It was an honor to highlight this fantastic work by Cheng and Venkatesh et al of the Gordon lab @gordonlab. Many thanks to them, and to Francis Chandra for doing all the heavy lifting on this Spotlight!
🔦Spotlight of article by Jeffrey Gordon and colleagues in @ScienceMagazine: FAAHcilitating Recovery in Malnourished Kids by Franciscus Chandra and Elaine Hsiao @pipethero at @UCLAdlvr.it/TGv3Rn
Today we report in @NatureBiotech twin prime editing to make larger substitutions, insertions, & deletions. TwinPE recombinases can make gene-sized (thousands of bases) precise insertions & inversions at sites of our choosing in human cells. Tweetorial👇🏼drive.google.com/file/d/1GQL…
Used the concept of 'ecogroups' to characterize states of malnutrition in children (Science, 2019).Framework for directed evolution of microbiota. Fecal sample -> gavage -> preclinical models -> mutagenesis selection move microbiome in a maximal gradient method #KSmicrobiome
Fantastic talk by Arjun Raman!(@gordonlab )To think of the microbiome in a collective form at the scale of ecosystems instead of a parts list.Behavior emerges from sets of localized interactions. Identified "ecogroup" of 15 collectively varying group of microbiomes #KSmicrobiome
Researchers have designed a #diet that can help digestive tracts damaged by acute childhood malnutrition develop a mature #gut microbial community, necessary for proper growth and functioning. Read the study in Science: fcld.ly/m5e1pnn