A fascinating and unexpected discovery—who would have predicted that macrophages possess magnetic properties and can contribute to navigation through magnetoreception?science.org/doi/10.1126/scie…

Such a cool story! nature.com/articles/s41586-0…

Thrilled to see a new paper led by the outstanding @Brown_lab1, now out in Nature Biotechnology. We provide mechanistic insights into how mRNA vaccines work. challenging key assumptions and offering new ways to control vaccine activity. (1/3) Read here: nature.com/articles/s41587-0…

This #DayofImmunology, we celebrate the "Guardians of Immune Balance"—Regulatory T Cells! 🛡️ Did you know a cornerstone of the 2025 Nobel Prize-winning research on Tregs was published in The Journal of Immunology? In 1995, Shimon Sakaguchi and colleagues identified CD25 as a marker for these essential suppressor cells, forever changing our understanding of immune tolerance. 📖 Read the classic in @J_Immunol: ow.ly/kMyt50YRPHX.

Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. nature.com/articles/s41586-0… #immunology #cellbiology @immunox @ucsf

In 2021 we identified GZMK CD8 T cells as Taa - age-associated subset of cells in mice. How they developed remained unclear. Today, our latest work on the mechanism of development of age-associated GZMK CD8 Taa cells in old mice is now out! cell.com/cell-reports/fullte… "Inflammaging in aged tissues drives remodeling of the CD8 T cell compartment" let by Irina Shchukina and co-supervised by Gwendalyn Randolph with a huge team that helped to make it happen. We definitively show that: 1. GZMK Taa cell development is cell extrinsic and requires antigen exposure in aged tissues. 2. We introduce major new model that accelerates immune aging in CD8 T cells and show that low-grade inflammation accelerates CD8 T cell aging and Taa cell accumulation. 3. Aged adipose tissue acts as a niche that supports progenitor Taa cells and overall development of these cells.

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @RMedzhitov @YaleIBIO nature.com/articles/s41577-0…

Excited to share that our work by @PatFernRod & @TongWu99 is published: RORγt⁺ DCs are a distinct lymphoid-derived lineage whose development is controlled by REV-ERBα/β, PRDM16 and PU.1, enabling pTreg induction and protection from Th2-skewed responses. rb.gy/lyvce8

Bacteria’s babysitter role: Indole-driven immune truce in the womb Preview of @CellCellPress work showing maternal microbiota, specifically tryptophan derivatives produced by commensals, promote maternal tolerance of the fetus to improve pregnancy outcomes cell.com/cell-host-microbe/a…

New research involving human organoids and mice shows that crosstalk between commensal E. coli that express flagellin and intestinal epithelial cells coordinate intestinal #macrophage recruitment to support #GutBarrier homeostasis. scim.ag/4qjDMsI

⚠️ Research interrupted by 2025 funding cuts? AAI is here to help. Applications are now open for the second round of the AAI RESTORE Grants Program. We’re helping meritorious projects stay on track after unexpected grant terminations. 🔹 Who: Early-career researchers & PIs (R, K, F series, DP2/DP5, and more). 🗓️ Deadline: February 5, 2026. 💻 Apply: Log in to your AAI member account at members.aai.org/awards/aai-r…

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @J_Immunol 👇👇👇 academic.oup.com/jimmunol/ar…

Interested in immune development, placental and intestinal biology? We have two postgrad positions open in our group. Come join us.

We still don’t understand how T cells control tuberculosis. Our new paper shows that Mtb-specific T cells in NHP and human lung granulomas make many interesting effector molecules upon TCR stimulation. There’s a whole lot more to T cells in TB than IFNγ! cell.com/iscience/fulltext/S…

Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applications in both basic research and clinical practice. Learn more in The JI: ow.ly/i4SG50XAb6R.