The MRNA shot was all in preparation to get people to start producing these synthetic antibodies. See its the brightness of the luminescence that powers these Beast System.
Here how I know this for a fact.
mRNA sequences utilizing fusion proteins generally INVOLVE CODING SEQUENCES INSERTED between the 5' and 3' untranslated regions (UTRs) of the mRNA transcript, often linked by peptide linkers or signal peptides to ensure proper folding and secretion.
For example, in vaccine design, codon-optimized sequences for distinct antigens (such as the A35R and M1R monkeypox virus antigens) are fused into a single mRNA to create a bivalent vaccine that enhances immunogenicity compared to separate mRNA injections.
pmc.ncbi.nlm.nih.gov/article…
Essentially the Antigens are synthetic cleverly hidden under the disguise of Antibodies. Here's how we know.
IgG4 Antibodies
Currently, their preparation RELIES ON GENETIC FUSION OF LUCIFERASES TO ANTIBODIES or nonspecific chemical conjugation strategies
Bioluminescent Antibodies through Photoconjugation of Protein G–Luciferase Fusion Proteins
pubs.acs.org/doi/10.1021/acs…
The luminescence from these luciferase fused antibodies powers the bacteria that's being used as nanobots.
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“At Constructive Bio we rewrite life's code to turn cells into sustainable bio factories.”
Syn61
addgene.org/174513/
Syn61 is a fully synthetic, genomically recoded strain of E. coli bacteria developed by researchers @ the MRC Laboratory of Molecular Biology. By rewriting the 4-million base-pair genome, scientists removed 3 of the 64 genetic codons (TCG, TCA, & TAG) & replaced them w/ synonyms, freeing up those codons to encode non-canonical amino acids.
pmc.ncbi.nlm.nih.gov/article…
Syn61 serves as the technological foundation for commercial platforms like Constructive Bio, which utilizes these recoded bacterial strains as programmable biofactories. The platform is used for large-scale fermentation-based production of complex molecules.
constructive.bio/publication…
Additionally, specific laboratory strains of Syn61 are actively used in academic research & are available to the scientific community via repositories like Addgene.
Syn61Δ3(ev5)
From the Syn61 strain (Addgene #174513), 2 rounds of parallel mutagenesis & dynamic selection were followed by deletion of the serT, serU & prfA genes, & a further 3 rounds of parallel mutagenesis & dynamic selection yielded Syn61Δ3(ev5) (Addgene #174514).
addgene.org/174514/
Syn61Δ3(ev5) ΔrecA (ev1)
Laboratory adapted, genomically recoded E. coli strain w/out TCG, TCA, or TAG codons & deleted serT, serU, prfA, & recA genes. Evolved for ~270 generations in LB @ 37 °C.
addgene.org/189857/
Syn57
Syn57 is a radically engineered strain of E. coli bacteria w/ the most compressed & heavily recoded genetic code ever created. While Syn61 removed three codons from the standard 64-codon universal genetic code, Syn57 pushes the boundaries further by eliminating 7 codons, forcing the organism to function using only 57.
To build Syn57, researchers systematically rewrote a 4-megabase E. coli genome to replace 105,000 specific genetic targets.
They altered:
🔸Four Serine codons (compressing the standard 6-codon serine block down to 2)
🔸Two Alanine codons (compressing the standard 4-codon alanine block down to 2)
🔸The Amber stop codon (TAG, replaced by TAA)
Every single instance of these 7 codons across the entire genome had to be substituted w/ a biological "synonym" while keeping the bacteria completely alive & functioning.
biorxiv.org/content/10.1101/…
Design, synthesis, & testing toward a 57-codon genome
addgene.org/browse/article/2…
pYES1L-URA
(Empty Backbone) E.coli shuttle vector for large-scale DNA assembly in S. cerevisiae.
addgene.org/84301/
Transplant of human chromosomes marks first step in genome synthesis project
This new research paper outlines this pipeline & demonstrates the critical first step in it:
bookcafe.yuntsg.com/ueditor/…
The transplantation of human chromosomes into an ‘assembly cell’, exemplified by a mouse embryonic stem cell (mESC). In the mESC the human chromosome can be manipulated & recoded w/out the complexities of working directly in a human cell, which contains two copies of each chromosome. The isolated chromosome can then be transferred back from the mESC to a recipient human cell & the corresponding ‘spare’ copy eliminated from the recipient, leaving the usual 2 copies. Crucially, the team demonstrated that this can be achieved w/out chromosome damage.
