Postdoctoral Research Fellow | @TheColonnaLab | Washington University in St. Louis
Joined May 2021
- Tweets 92
- Following 264
- Followers 179
- Likes 232
Photos and videos
Patrick Rodrigues retweeted
May 13
LIMmunity 2nd brew !!
Motherhood comes with superpower: pathogen protection!
nature.com/articles/s41586-0…
We often think moms are immunologically vulnerable to tolerate the baby. But I always wondered: why would evolution make such a critical period of life so dangerous?
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Patrick Rodrigues retweeted
Fachi, Trsan, Colonna et al. identify LINGO4 as a key regulator of ILC3s, coordinating mitochondrial fitness & IL-22 production. LINGO4 deficiency disrupts #ILC3 function & #microbiota composition, altering susceptibility to enteric infections hubs.la/Q04dLS_k0
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Patrick Rodrigues retweeted
Excited to share our latest work in J Exp Med! We identify LINGO4 as a key regulator of ILC3 fitness, IL-22 production and microbiota homeostasis, with major impact on host defense against enteric infection. Check it out!
doi.org/10.1084/jem.20252632
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🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴
sciencedirect.com/science/ar…
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Patrick Rodrigues retweeted
Our study is out in @ScienceMagazine! It shows that CAR-expressing astrocytes (CAR-A) can recognize and clear amyloid aggregates, reducing pathology and restoring microglial homeostasis in AD models.
Led by Yun Chen, Alex Liu and @khainotkaiorky!
doi.org/10.1126/science.ads3…
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Patrick Rodrigues retweeted
Platelet-derived growth factor D (#PDGFD) binds to PDGFRβ in #ILC3s in mice and NKp44 in human ILC3s, promoting divergent innate immune responses following intestinal infections. @TheColonnaLab
Learn more in Science #Immunology: scim.ag/4aXJmL1
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Patrick Rodrigues retweeted
Excited to share our new work in @SciImmunology, led by @zefachi! Mesenchymal cells produce PDGF-D during colitis, driving species-specific ILC3 programs: via PDGFRβ in mice (IL-22, repair) and NKp44 in humans (type I response, pathogen clearance).
science.org/eprint/EFDJ3BJRF…
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Patrick Rodrigues retweeted
Feb 27
PDGF-D engages PDGFRβ in mice and NKp44 in humans to drive ILC3 responses @SciImmunology
science.org/doi/10.1126/scii… @TheColonnaLab @zefachi
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Patrick Rodrigues retweeted
Jan 29
A distinct lymphoid progenitor generates RORγt DCs via a REV-ERB–controlled RORγt enhancer and PRDM16–PU.1-transcriptional programs @SciImmunology @TheColonnaLab @WashU
science.org/doi/10.1126/scii…
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Patrick Rodrigues retweeted
A new Science #Immunology study pinpoints the developmental origin of a distinct group of #DendriticCells that express the transcription factor #RORγt and highlights molecular players that regulate this process. scim.ag/45vKMue
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Patrick Rodrigues retweeted
Excited to share that our work by @PatFernRod & @TongWu99 is published: RORγt⁺ DCs are a distinct lymphoid-derived lineage whose development is controlled by REV-ERBα/β, PRDM16 and PU.1, enabling pTreg induction and protection from Th2-skewed responses.
rb.gy/lyvce8
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Patrick Rodrigues retweeted
25 Nov 2025
Excited to share our new paper in @JExpMed ! 🎉
We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (Trm) amplify antiviral protection during reinfection.
🧵👇1/6 x.com/JExpMed/status/1993389…
25 Nov 2025
.@ElenaHerndezGa1, @salva_iborra and colleagues @Unicomplutense show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. hubs.la/Q03VRyd40
#MucosalImmunology
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Patrick Rodrigues retweeted
21 Nov 2025
.@santosh73936311 et al. @TheColonnaLab @washu_pathology identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. hubs.la/Q03Vr4c90
@Dohyun_Kim_PhD @PatFernRod @RakiSudan
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Patrick Rodrigues retweeted
6 Oct 2025
BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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Patrick Rodrigues retweeted
12 Sep 2025
🚨 New preprint!
Generative modeling comes to cytometry.
Meet CytoVI — a deep generative model from the @YosefLab & @IdoAmitLab for antibody-based single-cell technologies (flow, mass cytometry, CITE-seq).
doi.org/10.1101/2025.09.07.6…
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🧵1/8 Happy to share my new preprint “ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.” I resolved why ID2 is essential for cDC1 lineage specification and uncovered a new paradigm of enhancers. Read here: researchsquare.com/article/r…
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Patrick Rodrigues retweeted
28 Aug 2025
Thrilled to share our new paper in @ScienceMagazine !
We identify septal LYVE1⁺ adipose macrophages (sATMs) as niche signals that control stem cell fate, restrain beiging & shape obesity susceptibility.
Team effort with @FGinhoux and collaborators.
science.org/doi/10.1126/scie…
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Patrick Rodrigues retweeted
24 Jul 2025
Happy to share our latest paper on DC ontogeny! nature.com/articles/s41590-0…
Congratulations to the team and to Dr Zhaoyuan Liu from the Shanghai Institute of Immunology!
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Patrick Rodrigues retweeted
24 Jul 2025
I'm excited to share our new study published in Cell.
This work uncovers a critical role for dural mast cells in shaping cerebrospinal fluid flow and protecting the brain from infection. cell.com/action/showPdf?pii=…
24 Jul 2025
Excited to share this new work from our lab, led by an exceptional graduate student, Tornike Mamuladze (@tornikemamu), on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis ||
authors.elsevier.com/sd/arti…
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Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP.
nature.com/articles/s41590-0…
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