JAMA, 6月16日号(June 16)、痛みと緩和の観点からの推し(Keywords of Interest from a Pain and Palliative Care Perspective): 認知症(Dementia), ナラティブ・メディスン(NarrativeMedicine), 痛み(Pain), 睡眠補助薬(SleepAids), 死産(Stillbirth), 頭頸部癌(HeadNeckCancer),
Keyword:
臨床AI(ClinicalAI), 認知症(Dementia), ジゴキシン(Digoxin), ジギタリス(Digitalis), クライオ生検(Cryobiopsy), 1型糖尿病(Type1Diabetes), 薬剤公平性(Pharmacoequity), プライマリ・ケア(PrimaryCare), 肥満(Obesity), 340Bプログラム(340BProgram), 動物実験(AnimalTesting), ナラティブ・メディスン(NarrativeMedicine), 色素沈着(Hyperpigmentation), 痛み(Pain), 麻疹(Measles), ユージン・ブラウンワルド(EugeneBraunwald), GLP-1(GLP1), NSTEMI(NSTEMI), タンパク制限(ProteinRestriction), 睡眠補助薬(SleepAids), 公共図書館(PublicLibraries), 死産(Stillbirth), 頭頸部癌(HeadNeckCancer), 虫垂炎(Appendicitis), 膵管癒合不全(PancreasDivisum), JAMA(JAMA)
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Please sign this important petition: END ANIMAL EXPERIMENTATION IN NSW #AnimalResearch #NSW #Australia #AnimalTesting #AnimalCruelty #AnimalRights #primates 🐒 #EthicalScience @animaljusticeAU @AJPNSW @ajp_act @ajptas @AJP_Victoria @ajp_sa @AJP_WesternAust nsw.animaljusticeparty.org/e…
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Josephine Mitford Ⓥ 🌱 retweeted
Please sign the petition: END ANIMAL EXPERIMENTATION IN NSW 🐒🐒🐒 #AnimalResearch #primates #monkeys #AnimalTesting #AnimalCruelty #AnimalWelfare #AnimalRights #NSW #Australia #Wildlife #ethics #kindness @AJPNSW nsw.animaljusticeparty.org/e…
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Jun 15
The #Preclinical #DrugTesting playbook is being rewritten. 🔬
#FDA Modernization Act 3.0 → from #AnimalTesting to #organ-on-a-chip, #organoids & #AI.
~90% of animal-passed drugs still fail in humans. Human-relevant models change that.
#FDA #Biotech #Pharma #StartupFounders
ALT 1/ The biggest shift in drug safety testing in 80 years is underway. 🔬 FDA Modernization Act 3.0 - now advancing in Congress - eases the reliance on mandatory animal testing toward more human-relevant models. 2/ The replacement isn't one tool, it's a toolkit. New Approach Methodologies (NAMs): organ-on-a-chip, organoids, in-silico models, AI, omics, bioprinted tissue. 3/ Why it matters: ~90% of drugs that pass animal tests still fail in humans. NAMs promise more predictive data - faster, cheaper, less animal use. The catch: validation, whole-body complexity, and data quality remain real hurdles. 4/ My take: reward human-relevant science with a fast-track preclinical pathway - priority review for programs pairing a human-validated target with a human-tissue safety package.
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Jun 15
Ridglan Farms is officially shutting down. A lot of focus has been on beagles, but as we move away from dogs in research, what about other species?
On May 15th, High Quality Research in Fort Collins shut down thanks to the work of many individuals and groups.
These are some of the cats released to Kindness Ranch after that facility closed. They were bred at a place called Liberty Research, which sells them to labs for $1700 each.
In 2025, the USDA reported 12,632 cats held or used by research facilities. Of those, 1,274 were held and not used; 7,700 were used in procedures reported as causing no more than momentary pain/distress; 3,577 were used in painful/distressful procedures with pain relief; and 81 were used in painful/distressful procedures without pain relief because the drugs were said to interfere with the study.
Will boycotting products that test on animals help stop these experiments? I don’t want to discourage anyone from becoming a conscientious objector to animal exploitation. Boycotts can shift some consumer markets, but they will not, on their own, end vivarium-based biomedical research.
