Great study by @garedaba @StuartJoldham @jakob_seidlitz and colleagues, linking molecular and anatomical descriptions of the prenatal brain, now out in @NatureComms: Molecular signatures of cortical expansion in the human foetal brain 🧠🧬 nature.com/articles/s41467-0…

🧠New pre-print🧠 In this work we study cortical neurite and soma architecture over development using ultra-strong gradient dMRI 🧲 MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression: biorxiv.org/content/10.1101/…

Causal Cortical and Thalamic Connections in the Human Brain biorxiv.org/cgi/content/shor… #biorxiv_neursci

The developing Human Connectome Project fetal functional MRI release: Methods and data structures biorxiv.org/cgi/content/shor… #biorxiv_neursci

Gene regulatory landscape of cerebral cortex folding | Science Advances science.org/doi/10.1126/scia…

Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification biorxiv.org/cgi/content/shor… #biorxiv_neursci

Neurofibromatosis (#NF1) is a neurogenetic syndrome associated with learning impairments and a predisposition for glial tumors. We find that NF1 mutation causes an intrinsic deficit in oligodendrocyte precursor cell (OPC) differentiation. A thread 🧵 1/ nature.com/articles/s41593-0…

Introducing BrainMorph, a foundation model for general purpose brain MRI registration! BrainMorph is a robust tool that supports multi-modal, pairwise, and scalable groupwise registration via rigid, affine, and nonlinear transformations. 🧵1/5 👇 for code, models, and paper!

Cerebral Cortex meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition academic.oup.com/cercor/arti…

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution biorxiv.org/cgi/content/shor… #biorxiv_neursci

A collaboration with my neighboring lab is on Biorxiv. biorxiv.org/content/10.1101/… Dr. Jianglai Wu designed a curved light sheet microscope for high-speed, large-volume imaging. He imaged an entire intact cleared mouse brain at a voxel size of 0.625 × 0.625 × 1.25 μm3 within just 3 hours, eliminating the need for image tiling. This significantly saves time and, when combined with PEGASOS tissue clearing, allows for mesoscale projectome mapping at an unprecedented speed.

A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex science.org/doi/10.1126/scie…

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.02.15.5…

New preprint explores how rare high-effect gene-coding variants (#CNVs) shape brain architecture and influence cognitive and socio-behavioral traits in adolescents (#ABCD). medrxiv.org/content/10.1101/…

Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids biorxiv.org/cgi/content/shor… #biorxiv_neursci

This recent GWAS preprint is the first to explore genetic influences on the age at onset of walking 🚶‍♀️🚶, a milestone that may indicate broader (neuro)developmental delays. Find out more⤵️ medrxiv.org/content/10.1101/…

‼️We’re hiring! @CHOP_Research Seeking imaging/informatics folks and/or those passionate about human development/disease & imaging-genetics! Massive data sandbox (N>200k)! Highly collaborative & welcoming environment! DM/email or see us @OHBM @Aaron_A_B jobs.humanbrainmapping.org/j…

Development of thalamocortical connectivity during the third trimester biorxiv.org/cgi/content/shor… #biorxiv_neursci

Our preprint on thalamocortical connectivity in neonates is out!🧠👶 I'll do a summary later for those who have time to browse Twitter yet are too busy to read papers, but for now, I need a small break from thinking about this work😅#ittookovermylife biorxiv.org/content/10.1101/…

Today, I’m thrilled have our lab’s work featured on the cover of @Nature In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15 years ago when I was a postdoc and continued with later creating in the lab #organoid and then #assembloid models of this disease caused by a mutation in a calcium channel. Over time, these human cellular models and the biological insights we gained enable us to design a therapeutic strategy, which we validated in vivo following circuit integration of patient-derived organoids into the rat brain. Grateful for the incredible work led by @XiaoyuChenxy and @fikribirey in the lab! And the many close collaborators who participated to this line of research over the years.