CONGRESS |
#EHA2026 | PRESENTATION
Johannes Schetelig presents findings from a randomized non-inferiority trial evaluating PTCy-100 vs ATLG-30 as
#GvHD prophylaxis in allo-HSCT recipients from unrelated donors (N = 640).
In the ITT population, the 2-year OS was 68% with PTCy-100 vs 75% with ATLG-30 (HR, 1.341; test for non-inferiority, p = 0.85; test for superiority, p = 0.051). The 2-year GRFS was 48% with PTCy-100 vs 40% with ATLG-30 (HR, 0.85; p = 0.16). The 2-year cumulative incidences of relapse were 26% and 31% (HR, 0.86), respectively. The 2-year NRM was 13% with PTCy-100 vs 7% with ATLG-30 (HR, 1.86; p = 0.02). Overall, confirmatory testing demonstrated that non-inferior survival with a 5% margin for PTCy-100 compared with ATLG-30 could not be shown.
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