It was a real honor to deliver the Opening Keynote at the Royal Society’s AI & Law Conference last week in London ! Thanks to all of the organizers and fellow speakers for this important dialogue regarding the future of our field. Link to Event Here: royalsociety.org/science.../…

All of these were reported over the past month: • A new pancreatic cancer drug, daraxonrasib, that roughly doubles survival in late-stage disease • A precision lung cancer drug, lorlatinib, that kept 55 percent of patients progression-free after 7 years, versus 3 percent on the old drug • A prostate cancer drug, talazoparib, that halves the risk of progression • An endometrial cancer drug, dostarlimab, where 58 percent of patients hadn't progressed after 4 years, versus 16 percent on chemo alone • An early-detection blood test, the NHS Galleri test, that quadrupled cancer detection but missed its main goal • An mRNA cancer vaccine that halved the risk of melanoma recurrence when added to Keytruda • The most effective weight loss drug so far, retatrutide, which cut body weight by about 28 percent • The first in vivo gene editing therapy, which cut hereditary angioedema attacks by 87 percent from a single injection • A one-time gene edit, VERVE-102, that lowered LDL cholesterol by 62 percent • A feat of pharmaceutical synthesis that raised enlicitide's manufacturing yield 14-fold using engineered enzymes • A functional cure for hepatitis B, bepirovirsen, that cleared the virus in about 20 percent of patients • The discovery that human cells can swap chromosome-sized DNA through nanotubes • An ancestor of CRISPR, VIPR, found in bacteriophages, that silences genes without cutting DNA • A preventive Covid-19 pill, ensitrelvir, that cut symptom risk by 67 percent after exposure • The first PROTAC drug, vepdegestrant, which destroys a disease-causing protein rather than blocking it Every month, Niko and I write a round up digging into the latest news in biotech and medicine, and this month's was astonishing. We share some thoughts on what's responsible for this progress and what it means for science in the future.

NEW: Inside the 24-hrs before WH slapped export controls on Anthropic - Last Thursday, Amazon CEO Andy Jassy raised concerns about Fable jailbreak to Trump admin - Friday AM, Sean Cairncross, Bessent, Susie etc. held WH call to discuss - Then White House started reaching out to Anthropic to speak with Dario Amodei, who was at a wellness retreat. - When Amodei was finally available past 1pm, he had three tense phone calls with a combo of ppl including Cairncross, Bessent, Lutnick, Kessler, Will Scharf, Richard Walters, and Walker Barrett. -Amodei tried to clear up what he assumed was a misunderstanding. He defended the guardrails and distinguished between universal and non-universal jailbreak - Cairncross and Bessent were unmoved and asked Amodei to take down Fable and work with the admin to fix the vulnerabilities. (A WH official said Amazon’s findings were run past the NSA and they felt they had “proof.”) - Amodei asked for more time and info, but he made no commitments to pull the model - Bessent told Amodei directly at one point that he was making a “bad decision” - By Friday evening, the Trump admin imposed its export controls. - “Export controls were a last resort after begging them for hours to work with us,” senior WH official said. W/ @cheyennehaslett politico.com/news/2026/06/13…

The letter reached Dario Amodei Friday night, around 9:47, and by the time I left the building the sequence was already closed. I am the Deputy who ran the interagency process on Claude Mythos 5 / Fable 5, and it took an afternoon. Andy Jassy had told Scott Bessent that Amazon's own researchers used Claude Fable 5 to pull cyberattack-useful material out of the model. Bessent called me. I called Commerce. By Saturday morning, Fable 5 and Mythos 5 were dark for every user on earth. People ask why I trusted Amazon. Amazon put roughly eight billion dollars into Anthropic, a stake the cap table now carries near seventy-four billion, and a man does not call a Cabinet secretary's cell on a Friday to put a number like that at risk unless he has already decided how the call should end. Jassy decided. Seventy-four billion at risk. That was the number I weighted. Then I picked the instrument. A safety review takes weeks, because you have to convene the reviewers, argue the capability, survive the dissents, and stand behind a written finding that someone can later prove wrong. An export-control order takes a signature. I treated Fable 5 the way we treat an advanced chip, put the weights on the same control list as the silicon they run on, and because showing those weights to a foreign national inside our own building counts as an export, I barred foreign-national access worldwide, including Anthropic's own foreign-national staff, overnight. That same week we cleared the advanced chips themselves for sale to China. The silicon shipped. The model a Chinese national could touch on US soil went dark. Export control does not require you to be right by Monday. That is why I used it. Then the collateral, and I will be precise, because it is what closed the file for me. The ban cut off AWS, Amazon's own cloud, the one Anthropic had pledged about a $100 billion dollars to run on, which means the partner who reported the threat severed his own data centers to land the finding. He took the loss himself. That settled it for me. One of Anthropic's own engineers, a green-card holder, lost access Saturday morning to the model she had spent two years building. Her code is still inside it. She can no longer open the thing she made. I noted that the rule was working as written. I never ordered the models pulled. The finding was briefed to us out loud. Nothing on the record, no exhibit, no written determination, just Sacks describing the source as a highly credible trusted partner, and credible was enough. My ask to Dario was three words. Fix it or pull it. I put it on a recorded line so the choice would be his on the record, and when he would not accept my read he pulled both Fable 5 and Mythos 5 himself, for every user on earth. I signed nothing that made him. Anthropic came back with a rebuttal. The jailbreak was narrow. OpenAI had shipped the same capability in GPT-5.5 that same month, and the letter named no specific national-security detail. All true. GPT-5.5 had no investor with a reason to call, so GPT-5.5 got no letter. Before this weekend, no frontier model had ever been pulled from the public by this government. Now one has, and the procedure has been tested in production. The list had no names. Now it has mine.

