Our latest study examines the heterogeneity of immune checkpoint expression in cancer and its relationship to dysregulated tumor metabolism. While PD-1/PD-L1 blockade, such as pembrolizumab, has demonstrated significant efficacy in melanoma and certain hematologic cancers, its impact in most solid tumors remains limited. We propose that this disparity is driven by immune checkpoint heterogeneity, where multiple inhibitory pathways beyond PD-L1 are co-expressed and may exert equal or greater suppression of cytotoxic T cell function. This layered inhibitory landscape, potentially reinforced by tumor metabolic reprogramming through lactate, may explain the limited responsiveness of many solid tumors to single-agent PD-1/PD-L1 blockade. 👇 biorxiv.org/content/10.64898… #cancermetabolism #immunoncology #lactate #immunecheckpoints

A new Science #Immunology Review discusses the nuances of #cancer immunotherapies that target inhibitory #ImmuneCheckpoints and examines avenues for improved strategies and outcomes. @VeilletteAndre scim.ag/4myNhBy

IFI-JLM Scientific Session!! 📅 Date: June 25th 📷 Featured Topics: #Immunecheckpoints #SolidCancer 🎤 Key Presenter: Jiabi Zhang (@Miazhang0116) from @xingxing_zang Lab!! @EinsteinPhD @ae_cancercenter @EinsteinMSTP @EinsteinMed @MontefioreNYC

x.com/MeasslainteIRL/status/… 🧬 How Viruses and Tumors Hide — and How to Unmask Them Cancer cells and viruses cloak themselves using immune checkpoint tricks: ⬆️ PD-L1 expression (shuts off T-cells) 🧬 IgG4 shift (immune tolerance mode) But nature gave us compounds to strip the disguise 👇 🟢 Apigenin (Chamomile, parsley) • Blocks PD-L1 via STAT1 inhibition • Frees T-cells to attack 📖 Xu et al., 2018 🟡 Berberine (Goldenseal, Coptis) • Reduces PD-L1 by inhibiting CSN5 deubiquitinase • Boosts CD8⁺ T-cell infiltration 📖 Zhang et al., 2020 🔵 Quercetin & Kaempferol (Red onion, apples, leafy greens) • Directly block PD-1/PD-L1 binding • Best binding strength among dietary flavonoids 📖 Guo et al., 2024 🍄 Reishi & Turkey Tail Mushrooms • Increase NK/T-cell activity • Promote anti-tumor immunity and correct Treg/Th17 balance 📚 Immune-balancing adaptogens for checkpoint synergy 🔬 Stack With Your Existing Protocol Your base p53 protocol includes: ✅ Ellagic acid (pomegranate) → p53 activation, apoptosis ✅ Baicalin (skullcap) → boosts p53 expression ✅ Quercetin Zinc → stabilize p53, reduce oxidative damage Now you’re layering in: 🎯 Checkpoint Blockade • Apigenin → STAT1 ⛔ • Berberine → CSN5 ⛔ • Quercetin/Kaempferol → PD-L1 direct binders 🧠 Result? • Cancer can't hide • p53 gets restored • Immune system gets unleashed • Apoptosis DNA repair immune surveillance = full-spectrum protection 🛡️ A Holistic Cancer Defense Framework LayerKey Compounds 🔬 p53 ReactivationEllagic Acid, Baicalin, Zinc ⚡ Stress ReductionQuercetin, Zinc 🎯 Immune Checkpoint BlockApigenin, Berberine, Quercetin, Kaempferol 🍄 Microenvironment BalanceReishi, Turkey Tail 🔗 References: 📌 Apigenin & STAT1/PD-L1 Blockade jeccr.biomedcentral.com/coun… 📌 Berberine Targets CSN5 & Reduces PD-L1 sciencedirect.com/science/ar… 📌 Flavonols Block PD-1/PD-L1 Binding (Quercetin, