This exact thing has weighed me down so many times, but I came up with a solution to it. Maybe it's a cope I use so that I don't wallow in despair, but I've always thought, "yeah, everything's been discovered, but not by me." I want the firsthand experience nonetheless.
So many discoveries are made because the top guys overlooked the little things as "past their knowledge". This is why you hear news of 6th graders finding new types of fishes because they're the only ones with enough childlike wonder left to love the game for the game's own sake and not get discouraged by the fact that "oh, there's no point, it's all been discovered", and what do they do? Discover something.
I don't think any scene of a movie ever captured the feeling of modernity colliding with the romanticism of the youthful human soul like this one. "Can't be done, nothing ever happens, nothing you can do" has been the mantra most of us were raised on.