.org
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Science Magazine
@ScienceMagazine
15 Feb 2024
In honor of #WorldAnthropologyDay, learn more about how the spread of agriculture didn’t just change our diets—it altered our jaws as well, making it easy to pronounce "f"s and "v"s and opening a whole new world of words. scim.ag/5SZ @NewsfromScience

Ancient switch to soft food gave us an overbite—and the ability to pronounce ‘f’s and ‘v’s

How farming reshaped our smiles and our speech

science.org
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Ling Ding@bcdingling
10 Feb 2024
Outdoor Jogging:) Dragon means power, strength, vigour, and charm. I wish a peaceful world and healthy planet.
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nature
@Nature
19 Jan 2024
How an exercise habit paves the way for injured muscles to heal go.nature.com/3tZ0zlL

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