๐จSuper proud of a new publication from our lab spearheaded by @MarieDeBorre, together with @UZLeuven, @ZOLziekenhuis and @azsintjan. We provide proof-of-concept that cell-free DNA (cfDNA) methylome analysis allows for early preeclampsia (PE) prediction. rdcu.be/dla4e
Volg morgen en overmorgen van 10 u. tot 16 u. alle ๐ฒ๐ฌ๐ฌ ๐ฆ๐๐๐ข๐ก๐๐๐ก๐๐๐ญ๐๐ก๐๐๐ก tijdens @KU_Leuven Inside live op ROBtv. #robnieuws#robtv
LISCO is looking for an experienced Business Developer in Single-Cell and Spatial Multi-Omics for Biomedicine to take our cutting-edge lab services and research capabilities to the next level.๐ Apply here: kuleuven.be/personeel/jobsitโฆ or feel free to share with your network!
Are you active in #sequencing and want to show your research to leading researchers? Submit an abstract for #RNGS25: vibbio.tech/3ZY5IYl
Present on stage with a poster pitch or during the poster sessions.
The abstract deadline is 15 January 2025.
#ngs#genomics#multiomics
Many thanks @NatMetabolism for publishing and highlighting our research, all members of our lab, the excellent collaboration with @bernthie and especially first author @SteveStegen
We are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details below ๐.
๐ข Calling all future cancer researchers! Adaptmet is offering 16 MSCA PhD positions in cutting-edge metastasis research. Join us to shape the future of cancer science with exciting projects among Europeโs best teams from top host institutions! Apply now ๐adaptmet.eu/recruitment/
Lannoo et al. examined whether rare autosomal trisomies revealed by noninvasive prenatal screening reflect fetal trisomy or confined placental mosaicism and whether they are associated with โฌ๏ธ likelihood of adverse perinatal outcomes. Full correspondence: nej.md/3RVX34b
ALT Bar chart of the outcome of pregnancy according to (mosaic) fetal trisomy or confined placental mosaicism and according to chromosome.
Prof. Joris Vermeesch shares updates on Implementing Genome Sequencing to Solve Rare Disease Cases in Belgium: Learnings from the Nationwide RCT BeSolveRD #ESHG2024
Happy to share our deep dive into Methods and applications for single-cell and spatial multi-omics @NatureRevGenet, with the magnificent Katy Vandereyken, Alejandro Sifrim & Thierry Voet from the @KU_Leuven Institute for Single Cell Omics @CHG_CMErdcu.be/c6JjL
paper alert ๐จFiguring out the cellular composition of tissues is essential for understanding diseases. DNA methylation analysis is particularly suited for this task, as deconvolution algorithms can untangle mixture signals from bulk samples into their individual components.
For sequencing-based DNA methylomes, we also assessed how sequencing depth and uniformity affect performance. This resulted in a nuanced set of recommendations for optimal deconvolution, depending on the underlying research question and goal.
Thanks to @ridderkobe for expertise, persistence and diligence, to other members of the lab and reviewers for their insights, and @FWOVlaanderen and @Stkstichting for support! Happy deconvolving to you all! rdcu.be/dH55V