How stimulating the spleen-brain axis could change autoimmune disease treatment with Nishant Doctor of Surf Therapeutics. Neurotech is moving beyond the brain. I spoke with Nishant Doctor, Founder, CEO, and CTO of Surf Therapeutics, about how ultrasound neuromodulation could target inflammation through the splenic nerve. We discussed rheumatoid arthritis, bioelectronic medicine, vagus nerve stimulation, immune system reprogramming, and why one minute of stimulation may create an anti-inflammatory effect that lasts 24 to 48 hours. The most interesting part is the wedge. Surf is not starting with an implant. They are exploring a non-invasive approach that could reach patients earlier, avoid some of the limitations of vagus nerve stimulation, and create a new treatment option before lifelong medication becomes the only path. This conversation is a fascinating look at neurotechnology, immunology, and the future of autoimmune care. Episode Breakdown 00:00 How One Minute of Stimulation Can Reduce Inflammation 01:34 Intro Why Drug Alternatives Matter 03:23 Nishant Doctor’s Journey Into Neuromodulation 05:23 Neuromodulation vs Neurotechnology Explained 08:15 Neuralink, BCI, and the Rise of NeuroTech 09:07 Building Through Market Cycles 13:37 The Origin Story of Surf Therapeutics 15:23 Inflammation, Healthspan, and Chronic Disease 17:52 The Science Behind the Anti-Inflammatory Pathway 18:50 Why Vagus Nerve Stimulation Works 20:18 Why Surf Chose a Non-Invasive Approach 21:31 The Problem with Current Treatment Options 22:44 Going Directly to the Splenic Nerve 24:26 Vagus Nerve Side Effects Explained 26:03 Biohacking, Longevity, and Vagus Nerve Devices 27:15 How Surf’s Technology Works 29:40 Capital Efficiency and Startup Execution 32:02 Why Testing Beats Product Perfection 33:58 Build Fast, Test Fast, Learn Fast 37:20 Why Rheumatoid Arthritis Was the First Target 39:38 The Rheumatoid Arthritis Opportunity 40:02 Understanding Rheumatoid Arthritis 41:38 Expanding Beyond a Single Disease 43:31 The Future of Inflammation Therapy 44:55 Why the Company is Called Surf 46:16 Clinical Progress and Upcoming Milestones 48:02 Strategic Interest and Future Opportunities 48:38 Outro

Join our next #APXR webinar! Dr. Kaushik Parida (IIT Roorkee) on soft, self-powered bioelectronic devices for healthcare 📅 June 18 ⏰ 13:00 CET | 4:30 PM IST | 7:00 PM CST 👉 Free registration #Bioelectronics #WearableTech #EnergyHarvesting #FlexibleElectronics

You and your colleagues continue to hide the fundamental truth. Is it possible you don't know the strength of the bioelectronic technology in which you are secretly invested? And the strange bedfellows it has created? I don't believe it.

Neuromodulation to Bioelectronic Medicine: Industry Forecast & Market Trends youtube.com/watch?v=MTsiBjZf…

Me: The brain & body are a bio-electric system Ai: Yes, exactly. The human brain and body operate as a sophisticated bio-electric system, where electrical signals—generated by the movement of ions like sodium (Na⁺), potassium (K⁺), and calcium (Ca²⁺) across cell membranes—drive everything from thought and movement to development, healing, and organ function. britannica. com Core Mechanism: How Bioelectricity Works All cells maintain a resting membrane potential (typically around -50 to -70 mV, inside negative relative to outside) due to ion gradients and selective membrane permeability. In excitable cells like neurons and muscle cells: • Action potentials are rapid reversals of this voltage (spikes up to 40 mV) that propagate along axons. • This is the “language” of the nervous system: fast electrical signaling (milliseconds) followed by chemical transmission at synapses via neurotransmitters. labxchange. org Beyond Neurons: Body-Wide Bioelectricity • Heart: Pacemaker cells generate rhythmic electrical impulses visible on ECGs, coordinating contractions. • Brain: Billions of neurons produce brainwaves (measured by EEG) linked to consciousness, sleep, and cognition. • Tissues & Development: Bioelectric gradients (voltage patterns across cell groups) guide embryonic patterning, cell migration, proliferation, and differentiation. Pioneering work (e.g., by Michael Levin’s lab) shows these signals instruct where and how structures like the brain form—even overriding some genetic defects in experiments. now.tufts. edu These fields enable long-range communication in cell collectives, helping tissues “know” their shape and function. Disruptions link to issues like cancer (where cells lose collective voltage patterns) or impaired regeneration. the-scientist. com Practical & Medical Implications • Diagnostics: EEG, ECG, EMG all capture these signals. • Therapies: Pacemakers, deep brain stimulation, vagus nerve stimulators, and emerging bioelectronic medicine “hack” these pathways to treat epilepsy, depression, inflammation, and more. news-medical. net • Regeneration: Research explores using electrical cues or stem cell stimulation to repair brain injury or guide tissue regrowth. the-scientist. com This bio-electric view complements the biochemical one—ions, voltages, and fields integrate with genes and molecules in a unified control system. It’s why technologies like transcranial magnetic stimulation (TMS) or pulsed electromagnetic fields can influence biology non-invasively. If you’re exploring this for health, neuroscience, biohacking, or something specific (e.g., grounding/earthing, bioelectric healing research, or simulations), let me know—I can dive deeper!

