PhD candidate studying transport mechanisms at Rockefeller University

Joined May 2011
10 Photos and videos
Gad retweeted
Excited to share our new work! We identified SLC33A1 as the major ER GSSG exporter that maintains redox balance in the ER lumen.
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…
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Gad retweeted
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…
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In @NatureCellBio: @KivancBirsoy's lab has discovered that the antioxidant glutathione plays a vital role in maintaining smooth operations of a protein-producing hub in the cell called the endoplasmic reticulum by acting as a protein “proofreader.” 🔗: bit.ly/3Ow8lxM
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Gad retweeted
Check out this amazing work by @shanshanliu1218 and @gadmark !
Apr 17
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s41556-0… 🧵 1/9
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Gad retweeted
Check out this impressive work and #tweetorial from @gadmark and @shanshanliu1218! If you’re interested in organellar metabolism and metabolite transport, this is a landmark paper on ER redox metabolism and transport👇
Apr 17
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s41556-0… 🧵 1/9
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Gad retweeted
Was an honor to contribute to this tremendous study co-led by the brilliant duo of @gadmark and @shanshanliu1218. Check out the thread below to learn more about how SLC33A1 works to maintain ER redox balance!
Apr 17
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s41556-0… 🧵 1/9
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Apr 17
Loss of SLC33A1 shifts PDIs toward oxidized states, triggers ER stress, and creates dependency on ERAD. Disease variants linked to Huppke-Brendel syndrome impair GSSG export. This work connects ER redox biology to neurodegeneration and cancer. 8/9
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Apr 17
Grateful to everyone who made this possible. Thank you to @shanshanliu1218, @KivancBirsoy, @HiteLabMSKCC, and all co-authors. Proud of what we discovered together across @RockefellerUniv and @MSKCancerCenter. 9/9
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Gad retweeted
California state reservoir levels are now at 130% of normal, holding 7 trillion gallons of water. Remarkable.
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Gad retweeted
Big congrats to @KivancBirsoy and @junyue_cao, who have both been promoted! rockefeller.edu/news/38607-f…

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8 Nov 2025
called it. read more at markgad.beehiiv.com/p/metser…
The FTC called Metsera and, apparently, told them that Pfizer was right about the structure of Novo's deal. Pfizer wins. prn.to/3WKm6ti
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Gad retweeted
Happy to see our recent work on SLC25A45 featured on the cover of @Cell_Metabolism. Huge thanks to @YuyangLiu1996 for the design! @KivancBirsoy @RockefellerUniv
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