Targeting inflammaging in Alzheimer’s disease: molecular pathways and emerging pharmacotherapies link.springer.com/article/10…

Promises of reprogramming-induced rejuvenation sciencedirect.com/science/ar…

What people are missing about the US government's AI regulation announcement: ID verification will now be forced on all accounts to prove citizenship. Frontier labs will take your data, and your sovereignty is officially dead. A permanent underclass division and a total control society are beginning right now. People ignored me when I started saying this last year, but it is happening right in front of our eyes. Get into Open-Source and Sovereign AI. Advancing together through collective intelligence is the only way to fight back.

We are at a fork in the age of AI: either we will be pushed into a dystopian path where a few governments & corps will have access to powerful AI & the rest of us become enslaved with no hope to live, or continue to golden age path of living forever healthy in an abundant world…

Only a few 100s of people are working on aging - we need an Apollo scale effort

Sinclair's new preprint provides the first direct experimental evidence for the Information Theory of Aging: your cells don't age because they break — they age because they forget who they are. The biological blueprint is still intact. The cells just stop reading it correctly. That distinction changes the entire target: you don't repair damage. You restore data. And data can be restored.

This is interesting! Correcting the Exhaustion Paradigm for Robust NK Cell-tumor Eliminators youtu.be/fT9GLjzDuIw?si=veqs… via @YouTube

Happy now, @DarioAmodei? You got your wish for government regulation after constant fearmongering to slow AI progress. @AnthropicAI has done tremendous damage to AI advancement; they succeeded in realizing this nightmare scenario. It’s a sad & grave day for America & humanity.

This might be OpenAI or another AI company trying to gain a leg up on Anthropic and/or maybe trying its hand at regulation capture. In any case, this move is risky as heck. It threatens to derail the stock market, and with it, the economy.

The old world was built by scarce human genius. The next world will be built by endless synthetic genius. 1 000 000 more geniuses roughly means progress could become a million times faster. But let's be conservative and say it's "only" 100x - 1000x faster. That still gives you Star Trek level technology and wealth during the 2030s, not the 2330s.

Actually, they are members of the Golden Army. They are just waiting for Hellboy to show up (from Hellboy II: The Golden Army). PS. This post is supposed to be humorous.

A day to remember with my Moonshot Mate DB2! One of the most insightful conversations we've had about the future of humanity was held earlier this year at Tesla's Gigafactory. If you haven't yet watched it, here's your chance: youtube.com/watch?v=RSNuB9pj…

Some people are defending Anthropic despite everything that is happening, largely because Fable 5 is an amazing coding model. I can confirm this is true, and I do not think anyone would seriously argue against it. Even its high cost should not be an issue. We live under capitalism, and companies can charge what the market allows. But, and this is a very big but, there is a much more important issue here. What these people do not understand is that Fable will be the best coding model only for a short while. Others are very close behind. In fact, even better models will arrive soon, and coding itself is clearly on the path to being largely solved. Models will then become cheaper over time. If you do not get to build your amazing software a few months earlier, that probably will not change much in the world. At most, it may delay your personal ability to benefit from it for a while. It might even benefit you, by saving you from wasting money and time before better and cheaper versions arrive. But a doctor cannot wait to treat patients. A scientist trying to cure cancer does not have the luxury of waiting months. Every day of delay in research and clinical applications costs lives, potentially thousands of them. Every day that scientists around the world are denied access to the best models is another day the world is delayed from becoming better. And this is not only about model access. Anthropic has also advocated for pauses and regulatory capture. They are strongly against open models. In my view, this is not driven by some pure concern for humanity, but by the fact that such control would give them more money, more power, and more leverage over the future. Therefore, I believe it is far more important to be principled and stand for humanity than to chase short-term personal benefit. That is the reason for my outrage against Anthropic. It is nothing personal against poor Fable 5, or against the great AI engineers at Anthropic who are building these models. I do not doubt that many of them are sincere, and I am grateful to all frontier AI engineers who are pushing this technology forward. But I do hold those in charge of Anthropic responsible. Their founders and leadership should be held accountable for what I see as self-serving and deeply misanthropic actions. I also do not think they care. Not one of them has meaningfully responded to the outrage. This is also a note to everyone who keeps claiming that AI itself is the threat to human existence. No. It is not AI itself. It is the humans who control AI who may become the real threat to humanity, as I have said repeatedly. We have to resist this power capture at all costs, if we truly care about the rest of humanity.

70% increased lifespan in mouse model with #vaccine to #aging We @immortabio published this in collaboration with @BuckInstitute #longevity #vitalist #senovax #immortabio $IBRX link.springer.com/article/10…

With all the excitement going around, I'm looking for a summer research intern to help me with research to create the Abundance & Singularity Index. If you are a student or recent graduate with sharp research instincts, quantitative fluency, clear writing, AI-native workflows, and deep curiosity about abundance, exponential technologies, and the world of 2045, join me by applying today! hub.moonshots.com/internship

This could turn out to be a big milestone...

NEW PREPRINT: Scientists may have found direct evidence that aging is driven by the loss of cellular information, not just the accumulation of damage For decades we've focused on what aging cells accumulate. This paper focuses on what they lose: Information. Using a new technology called SeqTag, researchers measured gene expression, chromatin accessibility, and histone modifications in the same aging cells. What they found was striking: the regulatory systems that tell cells who they are become increasingly out of sync with age. The authors call this "molecular asynchrony." As cells age, chromatin structure, histone marks, and gene expression begin drifting apart. Regulatory entropy rises. Repressive chromatin erodes. Cells become less certain of their identity and more likely to drift toward alternative fates. This is what the Information Theory of Aging (ITOA) states: that aging occurs when cells lose epigenetic information, the instructions that tell the genome how to maintain youthful function. DNA may remain largely unchanged, but the system that reads it gradually loses fidelity. What's remarkable is that this paper doesn't just describe this phenomenon. It quantifies it. The authors measure increasing regulatory entropy, loss of H3K27me3-mediated repression, erosion of heterochromatin, weakening lineage fidelity, and increased cell-fate drift during aging. In progenitor cells, the barriers that normally preserve cellular identity become progressively weaker with age. Mechanistically, the study argues that aging is associated with increasing molecular asynchrony between chromatin accessibility, H3K27ac/H3K27me3 remodeling, and transcriptional state. This decoupling is accompanied by increased regulatory entropy, loss of repressive chromatin architecture, and weakening of lineage constraints. Genes affected are those involved in chromatin organization, DNA damage, and Wnt signaling, consistent with ITOA. Importantly, the authors provide quantitative evidence that age-related heterochromatin erosion lowers the energetic barriers that maintain cell identity, offering a potential mechanistic link between epigenetic information loss, cell-fate drift, and late-life disease susceptibility 👏

Yesterday, I had the privilege of speaking with a group of brilliant biotech innovators from around the world regarding what’s needed to accelerate American patients’ access to lifesaving innovation while allowing the US to maintain its leadership in these advances. After meeting with them, I’m even more convinced that the future is very bright.

This was a fun interview! Thank you @benwansell for a great chat.