Hey hypath! This issue is still being worked on, and you can keep an eye on the progress here: trello.com/c/Tgpn1jCO. We appreciate your patience, and thank you for the report! 🙏
Hypath Travel is giving me one of their new 8-in-1 Transformer Travel Backpacks to give away to my audience for free!
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Synovial sarcomas most often present in a young adult with a mass near a large joint on an extremity. Despite the name, it does not actually arise from the synovial surface.
(PS: I totally used my handy dandy templates to make this. You could too!)
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Retweeting this for studying purposes. Just because a stain is "brown", doesn't always mean it is positive! It's important to keep that tidbit in mind.
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I'll be giving a talk on IHC panels & pitfalls at the end of the month. Did you know that S100, calretinin, and beta-catenin are supposed to have both nuclear AND cytoplasmic staining in order to call it "positive"?
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Some histologic subtypes tend to be more high grade. Patients with Rb mutation are at 500x inc risk of developing osteosarcoma
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OSTEOSARCOMAS- Malignant bone-forming tumors of osteoblasts. Most patients are younger & present with pain or swelling around the knee. HY imaging = "Codman's triangle".
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#4- Myxoid chondrosarcs have prominent myxoid component. HY association = translocation t(9;22) in extra-skeletal myxoid CS (CHN-EWS gene fusion)
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#1- Chondrosarcs are often resistant to chemo/rad. Conventional CS is the most common type of CS; tends to occur in older males in the MEDULLA of proximal bones (pelvis & shoulder girdles).
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PATH TWEETORIAL 1/6:
To continue on with cartilaginous tumors of the bone- CHONDROSARCOMA (CS). 2nd most common malignant bone tumor. Large, infiltrative tumors in the central skeleton/pelvis/shoulder girdle/prox long bones of older pts.
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I go through spurts of reading (absent from SoMe) followed by creating & sharing. Here are a few of my compilations... HY summaries of benign cartilaginous bone tumors.
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Thank you all again so much for your generous donation to the #PathTweetAward. As a token of my appreciation, here are some behind the scene views of what I've been working on... I pinky promise I will be updating my website with lots of goodies soon! #PathTweetAward#HYPath
Inflammatory Fibroid Polyps- most common in the gastric antrum in older women. Bland spindled cell lesion with inc eosinophils, variably sized blood vessels and edematous, myxoid background. Centered in submucosa. PDGFR mutation.
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