Honored to be selected as a winner of the 2026 AMP Social Media Challenge and receive complimentary registration to #AMP2026 in Seattle! Thank you to AMP for this recognition and to the Molecular Genetic Pathology Fellowship Program at Massachusetts General Brigham/Harvard Medical School for fostering my growth in molecular pathology. Special thanks to Dr. Alanna Church for her mentorship and support. I am also grateful to Beth Israel Deaconess Medical Center/Harvard Medical School for supporting my intercalated Molecular Genetic Pathology fellowship training during residency. Looking forward to continuing to learn, share, and engage with the molecular pathology community. 🧬 #AMP2026 #MolecularPathology #AMPtutorials @BIDMCpath @MGBpathology

🎉 Congrats to Dr. Avash Das @avash22 for being the first winner of the 2026 #AMPtutorials (Social Media Challenge) hosted by @AMPath! 🏆 📢 Submit your entry now to win FREE registration to #AMP2026! amp.org/education/amp-molecu… ⏰ Submission deadline: August 31, 2026, at 2:59 PM Eastern. 🎯 TWO more winners will be announced in September! #MolecularPathology #PathX #PathTwitter

Congrats to @avash22, the first winner of our 2026 social media contest. His prize? Free registration to #AMP2026 in Seattle in November! 🥳 🧬 See his winning thread below. We'll name TWO more winners in September. Enter here by 8/31: amp.org/education/amp-molecu…. #AMPtutorials

This educational resource does not constitute medial or legal advise and is not intended for use in the diagnosis and treatment of individual conditions. #AMPtutorials #Molpath #path2path #PathX

(7/7): The discovery of mTOR is particularly fascinating: it began with the study of rapamycin, a natural product isolated from Streptomyces hygroscopicus on Easter Island, and led to the identification of a conserved pathway linking nutrients, growth factors, and energy status to cell growth. This work earned the 2017 Lasker Basic Medical Research Award, awarded to Michael N. Hall for uncovering TOR as a central regulator of cellular growth. #AMPtutorials #Molpath #path2path #PathX

(6/7): Burgeoning evidence shows durable responses to rapamycin analogs (rapalogs) in patients with heavily pretreated metastatic cancers harboring activating mTOR mutations. Accordingly, everolimus and temsirolimus are FDA-approved for certain cancers, and additional inhibitors are in development. However, FRB domain mutations confer resistance to allosteric inhibitors while retaining sensitivity to ATP-competitive kinase inhibitors—an important consideration for precision oncology. #AMPtutorials #Molpath #path2path #PathX

(5/7): In cancer, mTOR functions as a proto-oncogene, and its aberrant activation promotes tumorigenesis. Activating mTOR mutations have been identified in multiple malignancies, including clear cell renal cell carcinoma, endometrial carcinoma, anaplastic thyroid cancer, colorectal adenocarcinoma, and lung adenocarcinoma. These mutations occur across multiple domains and alter kinase activity directly or indirectly. Many clinical laboratories now use next-generation sequencing (NGS) assays to detect mTOR alterations. #AMPtutorials #Molpath #path2path #PathX

(4/7): The domain architecture of the mTOR protein includes N-terminal HEAT repeats that mediate protein–protein interactions and complex assembly, followed by a central FAT domain that contributes to structural stability and autoinhibitory regulation. Toward the C-terminus are the FRB domain (binding FKBP12–rapamycin), the catalytic kinase domain, and the FATC domain, which is essential for maintaining kinase activity and structural integrity. #AMPtutorials #Molpath #path2path #PathX

(3/7): Germline loss-of-function mutations in negative regulators of the mTOR pathway cause a group of dominantly inherited neurodevelopmental and hamartoma syndromes, collectively termed “mTORopathies.” These include Tuberous Sclerosis Complex (TSC), focal cortical dysplasia (FCDII), megalencephaly, and hemimegalencephaly, and are characterized by malformations of cortical development (MCD), often resulting in intractable epilepsy, autism, and intellectual disability. #AMPtutorials #Molpath #path2path #PathX

(2/7): mTOR assembles into two functionally distinct complexes: mTORC1, which responds to nutrients, energy status, growth factors, and stress to regulate protein synthesis, lipid metabolism, autophagy, and ribosome biogenesis; and mTORC2, which regulates cytoskeletal organization, cell survival, and AKT signaling. #AMPtutorials #Molpath #path2path #PathX

mTOR Tweetorial: (1/7): mTOR is a highly conserved gene that encodes a serine/threonine protein kinase functioning as a master regulator of cell growth, proliferation, metabolism, and autophagy. Genetic alterations in the mTOR pathway can lead to inherited germline disorders, while activating variants in mTOR can drive somatic malignancies. #AMPtutorials #Molpath #path2path #PathX

🚨 Submit #AMPtutorials to win FREE registration to #AMP2026 in Seattle! 🎓🏆 ➡️Instructions: amp.org/education/amp-molecu… @AMPath @pvhernandezmd @whosainastro @phuongn_nguyen @alexanderjneil #SocialMediaChallenge #MolPath

Participate in our #AMPtutorials contest for a chance to win free registration to #AMP2026 in Seattle! How to enter: amp.org/education/amp-molecu… The first round of judging begins 3/30!

Participate in our #AMPtutorials contest for a chance to win free registration to #AMP2026 in Seattle! How to enter: amp.org/education/amp-molecu… The first round of judging begins 3/30!

Participate in our #AMPtutorials scicomm contest on social media for a chance to win free registration to #AMP2026 in Seattle next year! How to enter: amp.org/education/amp-molecu… The first round of judging begins March 30!

Participate in our #AMPtutorials scicomm contest on social media for a chance to win free registration to #AMP2026 in Seattle next year! How to enter: amp.org/education/amp-molecu…

Participate in our #AMPtutorials scicomm contest on social media for a chance to win free registration to #AMP2026 in Seattle next year! How to enter: amp.org/education/amp-molecu…

🚨Don't miss the great opportunity to win FREE registration to #AMP2026 in Seattle! 🧬🧬Consider participating in the social media challenge by @AMPath. The first winner will be announced in March! 🏅🎉#AMPtutorials #SocialMediaChallenge #MolPath @pvhernandezmd @whosainastro @phuongn_nguyen @alexanderjneil

Participate in our #AMPtutorials scicomm contest on social media for a chance to win free registration to #AMP2026 in Seattle next year! How to enter: amp.org/education/amp-molecu…

🚨📗Consider writing a molecular pathology tutorial on social media for a chance to win free registration to #AMP2026 in Seattle! 🧬🧬 The first winner will be announced in March! 🎖️ #AMPtutorials #SocialMediaChallenge #MolPath @AMPath @pvhernandezmd @whosainastro @phuongn_nguyen @alexanderjneil