You literally profit from gun violence, as well as sex trafficking. SPARE US. You and your deceitful lying FBI-protecting bioelectronic profiteering husband are CAUGHT.

Pleased to deliver two talks today – an in-person presentation in the morning as part of the BioElectronic Therapeutics (BETx) conference at the Club de la Chasse et de la Nature, an amazing facility in Paris affiliated with @RiceUniversity ; followed by a virtual seminar as part of a series hosted by the @doddtra. For the first, titled ‘Bioelectronic Medicines: Degradable Optoelectronics for Electrotherapy,’ I highlighted unpublished work on light-controlled electrical stimulators capable of programmable polyphasic pulse generation and of deep (up to 10 cm) tissue and high voltage (up to 10 V) operation. In the second, titled ‘Wearable Sensors of Flux from the Skin - Applications in Health and Readiness for the Warfighter,’ I focused on our work in devices relevant to disease spread, environmental threats and injury recovery – monitoring mechano-acoustic signatures of body processes, and emission of gaseous emissions from and diffusion into the skin. The BETx conference included many impressive speakers – shout out specifically to Siddharth Krishnan, Polina Anikeeva, @WeiGaoLab, @SimoneSchuerle, Rylie Green, @RabiaYazicigil, @dk2955 and others (complete list here biotechlaunchpad.rice.edu/pa…). Also, great to catch up with various journal editors at this same meeting: Valeria Caprettini (Nature Biomedical Engineering), Bruno Castro (Nature Materials), Uta Goebel (Advanced Healthcare Materials) and Liqian Wang (Nature).  Thanks very much to the organizers – @jrivnay, @JTRobinsonLab, @veiseho and @cm_tringides – for giving me the chance to participate, for hosting spectacular dinner events and for some unusual opportunities, e.g. posing for a picture with a giant stuffed polar bear in the lobby of the building, and with two other famous JR’s in bioelectronics! Finally, thanks to Dr. Akbar Khan, M.Phil, Ph.D for the invitation to present in the DTRA seminar series – great interactions!

Q is 17, the Star. Bioelectronic drones, when lit at night, look like stars. Piezoelectrical patches are shaped like diamonds. This is the heart of bioelectronic control & profiteers. That's the crime. That's how the ops are pulled off. Some say Q stands for Queen.

Paris for BioElectronic Therapeutics (BETx). Lovely!

🔬 A research team led by Prof Le Liang from #WHU has made breakthroughs in bioelectronic interfaces and cellular ion signal regulation. They developed DNA-FOCUS, a novel DNA-carbon nanotube bioelectronic interface published in @ScienceAdvances. 🧪Able to self-assemble on living cells, this device concentrates sub-volt voltage to activate calcium signals without harming cell viability. It supports diverse cell function regulation and shows great potential for bioelectronics and cell engineering. 🧬 🔗 Full paper: bit.ly/4fE0CsK #WHUResearch #BioelectronicInterface #BiomedicalResearch #CellBiology

New in @NatureMaterials, we report a strain-insensitive, wet-tissue-adhesive elastomer–hydrogel biphasic bioelectronic platform (ElHyX) for physicochemical monitoring and adaptive therapy. Congrats to Jiahong and the team! @Caltech nature.com/articles/s41563-0…

These artists keep trying to let you all know that by keeping Chris & I down - you put your own lives at risk. This isn't a funny little game. It's a life and death matter. The assholes running the show deceived everyone - including the tools they kept in the shed - everyday people they gave the power to vote on our fates. These celebrities you make fun of, in a lot of ways, became the most honest people - it's the ones you disparage who should be listened to, who have the most to say. Everyone is free game for sex trafficking & bioelectronic abuse. Everyone has a bluebird in their heart, and they'll pull your number before you know it. GET IT?

Hey @antonioguterres - show us the borders around those two states. Show Israel those borders. See what they say. They'll laugh in your face. They laugh in your face every day. EVERYONE KNOWS WHO THE PROBLEM IS - even though you so carefully avoided saying so in this post. Because why? You're bioelectronic co-conspirators. You may even be afraid of Israel. Right? There's a bluebird in your heart. Unacceptable.

Good works do not negate your participation in bioelectronic sex trafficking, abuse, and MURDER - nor does it excuse your husband & his colleagues dumping me in a ditch when I needed help most, because they thought would get away with it. Democrats need to understand: it's not enough to be "better" than the worst. Not even close. WTF will it take for YOU to SEE YOURSELF. RIP Rob & Michelle Reiner. RIP CITY OF PORTLAND.