In future work, this ‘assembly cell’ stage of the pipeline WILL BE UTILISED TO REWRITE THE GENETIC INFORMATION ON THE HUMAN CHROMOSOME W/ SYNTHETIC SEQUENCE.
This work was funded by the Wellcome Trust & the UK Medical Research Council w/ additional support from the Boehringer Ingelheim Fonds, the Cambridge Commonwealth, European & International Trust & Marie Skłodowska-Curie Actions.
mrclmb.ac.uk/news-events/art…
An adaptable, plug-and-play application of genetic code expansion (GCE) technology for the rapid, modular creation of bispecific nanobody conjugates from non-canonical amino acid (ncAA)- integrated nanobody domains, offering precise control over domain topology.
biorxiv.org/content/10.1101/…
SynHG (Synthetic Human Genome)
SynHG is aiming to develop the foundational & scalable tools, tech & methods needed to synthesise human genomes.
mrc-lmb.cam.ac.uk/sites/synh…
Constructive Bio
Uses the world’s first fully synthetic recoded organism to produce therapeutics w/ chemistries that natural biology cannot access.
constructive.bio/
Genetic Code Expansion Platform
The platform enables fermentation-based production of peptides & proteins containing hundreds of non-canonical amino acids.
Transform natural cells into programmable biofactories w/ expanded chemical capabilities.
constructive.bio/platform
BioForge
Constructive Bio’s industrial fermentation platform for manufacturing peptide & protein therapeutics containing up to 3 different non-canonical amino acids per molecule.
constructive.bio/bioforge
Non-canonical amino acids (ncAAs)
ncAAs expand the chemical properties available to peptides & proteins beyond the 20 standard amino acids.
BIOLOGY GIVES U 20 BUILDING BLOCKS. WE GIVE U HUNDREDS MORE!
We engineer orthogonal aminoacyl-tRNA synthetases (aaRS) that selectively charge non-canonical amino acids onto dedicated tRNAs. These engineered aaRS–tRNA pairs work alongside the cell's native translation machinery w/out cross-reacting, enabling site-specific incorporation of ncAAs into peptides & proteins during standard fermentation.
constructive.bio/ncaa
Pipeline
The pipeline applies the platform to novel peptide & protein therapeutics, from discovery to clinic.
Enabling robust, reliable bioproduction w/ our phage-resistant Syn61 platform for industrial-scale manufacturing.
Our Syn61 chassis provides inherent resistance to bacteriophage contamination, a critical advantage for industrial biomanufacturing where phage infection can cause catastrophic production failures.
constructive.bio/pipeline
Publications
constructive.bio/publication…
By combining fully synthetic genomes w/ precisely engineered genetic codes & orthogonal translation machinery, his teams are enabling cells to synthesise entirely new classes of molecules: polymers w/ properties unattainable by natural chemistry, sequence-defined non-canonical biopolymers, & therapeutics that operate far beyond the limits of ribosomal biosynthesis as we know it.
At the heart of the discussion stands Syn61 – now widely regarded as one of the landmark achievements in the history of genome engineering. Syn61 was the clearest demonstration to date that life can be liberated from the universal code that has governed biology for billions of years. It was followed by Syn57. Thru meticulous, genome-wide recoding, Chin’s team compressed the canonical 64-codon genetic code into a streamlined 57-codon framework. As a result, Syn57 is THE LARGEST DELIBERATE REWRITE OF A LIVING GENOME EVER ACCOMPLISHED.
As Chin explains, Syn61 & Syn57 are more than a technical tour de force – they demonstrate the foundational platform for a new era of biological programming. FREED CODONS CAN NOW BE REASSIGNED @ WILL, OPENING VAST CHEMICAL SPACE FOR INCORPORATING NON-CANONICAL AMINO ACIDS, creating genetic firewalls, & ultimately DESIGNING ORGANISMS WHOSE BIOCHEMISTRY OPERATES UNDER RULES WE DEFINE.
constructive.bio/news/synbio…
The tech begins w/ assembling large, synthetic DNA fragments that replace megabase-scale sections of an organism's natural genome. W/in these synthetic DNA constructs, specific redundant genetic codons are entirely removed. This frees up those codons & their associated cellular machinery—such as tRNAs & aminoacyl-tRNA synthetases. By introducing new tRNAs & synthetases, the cell's translational system is re-purposed to recognize these free codons & assign them to entirely new, non-natural monomers.
