We are daughters, mothers, sisters, wives, lovers, and grandmothers. Let’s respect, support, uplift us.Embrace our strength and unity.Together, we can create a world that honors and values every woman's role and contribution. #RespectOurSex #RespectWomen

Delighted to share our latest review on 3D multi-omics tumor atlases. A major @theNCI #HTAN team work w/ @deniswirtz @AshleyKiemen @StimulatedRaman @SStevenWang, kudos to my phenomenal postdoc @Miao__Liu and co-contributors Jorge, Andre, & Xiaolong, on this team work! 🥰

The problem isn't that experts are challenged. It's that opinions and evidence are often treated as equals. Knowledge is hard earned. Confidence is free.

The luminescent world of phenoxazines, proving that chemistry knows how to light up a room.

Pakistan is my first and Last Love 🇵🇰💚 ChairPerson |Naujawan Qayadat Mazboot Roshan Pakistan 🇵🇰

HIF2 Drives Kawasaki-Like Coronary Vasculitis A longstanding mystery in Kawasaki disease (KD) is why some children develop catastrophic coronary artery aneurysms, thrombosis, and sudden cardiac death despite resolution of acute inflammation. A new Circulation study identifies HIF2α as a potential master regulator of this process. Using a novel vascular-specific genetic model, investigators show that chronic activation of HIF2 signaling is sufficient to trigger coronary remodeling, aneurysm formation, thrombosis, calcification, and lethal vascular rupture—closely recapitulating severe KD. The team deleted Vhl, the major negative regulator of hypoxia-inducible factors, in Wt1-lineage coronary vascular cells and cardiac fibroblasts. The result was dramatic: ✅ Progressive coronary artery dilation ✅ Coronary arteritis ✅ Elastin fragmentation ✅ Smooth muscle cell loss ✅ Intracoronary thrombosis ✅ Perivascular fibrosis ✅ Vascular calcification ✅ Sudden death between 15–20 weeks of age Importantly, systolic function remained largely preserved. The primary pathology was vascular—not myocardial failure. Mechanistically, HIF2 activation rewired multiple pathogenic programs simultaneously. Transcriptomic analyses revealed activation of: • Extracellular matrix remodeling • TGF-β signaling • Angiogenesis pathways • Coagulation programs • Inflammatory networks • Osteogenic/calcification pathways Key mediators included: ↑ MMP2 ↑ MMP9 ↑ TIMP1 ↑ PAI-1 ↑ Periostin (POSTN) ↑ Fibronectin (FN1) ↑ BMP2 ↑ Osteoprotegerin (OPG) These changes promoted elastin breakdown, arterial wall instability, thrombosis, and progressive aneurysmal remodeling. A particularly striking observation was the inflammatory phenotype. Affected coronary arteries accumulated: • CD68⁺ macrophages • MRP14⁺ neutrophils • MPO-rich inflammatory infiltrates • Increased IL-1β • Increased MCP-1/CCL2 • Increased CXCL1 The pathology strongly resembled human coronary vasculitis. Human validation The authors analyzed fatal KD autopsy specimens. Coronary aneurysm lesions demonstrated: 🔥 Strong HIF2α expression in: • Coronary media • Coronary intima • Perivascular inflammatory infiltrates • Macrophage-rich regions surrounding aneurysms In contrast, HIF1α expression was minimal or absent. This suggests that HIF2—not HIF1—may be the dominant hypoxia pathway driving coronary vascular injury in severe KD. The decisive experiment When investigators genetically removed Hif2a from the Vhl-deficient mice: ✓ Coronary dilation disappeared ✓ Thrombosis resolved ✓ Fibrosis normalized ✓ Inflammation vanished ✓ Cardiomegaly reversed ✓ Transcriptomic abnormalities largely returned to baseline Only seven genes remained differentially expressed versus controls. The disease phenotype essentially collapsed. Why this matters Current KD research focuses heavily on IL-1β, TNFα, and innate immunity. This study introduces a complementary framework: Hypoxia signaling may sit upstream of vascular remodeling, thrombosis, and aneurysm progression. HIF2 activation appears capable of integrating: • Inflammation • Matrix destruction • VSMC loss • Thrombosis • Calcification into a single disease-driving program. Because selective HIF2 inhibitors already exist clinically, the findings raise the possibility that HIF2-targeted therapy could eventually become a strategy for preventing coronary complications in severe Kawasaki disease and related vasculitides. Reference Escobar B, Menendez-Montes I, Albendea-Gomez T, et al. Activation of HIF2 in Cardiac Vasculature Leads to Arterial Remodeling, Dilation, Thrombosis, and Inflammation, Recapitulating Cardiac Involvement in Kawasaki Disease. Circulation. 2026. DOI: 10.1161/CIRCULATIONAHA.125.076230. #KawasakiDisease #HIF2 #CoronaryAneurysm #Vasculitis #CardioImmunology #VascularBiology #Hypoxia #Inflammation #Circulation #CardiovascularResearch

Who do you think is the best young leader of Pakistan for a stronger and brighter future? Vote now and share your opinion 1️⃣ Chairwoman Naujawan Qayadat Mazboot Roshan Pakistan Bio Sahiba2️⃣ Iqrar ul Hassan3️⃣ Jawad Ahmed4️⃣ Other Young Political Leader #Pakistan #YoungLeadership

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For osteoarthritis, Tai Chi improved pain, mobility, function, and stiffness, with effects similar to other exercise for most outcomes. 🧵 2/7

Across reviews of randomized trials, Tai Chi and related qigong practices showed broad but uneven health signals, especially for blood pressure, mobility, falls, and quality of life. 🧵 1/7

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733

#WomenInSTEM #Letsinnovategirls #Womeninscience #LetsEducategirls

A single psilocybin dose with support improved major depression symptoms.

Lifestyle change is the best-supported path for moving prediabetes back toward normal glucose—but the details matter. 🧵 1/7

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Sindhi, Balochi, Punjabi, Pashtun, Muhajir, and Kashmiri different cultures,different languages,but one identity: Pakistan. Our diversity is our strength, our unity is our pride. From the mountains of Kashmir to the deserts of Balochistan, every heartbeat for Pakistan 🇵🇰