77 Photos and videos
Daniel Ives retweeted
1/ How long do you want to live?
For most of human history, aging was inevitable.
It's now solvable.
Apply for LBF8 cohort program: longbiofellowship dot org
/THREADđ§”
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Daniel Ives retweeted
Apr 21
âYouâre born, you grow up, you have a career, and then you get older and then you die. And that's just like the acceptable plan. Even if the plan is horrible⊠as long as we're going to plan, everybody goes along with it.â
@realNathanCheng is one of the most prolific activists in the longevity field. He argues that aging, decline and death are not really a great plan, even if it's the way things work today. He has dedicated his life and career to finding us a new plan.
Follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech!
0:00 Intro
2:35 Why did Nathan dedicate his life to defeating aging & death? (And the absurdity of asking that question)
8:59 Why has Daniel been on the fence, despite being longevity-pilled
14:09 The agency and bravery of founders to tackle the hardest problems (like aging)
18:46 Many ways to contribute to longevity besides entrepreneurship
19:41 Is longevity underinvested into?
24:48 What does it mean to treat aging itself as the issue (vs other diseases)
32:23 Do we need more scientific arguments, or philosophical arguments?
39:50 Nathanâs experience longevity-pilling influential people
47:03 Billionaire paradox
53:18 The challenge in going from viewing aging as inevitable to malleable
57:29 What needs to change about our culture to save us from aging & death
1:16:55 Should we be intolerant of pro-death & pro-aging views?
1:22:59 Join us at Vitalist Bay!
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Daniel Ives retweeted
Feb 21
Single-cell epigenome atlas identifies kidney epithelial cells as a driver of epigenetic aging. Lake et al. (2026) build a cross-species atlas showing that aging is driven by collapse of 3D chromatin structure in tubular epithelia. Beautiful multi-omic work.
biorxiv.org/content/10.64898âŠ
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Crows discovered antibiotics millions of years before humans.
When a crow gets sick, it does something that looks insane â it finds an ant colony and deliberately pisses them off.
The ants attack. They spray formic acid everywhere in defense.
The crow? Doesn't run. It spreads its wings and just... takes it. Lets the ants crawl all over its body.
Here's the genius part: Formic acid is a natural antibacterial and antifungal compound. It kills the parasites and microbes that destroy feathers. The crow is basically giving itself a chemical bath.
Scientists call this "anting." Over 200 bird species do it. First documented in 1831, but birds have been doing it for millions of years.
It gets weirder.
When ants aren't available, some birds grab LIT CIGARETTE BUTTS and rub themselves with the smoke instead. They found a substitute for their medicine.
We spent centuries "discovering" antibiotics. Crows were running their own pharmacy this whole time.
Here's what strikes me: evolution is the original drug discovery engine. Billions of years. Trillions of experiments. No hypothesis â just relentless trial and error until something works.
Now we're building AI systems that do the same thing for antibody design â searching vast molecular spaces, predicting protein structures, optimizing binding affinity. What took nature millions of years, AI can explore in days.
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Daniel Ives retweeted
Feb 11
Last week my shortest podcast interview dropped (Decoding Longevity). This week here's my longest just out (Free Radicals). Great wide-ranging conversation covering the aging biotech sector & companies getting to approvals but also how to think about stuff available now.
Feb 10
For our 10th episode of the Free Radicals podcast, @EricDai_BioE and I are excited to host @KarlPfleger
After a decade as one of the first AI researchers at Google from 2002 to 2011, Karl dedicated himself to the cause of rejuvenation biotechnology.
He is a philanthropist, community builder, and prolific angel investor with over 35 investments into rejuvenation biotech startups. His website, agingbiotech.info, provides valuable information to the entire field, and his talks and X posts are highly insightful and influential within longevity.
Karl has deeply researched and nuanced takes, and those really show in this conversation. We cover why epigenetic reprogramming wonât solve aging, Karlâs investment strategy, what distinguishes true rejuvenation technology, why better diagnostic technologies could be the key to personalized aging interventions, and much more.
Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio!
0:00 Intro
1:56 Peter Attia and defining longevity
8:37 What is aging?
12:41 Wear and tear vs programmed obsolescence
16:12 Which molecular mechanism of aging do we have the most control over?
19:29 Does partial reprogramming solve the whole aging problem?
25:23 How to identify truly rejuvenating therapies
32:35 The role of AI and good screening technologies
37:03 Do we understand the mechanisms of aging well enough to intervene?
38:39 Will there be a longevity tipping point?
44:51 Karl's investment strategy for aging biotech
52:21 Senolytics
1:01:33 Misfolded protein clearance & mitochondrial transplantation
1:08:21 Sauna & parabiosis (not combined)
1:15:54 Stem cell therapies
1:22:02 Karl's research process & formal techniques for evaluating arguments
1:28:55 The successes of the geroscience paradigm
1:34:13 Diagnostic bottlenecks
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Daniel Ives retweeted
Feb 3
This week, we are excited to welcome @dives86 onto the Free Radicals podcast!
Dr. Daniel Ives is the founder of @ShiftBioscience. Shift has built a novel single-cell aging clock that has enabled them to run high-throughput screens to discover genes that regulate aging, with the goal of identifying a therapy to systemically reverse aging. Theyâve raised $16M from investors like Business Growth Fund, @FPrimeCapital, and @Kindred_VC to pursue this mission.
In this episode, we discuss Shiftâs formation and their approach, and dive deep into two promising targets theyâve discovered, as well as the coming cultural shift when anti-aging drugs become mundane reality.
Be sure to follow @FreeRadicalsBio and @EricDai_BioE for weekly episodes about longevity biotech!