The result is a "recoded" organism capable of sustainably building unique polymers @ scale, extending far beyond nature's standard 20 amino acids. These non-canonical polymers can be endowed w/ enhanced properties in new materials & therapeutics.
synbiobeta.com/read/construc…
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1,539
SynHG (Synthetic Human Genome)
SynHG is aiming to develop the foundational & scalable tools, tech & methods needed to synthesise human genomes.
mrc-lmb.cam.ac.uk/sites/synh…
Constructive Bio
Uses the world’s first fully synthetic recoded organism to produce therapeutics w/ chemistries that natural biology cannot access.
constructive.bio/
Genetic Code Expansion Platform
The platform enables fermentation-based production of peptides & proteins containing hundreds of non-canonical amino acids.
Transform natural cells into programmable biofactories w/ expanded chemical capabilities.
constructive.bio/platform
BioForge
Constructive Bio’s industrial fermentation platform for manufacturing peptide & protein therapeutics containing up to 3 different non-canonical amino acids per molecule.
constructive.bio/bioforge
Non-canonical amino acids (ncAAs)
ncAAs expand the chemical properties available to peptides & proteins beyond the 20 standard amino acids.
BIOLOGY GIVES U 20 BUILDING BLOCKS. WE GIVE U HUNDREDS MORE!
We engineer orthogonal aminoacyl-tRNA synthetases (aaRS) that selectively charge non-canonical amino acids onto dedicated tRNAs. These engineered aaRS–tRNA pairs work alongside the cell's native translation machinery w/out cross-reacting, enabling site-specific incorporation of ncAAs into peptides & proteins during standard fermentation.
constructive.bio/ncaa
Pipeline
The pipeline applies the platform to novel peptide & protein therapeutics, from discovery to clinic.
Enabling robust, reliable bioproduction w/ our phage-resistant Syn61 platform for industrial-scale manufacturing.
Our Syn61 chassis provides inherent resistance to bacteriophage contamination, a critical advantage for industrial biomanufacturing where phage infection can cause catastrophic production failures.
constructive.bio/pipeline
Publications
constructive.bio/publication…
By combining fully synthetic genomes w/ precisely engineered genetic codes & orthogonal translation machinery, his teams are enabling cells to synthesise entirely new classes of molecules: polymers w/ properties unattainable by natural chemistry, sequence-defined non-canonical biopolymers, & therapeutics that operate far beyond the limits of ribosomal biosynthesis as we know it.
At the heart of the discussion stands Syn61 – now widely regarded as one of the landmark achievements in the history of genome engineering. Syn61 was the clearest demonstration to date that life can be liberated from the universal code that has governed biology for billions of years. It was followed by Syn57. Thru meticulous, genome-wide recoding, Chin’s team compressed the canonical 64-codon genetic code into a streamlined 57-codon framework. As a result, Syn57 is THE LARGEST DELIBERATE REWRITE OF A LIVING GENOME EVER ACCOMPLISHED.
As Chin explains, Syn61 & Syn57 are more than a technical tour de force – they demonstrate the foundational platform for a new era of biological programming. FREED CODONS CAN NOW BE REASSIGNED @ WILL, OPENING VAST CHEMICAL SPACE FOR INCORPORATING NON-CANONICAL AMINO ACIDS, creating genetic firewalls, & ultimately DESIGNING ORGANISMS WHOSE BIOCHEMISTRY OPERATES UNDER RULES WE DEFINE.
constructive.bio/news/synbio…
The tech begins w/ assembling large, synthetic DNA fragments that replace megabase-scale sections of an organism's natural genome. W/in these synthetic DNA constructs, specific redundant genetic codons are entirely removed. This frees up those codons & their associated cellular machinery—such as tRNAs & aminoacyl-tRNA synthetases. By introducing new tRNAs & synthetases, the cell's translational system is re-purposed to recognize these free codons & assign them to entirely new, non-natural monomers.
The result is a "recoded" organism capable of sustainably building unique polymers @ scale, extending far beyond nature's standard 20 amino acids. These non-canonical polymers can be endowed w/ enhanced properties in new materials & therapeutics.
synbiobeta.com/read/construc…
2
19
26
2,725
SynHG (Synthetic Human Genome)
SynHG is aiming to develop the foundational & scalable tools, tech & methods needed to synthesise human genomes.
mrc-lmb.cam.ac.uk/sites/synh…
Constructive Bio
Uses the world’s first fully synthetic recoded organism to produce therapeutics w/ chemistries that natural biology cannot access.
constructive.bio/
Genetic Code Expansion Platform
The platform enables fermentation-based production of peptides & proteins containing hundreds of non-canonical amino acids.
