Building memories is energetically expensive. New research reveals that microglia help meet this demand by orchestrating a neuroimmune metabolic circuit that boosts glucose transport to active brain regions, fueling neuronal protein synthesis required for learning. During motor learning, microglia release CYR61, linking metabolic support to synaptic plasticity and memory formation. #Neuroscience #Microglia #BrainMetabolism cell.com/cell-metabolism/ful…

Firstever image of a border associated macrophage in human brain. This has been shown residing in the newly reported meningeal layer biorxiv.org/content/10.1101/…

1/12 Excited to share our new Nature paper: “A thalamus–brainstem attractor network drives history-biased decisions” How does the brain use recent experience to guide the next decision? #Neuroscience #Zebrafish #DecisionMaking nature.com/articles/s41586-0…

Visualization of Intermediate Leptomeningeal Layer in Hierarchical Phase-Contrast Tomography (HiP-CT) of the Cadaveric Adult Human Brain doi.org/10.6084/m9.figshare.…

Visualization of Intermediate Leptomeningeal Layer in Hierarchical Phase-Contrast Tomography (HiP-CT) of the Cadaveric Adult Human Brain share.google/xhMEGmd4KFOugku…

Visualization of the Intermediate Leptomeningeal Layer, a new meningeal layer in Human brain using HiP-CT doi.org/10.6084/m9.figshare.…

Source: News-Medical share.google/lolvL5hA08PmGPv…

DG @ICMRDELHI Dr Bahl describes the far reaching changes that will strengthen the health research ecosystem of the country, to face present & future challenges. Research, that generates contextually relevant evidence, is necessary for sound policy formulation. @MoHFW_INDIA

A mystery that is brain: nature.com/articles/d41586-0…

BREAKING: Scientists have engineered a virus that invades and destroys glioblastoma one of the deadliest brain cancers. It also turns the immune system into a relentless tumor-killing force. This could be such a super historic shift in cancer treatment.

पृथ्वीं रक्ष, पृथ्वी त्वां रक्षति। #WorldEnvironmentDay #unep

Study proposes that chronic stress, depression, cardiovascular disease, poor sleep, and aging all increase dementia risk because they converge on a single biological bottleneck: the disruption of a sleep-dependent brain rhythm that clears metabolic waste. neurosciencenews.com/sleep-r…

source: sciencealert.com/age-related… paper: nature.com/articles/s41467-0…

Beautiful work in this paper. I think anatomy is often under-appreciated. I'm glad to see things like this #neurosicence 🧪🧠 An opposing molecular gradient axis underlies primate cortical organization | Science science.org/doi/10.1126/scie…

A single dose of engineered immune cells has helped two men and one woman to receive life-saving kidney transplants. Their bodies would normally reject donated organs. go.nature.com/4fZ8uoG

This standing ovation totally brought me to tears. On Thursday, my dad (stage 4 pancreatic cancer) started a Revolution Medicine trial building upon these results — RMC 5127, which uses the drug celebrated here, Daraxonrasib, with another drug targeting his specific KRAS mutation, G12V. He’s nearly 2 years into his fight with pancreatic cancer and we have personally felt the impact of this watershed moment. It is a lifeline. To the incredible, stalwart, brilliant researchers and folks bringing these discoveries to life - thank you. Thank you thank you thank you.

This is the silent part that people wouldn't know. Behind closed doors inside a medical conference, a large group of clinicians and researchers giving a standing ovation to another group of clinicians and researchers who found a way to increase survival in patients suffering from one of the, if not the, worst cancer in humans. Metastatic pancreatic cancer. They'll do this and then be on their way to see their patients the next day as if nothing happened. And then work on something new to better what they did in this room. That is how medical science works. Value it and value its practitioners.

For those of you who think macrophages do almost everything, rethink “almost.” They are programmable cells, recruited into whatever new function evolution needs. science.org/doi/10.1126/scie…