What kind of experiments are these cats used in? Were they fed Drano and laundry detergent? No.
They are used to study cat diseases like FIV, FeLV, FIP/coronaviruses, toxoplasmosis, cardiomyopathy, kidney disease, ophthalmic disease, and inherited neurologic diseases. FIV has also been used as a lentivirus model relevant to HIV/AIDS because of the biological similarities between FIV infection in cats and HIV infection in humans.
Historically, cats have been used in toxoplasmosis research because they are the definitive hosts for Toxoplasma gondii.
USDA’s own cat toxoplasmosis program became a major source of controversy and was discontinued in 2019 after public and congressional pressure; USDA ARS said it would not reinstate the use of cats in any ARS lab.
Most of us would not deny our cats vaccines, antivirals, antibiotics, anesthesia, or emergency care because animal studies were part of their development. Using these prevention and treatment measures does not make you a hypocrite, but it does show that consumer boycotts alone are not a complete theory of change.
Instead, we can seek to change how research is conducted to develop prevention and treatment for cats.
What if veterinary research followed a pediatric-style model: patients with naturally occurring disease, guardian consent, independent oversight, minimization of harm, and a realistic prospect of benefit?
Cats would not be confined to vivariums, but instead, when you bring your cat to a veterinarian for care, some of their diagnostics and treatments would be publicly funded for the benefit of society, and they would be entered into studies and their health would be monitored by researchers who are part of that study.
What other research are cats used for?
Cats have long been used in visual neuroscience because of their developed visual system and forward-facing eyes; classic kitten deprivation studies helped shape modern understanding of visual cortical development. Cats are also still used in auditory neuroscience, cochlear implant, and auditory nerve implant research, including surgical models for implanting devices into the feline auditory nerve.
How can we conduct this research in a way that is more clinically relevant and more aligned with unmet needs? By not purposefully harming cats in cages and instead providing diagnostics and care to human beings and other animals who currently lack access to medical care. How much information are we missing because we simply aren’t caring for those with existing visual and auditory impairments?
Cats are also used in some movement, gait, spinal cord injury, and neural control studies because their locomotion has historically been treated as a model for mammalian walking. Recent reporting described NIH-funded studies involving spinal cord injury and treadmill walking in cats, highlighting that some active cat experiments remain highly invasive. In vivarium-based settings, the spinal cords of cats are purposefully damaged for this research.
While working in a highly impacted animal shelter, every day I would care for cats suffering from paralysis, paresis or traumatic brain injuries. My staff would provide the best care they could, but if they didn’t make progress in a few days, they would be euthanized. What a missed opportunity for knowledge. How much might we learn if they were all afforded the diagnostics and care those purposefully harmed cats received in research settings?
Cats are also used in genetic disease and gene therapy models. Research cats are bred with naturally occurring or induced genetic disorders, including neurologic storage diseases, to test gene therapies. NIH project descriptions have cited feline gangliosidosis models as support for moving some AAV gene therapy approaches toward human clinical trials. What if we provided resources and diagnostics for cats with genetic disorders and tried gene therapy approaches on them?
Cats are also used in veterinary teaching, surgery, anesthesia, physiology, or clinical skills training. Instead, we can teach students on cats who actually need care, under the guidance of experienced veterinarians. Students learn more clinically relevant skills without wasting valuable time and resources on less productive teaching methods.
The biggest challenge society faces is not the lack of prevention and treatments for dreaded diseases, but the lack of access to existing prevention and treatments.
We now have a highly effective treatment for the formerly fatal cat disease feline infectious peritonitis (FIP). In the development of this treatment, many cats were purposefully infected and killed. Meanwhile, many more cats were euthanized in veterinary clinics across the country because there was no treatment available to them. What if we could bridge the gap between researchers and clinicians?
Sadly, though, now that there is a treatment, few people can afford it. Every cat who dies because of a lack of access to care should be considered just as much of a loss as a death due to a lack of a known cure.