Transform natural cells into programmable biofactories w/ expanded chemical capabilities.
constructive.bio/platform
BioForge
Constructive Bio’s industrial fermentation platform for manufacturing peptide & protein therapeutics containing up to 3 different non-canonical amino acids per molecule.
constructive.bio/bioforge
Non-canonical amino acids (ncAAs)
ncAAs expand the chemical properties available to peptides & proteins beyond the 20 standard amino acids.
BIOLOGY GIVES U 20 BUILDING BLOCKS. WE GIVE U HUNDREDS MORE!
We engineer orthogonal aminoacyl-tRNA synthetases (aaRS) that selectively charge non-canonical amino acids onto dedicated tRNAs. These engineered aaRS–tRNA pairs work alongside the cell's native translation machinery w/out cross-reacting, enabling site-specific incorporation of ncAAs into peptides & proteins during standard fermentation.
constructive.bio/ncaa
Pipeline
The pipeline applies the platform to novel peptide & protein therapeutics, from discovery to clinic.
Enabling robust, reliable bioproduction w/ our phage-resistant Syn61 platform for industrial-scale manufacturing.
Our Syn61 chassis provides inherent resistance to bacteriophage contamination, a critical advantage for industrial biomanufacturing where phage infection can cause catastrophic production failures.
constructive.bio/pipeline
Publications
constructive.bio/publication…
By combining fully synthetic genomes w/ precisely engineered genetic codes & orthogonal translation machinery, his teams are enabling cells to synthesise entirely new classes of molecules: polymers w/ properties unattainable by natural chemistry, sequence-defined non-canonical biopolymers, & therapeutics that operate far beyond the limits of ribosomal biosynthesis as we know it.
At the heart of the discussion stands Syn61 – now widely regarded as one of the landmark achievements in the history of genome engineering. Syn61 was the clearest demonstration to date that life can be liberated from the universal code that has governed biology for billions of years. It was followed by Syn57. Thru meticulous, genome-wide recoding, Chin’s team compressed the canonical 64-codon genetic code into a streamlined 57-codon framework. As a result, Syn57 is THE LARGEST DELIBERATE REWRITE OF A LIVING GENOME EVER ACCOMPLISHED.
As Chin explains, Syn61 & Syn57 are more than a technical tour de force – they demonstrate the foundational platform for a new era of biological programming. FREED CODONS CAN NOW BE REASSIGNED @ WILL, OPENING VAST CHEMICAL SPACE FOR INCORPORATING NON-CANONICAL AMINO ACIDS, creating genetic firewalls, & ultimately DESIGNING ORGANISMS WHOSE BIOCHEMISTRY OPERATES UNDER RULES WE DEFINE.
constructive.bio/news/synbio…
The tech begins w/ assembling large, synthetic DNA fragments that replace megabase-scale sections of an organism's natural genome. W/in these synthetic DNA constructs, specific redundant genetic codons are entirely removed. This frees up those codons & their associated cellular machinery—such as tRNAs & aminoacyl-tRNA synthetases. By introducing new tRNAs & synthetases, the cell's translational system is re-purposed to recognize these free codons & assign them to entirely new, non-natural monomers.
The result is a "recoded" organism capable of sustainably building unique polymers @ scale, extending far beyond nature's standard 20 amino acids. These non-canonical polymers can be endowed w/ enhanced properties in new materials & therapeutics.
synbiobeta.com/read/construc…
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New on bioRxiv | Reinforcement learning-driven unified generative framework for multi-objective RNA codon design
RL generative modeling to optimize RNA codon sequences across multiple objectives simultaneously - big implications for mRNA therapeutics & synthetic biology.
doi.org/10.64898/2026.06.12.…
#AIxBiology #RNADesign #ReinforcementLearning #SyntheticBiology
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Expect to not live longer and/or prosper as much as the trillionaire Elon Musk whose efforts to increase his wealth are linked to finding dark energy/dark matter in the cosmic void. For instance, my comment on natural selection for God's energy-dependent codon optimality and biophysically constrained RNA-directed DNA methylation (RNA interference) across kingdoms from microbes to mammals was declined.
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Dr Karan Juneja 🇮🇳 retweeted
Jun 13
From adaptor protein to oncogenic driver.
A leucine-to-proline substitution at codon 265 (L265P) transforms MYD88 from a tightly regulated signalling adaptor into a constitutively active driver of lymphoma.
