"RNA-Seq: the teenage years" our review in @NatureRevGenet is now online. Thanks to my co-authors, to everyone who's work we cited and to all of you using RNA-Seq. Enjoy! nature.com/articles/s41576-0…

I just sequenced a human genome to 30× coverage entirely at home. As far as I know, this is the first time this has been done. I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table kitchenette. Six weeks ago, I had never done wet lab biology before. I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home. Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible. I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert. For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand? To make this work, I had to navigate multiple disciplines: - writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling - learning executing 5 hour long molecular biology protocols - building a hardware device to quantify DNA concentration Apologies for the hyperbole, but I feel super lucky to be living in 2026. A few weeks ago I decided to sequence a human genome to 30x at home. Then I actually did it. And I did it really quickly.

Long time since I posted but here's a link to my new 'haystack': coregenomics.substack.com/su…

Absolutely rammed on the @greateranglia 16:28 CBG to NWI and the guard has done nothing to move bags or people from STN even though they knew this was a 3 carriage train. They need to do their job and manage the bike area rather than hide in their office.

The bogeys at the back of carriage 912409 are rocking the @greateranglia 14:26 CBG to NWI like mad. I could probably make the perfect Bond martini, shaken not stirred! Seriously though yesterday’s train was worse. Is it the rolling stock or the track? And is it a safety issue?!

Hi @sainsburys my packet of bacon appears to have a little bit of blue hair net or beard guard in it, or it could be from a scouring pad. I guess it’s not supposed to be there so who do I need to tell?

Morning @greateranglia there’s no salt off the bridge at Wymondham and it was dangerously icy carrying my bike down this morning. Will the new tunnel enable step free access to platform 2 in the New Year?

Well that’s not a very nice review by stuart heritage in the @guardian on a Christmas institution - the @JohnLewisRetail ad And slightly ironic that it ended with this NB: article was amended to remove a suggestion that print journalism is “obsolete”! theguardian.com/tv-and-radio…

Jacob Thaysen @illumina CEO “China’s back on the menu boys!” illumina.com/company/news-ce…

Innovation opportunities: £50M into cfDNA @ourfuturehealth by Lord Patrick Vallance KCB and @SciTechgovuk would bring >$1B in investment of R&D in the UK by early detection research companies along with the AI investments too. But we don’t seem to have the cash!!!

Nooo!

Check out Joseph Tawadros's song about how @TRobinsonNewEra sold out in Tel Aviv! #TikTok vm.tiktok.com/ZNdceo2Uu/

MiSeq i100 1000 cycle (2x500) kits coming soon #AGBT25

cfDNA fragmentomics review reviewed by Enseqlopedia and written by @Addytsui. Peiyong Jiang and Dennis Lo. There's lots here on @DELFIDiagnostic's worth reading (maybe see you guys at ESMO?). enseqlopedia.com/2025/10/cfd…

How big would ABI377 plates need to be to deliver @illumina NovaSeq X Plus output? I am now officially a ChatGPT maGPTician. enseqlopedia.com/2025/10/how…

Billy Bragg on banning Israel from Eurovision: "Russia was banned.. after the invasion of Ukraine & I think if we have one rule for the Ukrainians and another rule for the Palestinians, it starts to look like we only care about white skinned people and not brown skinned people"

A year before the Little Rock Nine, Bobby Cain helped integrate Southern schools edition.pagesuite.com/popove…

So ⁦@firstdirect⁩ send me an email that stay “Scammers don’t want you to read this”…and they expect me to open it to read it?! Is this a scam.