0:00 Intro
1:37 Deciding to work on aging
5:52 Origins of Shift Bioscience
9:54 Role of mitochondria in aging
13:03 Aging clocks & the meeting that led to XPRIZE Healthspan
18:11 Cracking the single cell aging clock
21:45 The accuracy and role of aging clocks
27:28 A single gene that reverses cellular age
36:59 Engineering small molecules for age reversal
43:07 How virtual cells accelerate scientific progress
49:55 From virtual cell to virtual human?
56:54 Asking the right questions
01:07:57 Backup plans
01:10:43 Lightning round
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Daniel Ives retweeted
Jan 29
𧔠Elon: âLongevity is an extremely solvable problemâ
At Vitalist Bay (May 14 - May 17), weâre solving it!
1K pioneers, 100 speakers, 50 workshops, 40 activities, 5 critical health tests
Join us to spark dozens of SpaceXs for longevity!
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Daniel Ives retweeted
Here's the story. Sinclair showed in 2020 that mice whose eye nerves were "reprogrammed" regained vision after an eye crush injury.
Now, basicially the same technology is going to be used in human
technologyreview.com/2026/01âŠ
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Daniel Ives retweeted
22 Dec 2025
This yearâs biggest breakthroughs in longevity are now up !!
youtu.be/X-Hzyzo1Jpk
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Daniel Ives retweeted
27 Nov 2025
Everything you want is on the other side of difficulty, uncertainty and delay.
Hard problems - that you don't know how to solve - on a timeline you aren't sure you're going to solve them in - all while being unsure if all this will have been for nothing.
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Daniel Ives retweeted
21 Nov 2025
What if our descendants look back at our acceptance of aging the way we look back at medieval medicine?
We interviewed them.
Dystopian futures are easy to imagine. Optimistic futures take vision and courage to build.
VOICES FROM 2099:
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Daniel Ives retweeted
18 Nov 2025
Today I am launching the Free Radicals podcast with @EricDai_BioE . Every Tuesday, weâll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan.
Weâre thrilled to host @celinehalioua, Founder CEO @loyalfordogs, for our inaugural episode. Celine is building the worldâs first lifespan extension drugs for dogs.
Follow me, @EricDai_BioE and @FreeRadicalsBio for new episodes every Tuesday.
00:00:00 - Intro
00:01:51 - Celineâs background
00:05:00 - Dropping out of academia
00:07:50 - Finding ways to increase free will
00:09:36 - How to align financial incentives with longevity
00:14:52 - Longevity drugs should be boring
00:21:24 - Celineâs leadership style
00:24:08 - Advice on fundraising and constructing feedback loops
00:26:52 - Loyalâs fundraising history
00:27:57 - Building for Zero Billion Dollar Markets
00:29:11 - How to succeed in biotech
00:30:21 - How to find blockbuster opportunities
00:33:25 - How to create a gold rush in longevity
00:35:25 - The problem with the aging field
00:39:32 - How to identify signal from noise
00:41:54 - AI applications to biology
00:45:15 - Importance of naiveté
00:47:24 - FREE RADICALS
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8 Nov 2025
I'm excited to be speaking at @RNID's Hearing Therapeutics Summit 2025, which is helping to speed the development of therapeutics for hearing loss and tinnitus. With a strengthening link between age related hearing loss and the underlying aging process, hearing loss has become a new test bed for cellular rejuvenation gene therapy. Find out more about the programme rnid.org.uk/hearing-researchâŠ
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Daniel Ives retweeted
4 Sep 2025
âHealthy agingâ is an oxymoron! That notion must end! If your biology were perfectly healthy, you would not age. This slogan has severely narrowed the scope of aging research & longevity priorities & has been harmful to genuine efforts for targeting root causes to reverse aging.
2 Sep 2025
đŹ Exciting news! Buck donor James B. Johnson, MD is producer of new film Forever Young, features groundbreaking work of Buck scientists and others advancing future of healthy aging. Weâre thrilled to share that film has been officially selected by @MVFilmFest! @TheAgingDoc
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Daniel Ives retweeted
21 Aug 2025
Criticism is a fixed cost of taking action. People will criticize you if you anything note worthy. Theyâll also criticize you for doing nothing. So you might as well just do what you want.
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Daniel Ives retweeted
23 Jul 2025
Who is looking for $500k in Bio?? Apply now for the @BoostVC Residency!
24 Jun 2025
I believe that the startups that will cure cancer, enlongate life 50 years and give humans super powers are starting today!
So we are launching a Bio Residency @BoostVC to bring the best builders in Bio together!
APPLY NOW!!!!
adamdraper.vc/p/the-boost-vcâŠ
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Daniel Ives retweeted
Chatting with JellyfishDAO next week!
16 Jul 2025
Set your calendars for an exciting X space event between @LBF_org Co-Executive Director @realNathanCheng and @JellyfishDAO host @LongevityLawson where they'll discuss LBF, longevity, and more.
x.com/i/spaces/1YpKkBgarqjxj
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NEW: No technology currently exists to repair damaged brain tissue and fully restore lost function. FRONT aims to enable millions with what is considered permanent brain damage to regain lost functions, including motor control, vision, and speech. arpa-h.gov/news-and-events/aâŠ
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Daniel Ives retweeted
9 Jul 2025
What is the state of research on the emerging grand challenge of virtual cell modeling? 1/n
open.substack.com/pub/behindâŠ
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Daniel Ives retweeted
9 Jul 2025
âThis feels like alien technologyâŠâ đœ
In Ep. 8 of Decoding Longevity, @lucascamillomd explains SB000 â a gene that could safely reverse aging. No magic. Just science.
đ§ Listen now
open.spotify.com/episode/1c2âŠ
#Longevity #SB000 #AgingScience #AlienTechButReal #DecodingLongevity
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