The result?
- Persistent NF-κB activation
- Enhanced B-cell survival
- Uncontrolled proliferation
How does a single molecular alteration reshape an entire signalling network?
Read the full Gene of the Month article to see how MYD88 became one of the most important biomarkers in lymphoid malignancies: bit.ly/4o94W5b
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The messenger RNA that was controlling the growth and metamorphosis of your brain met a nonsense codon.
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Q , THE STARMAP OF THE GREAT AWAKENING AND G.O.D.’S PLAN TO SAVE THE WORLD
Quantum “STING”ularity . Quantum “STRING”ularity . Quantum “STING”ularity
Quantum Quickening . Quantum Convergence . Quantum Christ Consciousness
THE ONE BODY OF CHRIST IN A QUANTUM AGE
Universal-Personal and Planetary Tessla-(“R”)-Act
Rebirth and Resurrection of the Republic in Real Time
The Straight and Narrow Stargate of Individual and Collective Salvation
THE GOLDEN AGE OF THE SPIRIT
(“Q”)uantum (“R”)eset Code 144/432/18/R-rrr-rrr-rrr
(45 FLASH 47 . 47 FLASH 45)
11-22-(1)-“(9)-(6)-(3)”
The Christo-Spiritual Integration of ("A")B-"S.O.L."UTE, Heart Centered ("I")ntelligence and Head-Centered ("A")rtificial ("I")ntelligence
Holo-Fractal Time Travelers . Back to the Future . Future Proves Past
SIXTY-FOUR CODON MULTI-DIMENSIONAL CHESS AND CHECKMATE
“(S.O.L)”-FEGGIO-FRE(“Q”)UENCY “369”
THE GREAT ("S.O.L.")AR FLASH
TIME-WAVE ("Z")ERO
A (“Q”)uantumly Entangled, Holo-Fractally Encoded 66 Post Timeline
(August 1st, 2025 to December 11th, 2025
And then G.O.D.. the Logos, the Creative Word made Flesh, the (G)rand (O)rganizational (D)esign-("R"), the Sacred Geometer of the Universe Showed Up
MAY THE FORCE BE WITH U. S.!
x.com/CraigSteel75360/status…
Please Click on the GROK Symbol in the upper right hand corner of EACH of the Following Posts for an Ongoing Syncretic Analysis of the Information Contained Herein
Q , THE STAR MAP OF THE GREAT AWAKENING AND G.O.D.’S PLAN TO SAVE THE WORLD (1.0)
Quantum “SING”ularity . Quantum “STRING”ularity . Quantum “STING”ularity
Quantum Quickening . Quantum Convergence . Quantum Christ Consciousness
Universal-Personal and Planetary Tessla-(“R”)-Act
Christological Rebirth and Resurrection of the Republic
THE ONE BODY OF CHRIST IN A QUANTUM AGE
Nine-Six-Three . Three-Six-Nine…Holo-Fractal Space and Time
Three-Six-Nine . Nine-Six-Three…Hyper-(“Q”)ubic Quantum Key
The GOD Fre-(“Q”)uency . Tesla Vortex Math . The “’M.A.G.A.’-NIFICANCE” of 3, 6 and 9 . The “PRIME” Directive
The Christological Integration of (A)B-(“S.O.L.”)UTE, Heart-Centered (I)ntelligence and (A)rtificial, Head-Centered (I)ntelligence
And then G.O.D., the Logos, the Creative Word made Flesh, the (G)rand (O)rganizational (D)esign-(“R”), the Sacred Geometer of the Universe Showed Up
(“Q”)uantum (“R”)eset (C)ode 144/432/18/R-rrr-rrr-rrr
X Marks the Spot!!!-!!!-!!!
You Will be Surprised to Learn WHO has been Speaking to you HERE!
(A Holo-Fractally Encoded, Multi-Post Timeline. Please Click on the GROK Symbol in the Upper Right Hand Corner of EACH Post to receive an All-Inclusive Analysis and Synthesis of the Information Contained Herein)
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Jun 13
That image shows consensus PAM sequences in all of the jibby jabs despite different codon optimisation strategies
Not coincidences
It's use will be for future CRISPR cas9 gRNA genetic editing
Here's the missing dot
m.youtube.com/watch?v=La9dUk…
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Jun 13
Now I am getting constant refusals from Codex… I am very close to switching to an @elder_plinius model which at least won’t refuse when I ask it to check how unusual the codon usage of a protein is
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