𝗧𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝗣𝗮𝘁𝗰𝗵𝗹𝗶𝗻𝗲𝗿ᵐ 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗚𝗿𝗮𝗻𝘁 𝗶𝘀 𝗵𝗲𝗿𝗲! What if patch clamp could be fast and simple, while keeping you fully in control? Many ion channel experiments are delayed by limited access to patch clamp equipment, resources, or expertise. Patchlinerᵐ offers a simpler way of doing patch clamp, helping researchers accelerate experiments and record multiple cells simultaneously. This grant is designed to help researchers explore ion channel biology, biophysics, target validation, and assay development. The selected recipient will receive: ✔️ Patchlinerᵐ in their lab for 6 months ✔️ Full training ✔️ Consumables for the research project ✔️ Expert assay and application support 🗓️ 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗽𝗲𝗻: July 2026 Want to be the first to receive updates about the grant? 𝗥𝗲𝗴𝗶𝘀𝘁𝗲𝗿 𝘆𝗼𝘂𝗿 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁 𝘁𝗼𝗱𝗮𝘆: ow.ly/wVPk50YYWoy #PatchClamp #Electrophysiology #IonChannels #APC

Glenn-Fontan procedure is essential to treat Single-ventricle congenital heart disease However, Glenn surgery▶️loss of pulmonary arterial flow pulsatility & pulmonary vascular malformation How?🤔 Here, in this fresh-on-the-shelf @JCI_insight paper Dr. Ondine Cleaver lab @cleaverlab😎 👉Profiles biophysical alterations of right pulmonary artery flow in a rat model of Glenn surgery Simultaneous drop of 1⃣Velocity 2⃣Pressure 3⃣Circumferential stretch 👉Dissects the transcriptomes of pulmonary arterial endothelial cells with Pulsatile vs Non-pulsatile 1⃣Flow/Shear 2⃣Pressure 3⃣Stretch Several intriguing findings 👉Puls. Pressure & Stretch ⏬Proteasome ⏫mTOR 👉Puls. Stretch ⏫Notch HedgeHog 👉Puls. Flow & Pressure ⏫TGFβ 👉No impact on arteriovenous differentiation 👉Mechanosensitive, Dimension-specific #Angiogcrine!!🤩 A critical in vivo relevance Puls. Stretch-induced endothelial PDGFB maintains Pulmonary Arterial (not Venous) Smooth Muscle Cell Mass🤠 Does ECMO non-pulsatile flow cause similar mural-weakening issues? insight.jci.org/articles/vie…

🚨 SAVE-THE-DATE 🚨 SEEON ANGIOSCIENCE! Fantastic, long-running meeting on Development & Maintenance of the Vasculature. 🗓️ Sept 2026 🌍 Bavaria, Germany Registration open! Join us! vwfb.de/start/registration-m…