Molecular biology researcher @exaibio. Genomics and RNA biology for cancer diagnostics. Previous head of @ucsddasl, @QueerScience_SD. PhD. 🏳️🌈
Joined July 2014
- Tweets 536
- Following 309
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71 Photos and videos
Pinned Tweet
4 May 2023
Now published! 📰
While the paper underwent review we added some cool results showing how Skipper can inform RNA-binding protein studies.
cell.com/cell-genomics/fullt…
github.com/YeoLab/skipper
10 Oct 2022
Searching for RNA-protein interactions?🔎
We @yeo_lab found more of them! 🎁
In our preprint we report >3x the number of interactions discovered by @EVNmoreRNA's CLIPper.
Our new method "Skipper" is available now! 🧵
biorxiv.org/content/10.1101/…
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3 Sep 2024
I had a great conversation that I’m so happy to share! Subscribe to the DASL pod, y’all.
3 Sep 2024
1/ 🎧 New Episode Alert! The first episode of the DASL Podcast is live! I chat with Dr. Evan Boyle, about his journey in RNA biology and his role in founding the Diversity and Science Lecture Series (DASL). #DASLPodcast @evaubo
buzzsprout.com/2398968/15653…
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Evan Boyle retweeted
14 Dec 2023
🔥🔥How does the LINE-1 retrotransposon jump around in the human genome? Super excited to present my postdoctoral work answering this published today @Nature
together with twitterless Kathy Collins's lab and @NogalesLab @UCBerkeley
nature.com/articles/s41586-0…
A 🧵
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Evan Boyle retweeted
5 Sep 2023
Graduate students are accusing the University of California of wage theft months after signing a contract that ended mass strikes. Some say they've been underpaid by $4k or more. What's going on? Check out my latest for @statnews
statnews.com/2023/09/05/univ…
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Evan Boyle retweeted
3 Sep 2023
Students and postdocs working at the intersection of RNA and cancer, there is still time to apply for short talks and travel awards #RNACancerSRC
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Evan Boyle retweeted
28 Jul 2023
Our work describing chromatin and gene expression programs in human scalp is now out in Nature Genetics. Congrats to Ben Ober-Reynolds and our other wonderful collaborators! nature.com/articles/s41588-0…
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Evan Boyle retweeted
18 Jul 2023
💛🐧yesterday, palmerpenguins reached 1 million CRAN downloads! The adoption & love this little data package has received over the past 3 years has been truly overwhelming. Here are some of my favorite (and maybe lesser known) moments from palmerpenguins’ history. 🧵1/11
ALT A line chart showing the cumulative downloads of palmerpenguins R package from CRAN, surpassing 1 million on 2023-07-17. The palmerpenguins hex logo is in the top right.
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15 Jun 2023
Fantastic!
15 Jun 2023
NEW! Our first @biorxivpreprint from @TheCrick, led by @megan_buckley01:
biorxiv.org/content/10.1101/…
"Saturation Genome Editing Resolves the Functional Spectrum of Pathogenic VHL Alleles"
We present a high-quality variant effect map of VHL to advance precision medicine.
(1/18)
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Evan Boyle retweeted
27 May 2023
A 🧵 on algorithms for predicting regulatory variant effects to help understand complex disease. IMO an extremely challenging problem that's at a glass mostly full / glass mostly empty point right now depending on who you ask.
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23 May 2023
Fantastic work! Everything I wanted after browsing gnomAD and seeing genes with few LOF variants with pLI/LOEUF scores I wasn't sure whether to trust.
Measures of gene constraint like pLI and LOEUF have been hugely useful in human genetics, but they lack power to detect constraint in the shortest 25% of genes. Here, we introduce an empirical Bayes framework (GeneBayes) to solve this problem. biorxiv.org/cgi/content/shor… 1/n
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16 May 2023
Very cool!
16 May 2023
Ever wondered how transient transcription factor DNA binding can robustly activate transcription? In this new preprint, we find support for one of the possible mechanisms: transcription factors exchange. A 🧵 1/9. biorxiv.org/content/10.1101/…
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4 May 2023
Now published! 📰
While the paper underwent review we added some cool results showing how Skipper can inform RNA-binding protein studies.
cell.com/cell-genomics/fullt…
github.com/YeoLab/skipper
10 Oct 2022
Searching for RNA-protein interactions?🔎
We @yeo_lab found more of them! 🎁
In our preprint we report >3x the number of interactions discovered by @EVNmoreRNA's CLIPper.
Our new method "Skipper" is available now! 🧵
biorxiv.org/content/10.1101/…
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4 May 2023
Also with @JackNaritomi we profiled binding of dominant negative Diamond-Blackfan anemia mutant RPS19. Surprisingly we saw an increase in CDS binding. Using Skipper's repetitive element output we also saw increased tRNA binding signal.
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4 May 2023
We also fixed some bugs in the code so it should be easier than ever to use Skipper to learn about how WT and mutant RBPs regulate genes co- and post-transcriptionally in human health and disease!
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Evan Boyle retweeted
16 Apr 2023
A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]
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Evan Boyle retweeted
11 Apr 2023
Scaling scRNA-seq data by log(p/s 1) outperforms other approaches, including recent methods with thousands of citations. [Ahlmann-Eltze & Huber, 2023 Nat Methods, nature.com/articles/s41592-0…]
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24 Mar 2023
Great progress!
24 Mar 2023
Update 🎉
NSF is taking a major step toward properly collecting data to improve LGBTQ equity in STEM. All PhD students in the US finishing in 2023-24 will be given LGBTQ questions in the survey required to graduate. Some concerns but almost there.
PDF: bit.ly/3LO5Z9I
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15 Mar 2023
Great article!
15 Mar 2023
Interesting piece: "After enduring severe nausea and vomiting in pregnancy, the geneticist Marlena Fejzo made finding the cause of her condition, hyperemesis gravidarum, her life’s work." nytimes.com/2023/03/14/well/…
The referenced GWAS: nature.com/articles/s41467-0…
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Evan Boyle retweeted
23 Dec 2022
So you're thinking about doing a #CRISPR screen...
@ENCODE_NIH is here to help! The CRISPR group is proud to share:
“Multi-center integrated analysis of non-coding CRISPR screens”
Lotsa great stuff inside for newbies and experts, here's a quick tour
biorxiv.org/content/10.1101/…
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