Does a mother's autoimmune disease affect her child's heart? New data from 1.46 million Swedish births says yes — modestly, but significantly. European Heart Journal 🧵 Maternal autoimmune disease (AID) before delivery → HR 1.19 (95% CI 1.14–1.24) for offspring cardiovascular disease in early adulthood. Key nuances: 🔬 Effect stronger for maternal vs paternal AID → suggests intrauterine mechanism, not just shared genetics 👨‍👩‍👧 Cousin comparisons attenuated but persisted → shared familial susceptibility also plays a role 🫁 Preterm birth congenital heart disease mediate ~10–15% of the association Consistent across lupus, RA, T1D, thyroiditis, vasculitis, Sjögren's, and celiac disease. Takeaway: intrauterine inflammation may leave a lasting cardiovascular imprint on offspring. #Cardiology #AutoimmuneDisease #FetalProgramming #CVD #Epidemiology

The latest work from Instituto Nacional de Perinatología Isidro espinosa de los Reyes @GobiernoMX by Dr. Anayansi Molina-Hernández and her team is now featured in JIN! Welcome to read this article 👉: imrpress.com/journal/JIN/25/… Article Highlights 💡 🧠 How might maternal hyperglycemia influence early corticogenesis in embryos without neural tube defects? Using E12 dorsal telencephalon transcriptome reanalysis, pathway-level interrogation, and multi-stage molecular and structural assessments, we examine radial migration–related signaling during early cortical development, while minimizing confounding by gross malformations. ✒ Author: Rocío Valle Bautista, Itzamara Soto-Villanueva, Dafne A. Díaz-Piña, Vivian A. Chávez Pérez, Evelin V. Idiaquez-Hernández, Daniela Ávila-González, Néstor Fabián Díaz, Anayansi Molina-Hernández 🏪 Affiliation: Instituto Nacional de Perinatología Isidro espinosa de los Reyes @GobiernoMX ; Instituto Tecnológico de Monterrey Campus Ciudad de México 📖 Don’t miss this citable reference for your future research! Citation format: Valle-Bautista, Rocío, et al. "Effect of Maternal Hyperglycemia on Cortical Neuronal Migration: Hypofunction of Reelin Signaling." Journal of Integrative Neuroscience 25.1 (2026). Welcome to submit your work via our submission link👉: imr.propub.com/ JIN welcomes original researches, reviews, short (brief) reports and other types of research contributions on molecular, cellular, systems or translational neuroscience using various approaches and functional strategies. 📑 Click here for author guidelines: imrpress.com/journal/JIN/pag… #fetaldevelopment #cerebralcortex #Reelin #signaling #fetalprogramming #maternal #hyperglycemia #diabetes #JINPaper

Pregnancy isn’t just about how much you eat, it’s about how the developing brain receives signals from the mother’s metabolism. Research shows that excessive calorie intake, especially from ultra-processed foods and high sugar, can permanently influence a baby’s brain development. Here’s what scientists have found: • Overnutrition can alter the baby’s appetite-regulation centers in the brain • It can change dopamine and reward pathways, increasing future risk of overeating • It’s linked to higher risk of obesity, insulin resistance, and metabolic disease later in life • It may affect impulse control, stress response, and emotional regulation • These changes can persist into childhood and adulthood This happens through fetal programming when the womb environment sends signals that shape how genes are expressed in the developing brain. Important context: This is not about dieting during pregnancy. Babies need nourishment but quality and balance matter more than excess. A calm nervous system, stable blood sugar, real food, and adequate nutrients send powerful protective signals to the developing brain. Pregnancy is one of the most sensitive windows of brain development. What the mother’s body experiences… the baby’s brain remembers. 📚 Sources: • Sullivan et al. (2014). Maternal obesity and neurodevelopmental programming. Trends in Endocrinology & Metabolism • Godfrey et al. (2017). Fetal programming and later health outcomes. The Lancet Diabetes & Endocrinology #CoreNeuroHealth #PregnancyHealth #BrainDevelopment #FetalProgramming #MaternalNutrition

Diabetes can begin in the womb. Yes, you read that right. Long before the first sugary snack or sedentary habit, the seeds of diabetes may already be planted, during pregnancy. 👉 Swipe to learn: ✔️ What the Barker Hypothesis really means ✔️ How fetal programming affects lifelong health ✔️ Why maternal nutrition matters more than you think ✔️ How we can prevent this cycle The good news? It's not fixed. Proper maternal nutrition, balanced pregnancy weight gain, and early-life feeding can break this cycle. #BarkerHypothesis #FetalProgramming #MaternalHealth #DiabetesPrevention #PregnancyNutrition

