We have written a free book (monograph) on why people believe crazy things, including #Brexit . You can download it at osf.io/pnxcs #openaccess #FBPE - please RT #beliefbook @beliefbook

I'm giving an online webinar/talk on microclots in #LongCOVID and #MECFS on Wednesday this week June 17 at 2pm UK time. Registration required but free register.gotowebinar.com/reg… #TeamClots

Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications 🚨INTERESTING New Latvian/Swedish multi-omics study shows immunothrombosis never fully switched off in longC0VID patients: 3 months after COVID hospitalization, your blood is still biologically “clot-ready.” ➡️What makes this study so important: 1. It reinforces that immunothrombosis (the interplay of complement, NETs, and platelets) is a central driver in severe acute COVID-19 and can persist in longC0VID, 2. It confirms persistent endothelial Dysfunction/Endotheliopathy in longC0VID patients, consistent with earlier studies on vascular damage and microclots, 3. It aligns with prior evidence of mitochondrial dysfunction during the acute phase, followed by partial repair mechanisms, 4. The persistent complement activation they observed fits with other recent multi-omics studies showing ongoing complement dysregulation in longC0VID. ➡️Study: 1. Prospective longitudinal multi-omics study of 81 hospitalized COVID-19 patients tracked whole-blood transcriptomics, urine metabolomics (46 analytes), and 13 kidney-injury biomarkers at acute admission, ~1 month, and ~3 months post-hospitalization, 2. Patients stratified by EHR into recovered (n=35) versus long COVID (n=46) groups based on a PASC diagnoses within 12 months, 3. None of the 81 hospitalized patients were vaccinated, 4. Acute phase dominated by interconnected immunothrombosis: strong upregulation of complement (C1QA/B/C), NETosis (PADI4, MPO), and platelet-activation genes (ITGA2B, ITGB3), plus mitochondrial dysfunction (HIF1A/EPAS1 up, OXPHOS down, Warburg-like glycolysis) and elevated renal injury markers (KIM-1 etc.), 5. Most immune, mitochondrial, and metabolomic changes largely normalized by 1–3 months, with rebound in mitophagy/heme genes (PINK1, OPA1, FECH) indicating repair, 6. At 3 months, longC0VID patients showed a distinct transcriptional signature of persistent endothelial activation (↑VWF, PROS1, ITGA2B/ITGB3), complement dysregulation (CFH), and low-grade vascular inflammation/platelet reactivity (CXCL5, ALOX12) that was absent in recovered individuals, 7. No significant late differences in urine metabolomics or kidney biomarkers between groups. ➡️They conclude with their Highlight-points: • Severe COVID-19 induces immunothrombosis-associated molecular programs, • Acute COVID-19 is associated with mitochondrial metabolic dysregulation, • Urine profiling indicates gradual renal recovery after hospitalization, • LongC0VID patients retain endothelial-associated activation signatures. ‼️So, even after apparent clinical recovery, immunothrombosis leaves a persistent molecular scar of endothelial activation and prothrombotic signalling in longC0VID patients at three months, revealing that the acute vascular battlefield never fully quiets in those who remain symptomatic. →Three months post Covid-19, longC0VID patient’s blood is still biologically primed to clot! #AvoidSars2 #AvoidReinfections cell.com/iscience/fulltext/S…

You'd have to say Morocco's footie team look terrific... #wc2026

Template: I'm joining the call for up-to-date scientific representation & meaningful patient engagement in Long Covid and ME. I'm proud to support the Open Letter to RCPsych, backed by 58 orgs & 1200 signatories. #HearOurVoices #RCPsychIC 📩 tinyurl.com/46enh82n (add image 👇️)

🗞️ Stop Press: MON 15th - We are coordinating an outreach campaign to the Royal College of Psychiatrists Congress to ensure the community's concerns about the framing of Long Covid are heard. This is a powerful opportunity for them to #HearOurVoices Template to C P below 👇️

And IMHO a lot of people will lose a lot of money when they realise how much of it is vapourware...

🔗 Paper COVID-19 as a Modifier of Genetically Determined Coagulation Phenotype: Implications for Precision Risk Stratification After Infection FYI/@resiapretorius link.springer.com/article/10…

Which public health crisis gets the least media coverage relative to its actual scale? Air pollution: about 30000 UK deaths a year. Long COVID: around 2 million people affected in England and Scotland. Antimicrobial resistance: estimated to contribute to 35000 UK deaths a year, likely to grow. Mental health: when services fail, the consequences don't stay in clinics. They show up in families, homelessness, A&E, schools, policing, safeguarding failures... and sometimes riotous national crisis.

Not just water. UK 7th most expensive country for electricity too... visualcapitalist.com/electri… #RipOffBritain

This needs posting everywhere

Water is too precious and sewage too dangerous to be in private hands.

The call for public ownership of the water industry is growing louder everyday. Why are govt refusing a referendum, why are govt refusing to allow the public to decide? megaproject.com/news/water/d…

Thames Water wants to set its own rules. The Board of Ofwat is split over whether to let them. Tip the scales in favour of people and planet: email the Board now, and urge them to reject Thames Water's creditors @We_OwnIt weownit.org.uk/stop-thames-w…

Reality Defies Trump-Friendly Predictions open.substack.com/pub/contra…

I think he means you and yours @RupertLowe10 @Nigel_Farage - maybe take heed this time.

Worth a reminder en.wikipedia.org/wiki/McLibe…

Absolute disgrace by Govt changing rules in this way: theguardian.com/money/2026/j…

Brilliant interviews Matthew O’Toole and Alison Morris in Belfast ,.. clear message to the far right rabble rousers Musk and Yaxley-Lennon to stick their fascism where the sun don’t shine! Words to that effect. They care nothing for N Ireland and know less.