I’ve had a number of conversations with folks inside and outside government about the current situation with Anthropic, and here is what I believe to be true: — As we know, Anthropic publicly released its Mythos class models earlier this week under the commercial name Fable. — Fable is Mythos with guardrails. But if those guardrails fail, then you’ve exposed Mythos and its advanced cyber capabilities to people who shouldn’t have them. (Keep in mind that Anthropic itself widely promoted the idea that Mythos was a cyberweapon and needed to be regulated as such. They asked for government regulation of Mythos and championed the guardrails on Fable. If there is a vulnerability — big or small — it is Anthropic’s responsibility to patch.) — A highly credible trusted partner of both Anthropic and the USG who was testing Fable came forward with a jailbreak of those guardrails. The Admin asked Dario to fix the jailbreak or de-deploy the model. Dario refused. — In their blog post, Anthropic defended its decision by saying the jailbreak isn’t serious. That is not what the trusted partner and the USG believe; nor is that kind of minimizing language consistent with Anthropic’s brand as the AI safety company. It’s difficult to fathom how they could claim a jailbreak allowing operability of a cyber weapon could be defined as not “serious.” — In the past, Anthropic has always said that safety must be top priority and taken super seriously. In this case, Anthropic prioritized the continued offering of the consumer model over safety. — In reaction, the Admin issued the export control. The Admin did this reluctantly. It’s been very surprised that Anthropic hasn’t wanted to cooperate with a reasonable safety request (ie fixing the jailbreak issue). Anthropic’s reaction is very much at odds with their branding and ethos as a safe AI research community. — The Admin’s hope now is that Anthropic remediates the safety issue, the export control is lifted, and Fable goes back into general release. The Admin wants all of this to happen as soon as possible. It is frankly bewildered that Anthropic hasn’t wanted to comply with safety requests that it previously said were its highest priority. — Those trying to misdirect and tie this action to the prior DoW/Anthropic issues are wrong. The Admin values Anthropic’s technical capabilities and feels that this issue, while serious, should be easily resolved. The ball is in Anthropic’s court.

This is a very interesting paper - have not seen a whole lot of discussion on it so far but I just gave a talk on it and other related ideas ... pnas.org/doi/10.1073/pnas.25…

Our report "From AGI to ASI" is out!

The US government, citing national security authorities, has issued an export control directive to suspend all access to Fable 5 and Mythos 5 by any foreign national, whether inside or outside the United States, including foreign national Anthropic employees. The net effect of this order is that we must abruptly disable Fable 5 and Mythos 5 for all our customers to ensure compliance. Access to all other Claude models is not affected. We apologize for this disruption to our customers. We believe this is a misunderstanding and are working to restore access as soon as possible. Read our full statement: anthropic.com/news/fable-myt…

Opening Statement. 🇺🇸

Gio Reyna's first-ever FIFA World Cup goal was a trivela to seal it for the @USMNT 🤯 It's the first four-goal outing for the US men's squad in a FIFA World Cup

Crack the Sky. 851pm on Thursday in Chicago during a massive storm.

All in the details.

Lighting up the night sky in Mexico City for the #FIFAWorldCup ✨ #NovaSkyStories

Seinfeld episode 2026: Jerry gets tickets courtside and brings George, who decides, with the Knicks down 20 with 10 minutes left, he will leave the game early to beat the rush out of MSG. As the Knicks mount a comeback he tries to get back into the Garden. He waves his ticket, name drops James Dolan, but nothing works and he ends up getting arrested. Meantime, Kramer sneaks into the Garden and helps Mike Brown draw up the game winning play.

This is it. OpenAI is now considering drastic price cuts to win users from Anthropic, who will likely cut right back. Two companies losing billions, about to compete each other's margins to zero. Buffett's worst kind of business: one that grows rapidly, devours capital, and earns nothing. He meant airlines. The most important industry of its age, where the customer wins and the shareholder bleeds. Revolutionary technology and a good investment have never been the same thing. The internet was real too. Most of the companies building it still went to zero.

This is just a glimpse of what AI can do for education. A whole new world.

I made a personal black hole that makes you take breaks 🕳️ A shader for Ghostty that spawns a small black hole in your terminal - it drifts around, gravitationally lensing your text. The longer you work without stopping, the bigger it gets, until it's basically demanding you go touch grass Take a break and it quietly shrinks away

OpenAI’s Sora simulates the physics of our visual world. But can we build the physics engine for human society? We can. 🌍 Using Polymarket and Kalshi as the ultimate testbed, we show that LLMs can act as simulation engines for macro social dynamics. Introducing our ICML 2026 paper: "Building Social World Models with Large Language Models". 👇 📄 Paper: arxiv.org/abs/2606.11482 💻 Code: github.com/ulab-uiuc/social-… 🤗 Data: huggingface.co/datasets/ulab…

Incredible experience just being a fan at Game 4 at MSG! This is why we love sports-Here was my angle for the game winner… @nyknicks down 29 and just kept choppin wood to give themselves a chance at the end-and won it with poise and determination. Appreciate Mark Shapiro for the invite to witness it in person. Nothin better!

A play New York won’t forget: