MASSIVE
• 🧬 Open-source AlphaFold3 trained 10 hours on 8 A100 GPUs, no templates
• 🔄 Corrected MSA module communication step placement
• 🔀 Swapped MSA module order to match AlphaFold2
• 🔗 Added missing residual connections in DiT blocks
• ♻️ Reused OpenFold components for triangular attention
• 🔄 Repurposed MSARowAttentionWithPairBias for DiffusionTransformer
• 💾 60% operations still memory-bound
• 🧫 Training on single chain proteins
• 🔬 Extending ProteinFlow to ligands, multimers, nucleic acids
🚀Excited to announce: Open-source AlphaFold3 implementation! 🚀
I am thrilled to announce one of the models we have been building for the last 8-weeks at Ligo - an open-source implementation of DeepMind’s frontier model, AlphaFold3! Here’s what we have learned, a thread (1/11):