Dr Elena Fauste, researcher and lecturer at @USPCEU, did present an excellent poster at the @EASCongress #EASCongress2025 in Glasgow about maternal #fructose, #Westerndiet, #fetalprogramming and #Serine metabolism

Maternal #fructose induces changes in female progeny that alter their own #pregnancy, leading to #cardiachypertrophy, which is further exacerbated by subsequent fructose intake. @MDPIOpenAccess #nutrigenomics #fetalprogramming  @USPCEUprensa @Foods_MDPI mdpi.com/2304-8158/13/18/294…

#ArticlesInPress: Prenatal #stress induces sex- and tissue-specific alterations in #insulin pathway of #Wistar rats offspring Juliana Mentzinger et al ow.ly/Z3Gh50TwfHU @MiguensHelena #FetalProgramming #maternalstress #insulinresistance

📢 Join us for a seminar on OBESO Perinatal Cohort: A Platform for the Study of Fetal Programming with Dr. Guadalupe Estrada from INPer 🇲🇽. 🗓 Aug 30th, 10:30 AM (Chile) / 2:30 PM (UTC) 📍 Santiago, Chile 🇨🇱 🔗 Register here #FetalProgramming #Research #Seminar #BenthamScience

Maternal #fructose intake, via #fetalprogramming, makes a #Westerndiet far more harmful in their descendants than in the offspring from control mothers. Elevated intestinal #cholesterol metabolism and #GLP2 signaling are involved. @USPCEUprensa doi.org/10.1039/d4fo01466a

A real pleasure to participate in the interdisciplinary #esci2024 congress discussing about the fetal origin of adult disease #dohad #prenatal #fetalprogramming

Our last article at Nutrients: Maternal intake of #fructose affects #placental H2S synthesis and, interestingly, increases the risk of #preeclampsia.  #nutrigenomics #fetalprogramming @USPCEU @USPCEUprensa @CQS_Salud #mdpinutrients @Nutrients_MDPI doi.org/10.3390/nu16020309

Great field day and presentations by @WilcoxCorissa @ECornand #AlternativeMineralStrategies #MultiMin #CanolaFatCowDiets #FetalProgramming @agbiousask @SaskCanola @SaskCattlemens @LFCE_usask

Elena Fauste, researcher and lecturer at @USPCEU, presenting an excellent poster at the @EASCongress #EASCongress2023 in Mannheim (Germany) about maternal #fructose, #Westerndiet, #fetalprogramming and intestinal absortion and plasma levels of #cholesterol. @USPCEUprensa

🔓Free to Read👉Nutritional, pharmacological, and environmental programming of NAFLD in early life ( Maria-Luisa Lazo-de-la-Vega-Monroy et al.) 🖱ow.ly/Tqaq50N59fs #NAFLD #FetalProgramming #ajpgi @UdeGuanajuato

New review in #ajpgi ➡Nutritional, pharmacological, and environmental programming of #NAFLD in early life (Dax-Humberto Galvan-Martinez, et al.) 🖱ow.ly/rukt50LXKOj #ArticlesInPress #FetalProgramming #DOHaD #LiverTwitter

To know more about the "The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development" doi.org/10.3390/diabetology3… #diabetes #fetalprogramming #MitochondrialDisease #mitochondria #metabolism

The authors note the consistency of their findings with those of previous studies documenting the observability of alterable #FetalProgramming. @AshokPanigrahy6 @medrxivpreprint ow.ly/eMJF50LxYCw

Interested in developmental origins of health and disease #DoHaD #FetalProgramming #pregnancy #StemCells? Want to study in Cardiff? Funded PhD: "Aging before birth: identifying influences of modifiable maternal lifestyle on telomere length" swbio.ac.uk/ @SWBio_DTP

There are tons of studies on choline supplementation in peripartum dairy cows - but not a lot out there on the prenatal effects on calves. Check out our most recent publication in JDS. #fetalprogramming journalofdairyscience.org/ar…

#FetalProgramming may sound like something about robot infants, but it's actually a detailed theory of how we develop before we're born. Learn more about how a fetus' environment affects the person it grows into: bit.ly/3x3Yfbm #DevBio Image by drsuparna via Wikimedia