grabbing a quick bite🍛while hopping in btw nonstop #frozensection🔬cases

#Compassion and #precision is corner-store of #surgicalpathology . Many life altering diagnosis handed out to patients start from our desk #GYNpath #PathTwitter #pathx One such old case always humbles me! Routine #frozensection for enlarged ovary, found on annual checkup.

❄️ Frozen to Final: Diagnostic Correlation Case: 75M with massive compressive thyroid mass (9 cm) with tracheal invasion 🧊 Frozen: Malignant tumor (subtype deferred) 💎 Final diagnosis: Medullary Thyroid Carcinoma 🔬 Key features: • Nests, trabeculae, cords • Polygonal cells, granular cytoplasm • Salt & pepper chromatin • Lymphovascular invasion 🧪 IHC: Calcitonin , CEA , Synapto , Chromogranin , INSM1 CK7 , CK20-, TTF1 (diffuse) Thyroglobulin–, PAX8–   🧬 Molecular: • Activating RET mutations in majority (germline in hereditary cases – MEN2A/MEN2B; somatic in sporadic) • RAS mutations (HRAS/KRAS) in RET–negative tumors • Routine: recommend RET mutation testing ± germline screening (important for family counseling)   📊 Prognosis: • Variable; worse with: Older age, large tumor, extrathyroidal extension (like tracheal invasion here) and distant metastasis • 10-year survival ~70–80% overall, but ↓ significantly in advanced disease • Calcitonin doubling time = key prognostic marker   💡 Pearl: When morphology & clinical picture mismatch on frozen → call “malignant” & defer typing. IHC serum calcitonin clinches MTC. #PathTwitter #Surgpath #EndocrinePath #ThyroidPath #MedullaryThyroidCarcinoma #FrozenSection #Histopathology #Pathology Case courtesy @annsmiley78

❄️ FROZEN SECTION. 👉 75 YO male with massive thyroid mass (9 × 6 cm) replacing the left lobe, with tracheal invasion and loss of fat plane with esophagus. Intraoperative frozen section performed. Diagnosis? #PathTwitter #SurgPath #ThyroidPath #FrozenSection #DiagnosticDilemma #Histopathology #OncPath #MedEd Case courtesy @annsmiley78

Frozen section challenge: • 2-cm well-circumscribed tan thyroid nodule • Diff-Quik: plasmacytoid cells in a bloody background What’s your diagnosis at the #FrozenSection bench? IHC result below 👇 #cytopath #thyroidpath #pathology

At frozen section, what do you do with tumorlets at a parenchymal margin in a resection for carcinoid tumor? The best approach is to discuss with the surgeon. #lungpath #frozensection #pathology #thoracicpath

uncommon #ENTpath #frozensection I had a while back: prior thyroid FNA called susp for PTC central neck LN submitted for🥶frozen🔬

2025 Frozen Sectioning Competition – Hangzhou Showcase📹 This is a video of the sectioning operation performed by the winning participants in the 2025 Third National Frozen Sectioning Competition (Hangzhou) Selection Round. In recent years, RWD sectioning machines have consistently supported national and provincial sectioning competitions. In 2025, as of now, RWD has accompanied the frozen/paraffin sectioning competitions through Shanghai, Jining, Fuzhou, and Hangzhou. RWD's frozen sectioning machines offer precise temperature control, providing a strong guarantee for the production of high-quality sections, and have earned praise from both experts and participants on-site. We thank all our partners who have supported RWD along the way, and we also hope to gain the trust and recognition of more customers. Therefore, we have prepared a free demo for you who are watching this video. If you are interested, please click the link to contact us. bitl.to/4tha For more information：rwdstco.com/ #cryostat #cryostatmachine #cryostatinhistopathology #cryostatprice #frozensectioncryostat #cryosectionmachine #cryostatmachineprice #cryostatcost #cryostatmicrotome #frozensectionmachine #frozensection #frozensectioninhistopathology

Thyroid vs parathyroid on frozen section?? Just flip that condenser and look for CALCIUM OXALATE crystals! - seen in colloid - can help make this distinction when present. #pathX #frozensection #pathology ❄️

Common #frozensection in #GUpath. I never get tired of this classic 🐯 background of touch preps from this testicular tumor. What's your diagnosis, #PathTwitter? Answer & more info in the comments 👇🏻

A lesson in how important clinical information is for accurate pathological diagnosis 🔬 #Frozensection from the large bowel wall of a young female. What's your diagnosis #PathTwitter?

Gross radiological correlation, frozen section #frozensection #grossognosis #pathology #Histopath #grosspath

Touch prep at #FrozenSection, testicular tumor. What's your diagnosis? 🔬 #CytoPath #GUPath #PathTwitter

#GUPath frozen section of a renal mass. What's your diagnosis? 🔬 #PathTwitter #FrozenSection #pathresidents #pathfellows

Frozen section of a 20 cm ovarian mass, extensively necrotic cut surface with a rim of viable, solid-white tissue. What's your diagnosis? #PathTwitter #frozensection #gynpath

Intraoperative pathology consultation is a cornerstone of excellent patient care; Gary Keeney and John Cheville partner with clinical and industry leaders to design the future of frozen section pathology at Mayo Clinic. #pathology #digitalpathology #ai #frozensection #mayoclinic

when you show off your #frozensection skills & cut a really long ribbon section on the cryostat

PMHx of "parathyroid carcinoma" status post parathyroidectomy & radical neck dissection → 3 years later shows multiple, non-infiltrative nodules of benign parathyroid Final dx: parathyromatosis, local recurrence due to mechanical displacement of benign hyperplasia. A solitary nodule & serum Ca²⁺ > 14 favor carcinoma #frozensection #endopath #pathresidents #pathtwitter #entpath ✅Benign

Neck mass & hyperparathyroidism (Ca²⁺ 12 mg/dL) refractory to parathyroidectomy, benign or malignant? #frozensection #endopath #pathresidents #pathtwitter #entpath 🔬virtualpathology.leeds.ac.uk…

#Frozensection on D&C from suspected ectopic pregnancy is HARD. Missing implantation site can mean undercalling intrauterine pregnancy. When you don't see villi or implantation on the frozen do you sign out as: #OBpath