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1/ Does awake proning improve outcomes in patients hospitalized with #COVID19 and hypoxemia who don’t require intubation? This clever study has persuaded me: probably not. #HowIReadThisPaper jamanetwork.com/journals/jam… (Thread)

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1/ Should we use #remdesivir (RDV) to treat high-risk outpatients with #SARSCoV2 #COVID19? Here's #HowIReadThisPaper on the PINETREE trial by Gottleib et al in @NEJM (Thread) nejm.org/doi/full/10.1056/NE…

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1/11 What is the global burden of bacterial antimicrobial resistance? Here’s #HowIReadThisPaper on antimicrobial resistance in 2019: a systemic analysis. Murray et al, published 19.1.22: thelancet.com/journals/lance… @MedicsAcademy

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1/ Should we use #molnupiravir (MOV) to treat #SARSCoV2 #COVID19? With new @NIH treatment guidelines out, it's time to review the evidence behind them. Here's #HowIReadThisPaper on the MOVe-OUT trial by Bernal et al in @NEJM (Thread) nejm.org/doi/full/10.1056/NE…

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1/ #COVID19 increases perioperative mortality. But how long after diagnosis should we delay a needed surgery? Here’s #HowIReadThisPaper on the COVIDSurg Collaborative study published in @Anaes_Journal: associationofanaesthetists-p… (Thread)

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10 Jan 2021
1/ Does #Remdesevir have a role in #COVID19? Here is a short #HowIReadThisPaper Tweetorial on a study recently published to try and answer the question. Beigel, J et al (ncbi.nlm.nih.gov/pmc/article…) @MedicsAcedemy By @amyprid
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1/ My appraisal of the Danish mask study (DANMASK-19): This was a negative trial - masks were not shown to prevent #COVID19. Could chance or bias make this outcome more likely? Does this mean we don’t need to wear masks? Let’s take a deeper look. #HowIReadThisPaper (Thread)
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1/ #SARSCoV2 #COVID19 got you down? Me too. Ready for some good news? Here it is: #Dexamethasone (dex) works. But when, how much, and for which patients? Here’s #HowIReadThisPaper on Horby et al: the RECOVERY trial prelim report: nejm.org/doi/full/10.1056/NE… (Thread)
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1/ My appraisal of the RECOVERY trial: This was a (very) positive study. How could chance or bias affect the validity of these results? What was missing? How should we apply these results? Let’s take a deeper look. #HowIReadThisPaper
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1/ If we knew nothing about systemic racism in the US, would we still find evidence of it in the impact of #COVID19 #SARSCoV2 on Black Americans? Let’s take a look. Here’s #HowIReadThisPaper on the @NEJM special article by Price-Haywood et al: nejm.org/doi/full/10.1056/NE… (Thread)
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1/ A #MedTweetorial on #HowIReadThisPaper for #DISCOVERYtrial - dex edition on @medrxivpreprint. We’ll be exploring the pre-print, supplement, and trial document. Would love for feedback, thoughts, & comments! Currently, what is your opinion on using dexamethasone?
0% Treat nobody yet
74% O2 needed vent
14% Vent only
12% Waiting on paper
117 votes • Final results
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1/ How common is loss of smell (anosmia) in #SARSCoV2 #COVID19, and how useful is it for ruling the diagnosis in or out? Let’s take a look at the data. Here’s a quick #HowIReadThisPaper on two @AnnalsofEM papers addressing this question: Chua et al & Peyroney et al (Thread)
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Replying to @TheLancet
looking forward to reading dr @rbganatra and @IDJClub's take on #HowIReadThisPaper #medtwitter
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1/ Should we use #Lopinavir-ritonavir (LPV/r) #Ribavirin (RBV) /- #Interferon beta-1b (IFN) to treat #SARSCoV2 #COVID19? Let’s take a look at the data. Here’s: #HowIReadThisPaper on @TheLancet trial of triple therapy for COVID19 Hung et al: thelancet.com/journals/lance…
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1/ Should we use #Remdesivir (RDV) to treat #SARSCoV2? #COVID19 Let’s take a look at the data. Here’s: #HowIReadThisPaper on the @Lancet trial of RDV for COVID19 in humans Wang et al: thelancet.com/journals/lance… (Thread)
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1/ Should we use #Remdesivir (RDV) to treat #SARSCoV2? #COVID19 Let’s take a look at the data. Here’s: #HowIReadThisPaper on the @Lancet trial of RDV for COVID19 in humans Wang et al: thelancet.com/journals/lance… (Thread)
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1/ What is the risk of macrovascular thrombosis among critically ill patients with #SARSCoV2 #COVID19? Let’s take a look at the data. Here’s #HowIReadThisPaper on a @ThromboisRese1 case series examining this question: Klok et al: thrombosisresearch.com/artic… (Thread)
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