Almost 2 billion humans, about one-third of the global population, lack regular access to essential medicines. Tuberculosis is now preventable and curable. Yet 1.23 million humans died from the disease in 2024.
By redirecting resources away from vivarium-based research and towards epidemiologic research, diagnostics, and access to care, we will be able to solve the biggest medical crises of our time for all species.
Simply boycotting products that test on animals, though an admirable endeavor, will not end vivarium-based research.
Many veterinarians and researchers are working on just that. Will you join us?
#ridglanbeagles #vetmed #animalresearch #animaltesting #animalexperimentation #animalwelfare #vetschool #vetstudent
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Jun 15
Big news for human-based science: The @NIH just launched ORIVA, a new office dedicated to advancing human-based, nonanimal research. This is a huge step forward for science that better reflects human biology and improves patient outcomes.
🔬 Read more: pcrm.org/news/news-releases/…
#HumanBasedResearch #NIH
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Jun 15
What a time to be alive - vegans pushed animal rights so far into the mainstream that right-wing politicians are capitalizing on their recent open rescue missions. This is incredible.
#veganism #govegan #rfk #secretarykennedy #trump #laratrump #ridglanfarms #beagles #animaltesting #maga #republicans #usa
Jun 15
Today @USDA @SecRollins and I secured a major win for animal welfare.
Ridglan Farms will transfer its remaining 475 beagles out of a research breeding facility and into the care of a no-kill rescue, where they can begin the path to adoption.
Thank you, @LaraLeaTrump, for championing this issue.
We are also launching a new @NIH office, ORIVA, to speed the transition away from animal testing and toward modern, human-based science.
We will keep fighting for humane treatment of animals, better science, and accountability.
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Jun 14
A new artificial intelligence tool has been created in Germany that could significantly reduce the number of animals used in preclinical drug research. 🐁🧪
Find out more ⬇️
veganfta.com/articles/2026/0…
#ai #crueltyfree #animaltesting
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#AnimalResearch News: New federal animal-use data analyzed; rescued chimps finally reach the woods; a major monkey supplier files for bankruptcy; record few Americans find #animaltesting morally acceptable. #animalrights #animalcruelty riseforanimals.org/news/news… via @rise_foranimals
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Jun 12
Beagles are STILL being used for testing @CRiverLabs at 55 Union St in Worcester, MA, this is a MA DPH issued license and they are violating the Beagle Bill #Dogs #AnimalTesting
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Summary of ECHA's 6th Report on Alternatives to Animal Testing for REACH Regulation.
Read more >> bluefrogscientific.com/chemi…
#AnimalTesting #NAMs #ReadAcross #QSAR #REACH #EUREACH #UKREACH #ChemicalRegulation
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Jun 11
The @EU_Commission has taken another significant step toward modernizing biomedical research and safety assessment with its newly released roadmap for phasing out animal testing under the REACH framework.
This initiative outlines a coordinated strategy to accelerate the development, validation, and regulatory acceptance of New Approach Methodologies (NAMs), reinforcing a growing commitment to more human-relevant science across Europe, and joining a worldwide movement now including:
🇺🇲 USA: bit.ly/441TgYK
🇬🇧 UK: bit.ly/4emJjdj
🇯🇵 Japan: bit.ly/3QB2SXt
🇪🇺 Europe: bit.ly/3Sz07X8
@iOrganBio is helping our partners across the globe navigate this rapidly evolving NAMs landscape by enabling rapid protocol discovery and process development with CellDiscovery™ and scalable cell and organoid manufacturing using CellForge™.
With in vitro model quality and consistency more important than ever, we’re proud to be delivering The Right Cells, Consistently, At Scale.
🌐 Learn more about our technology at iorgan.bio
#NAMs #Organoids #AnimalTesting #DrugDevelopment #EU
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جانوروں پر آزمائشیں کرنے کے بجائے جنسی زیادتی کرنیوالوں پر کی جائیں: مریم نفیس
nawaiwaqt.com.pk/11-Jun-2026…
#MariamNafees #AnimalRights #AnimalTesting #HumanRights #SocialIssues #Justice
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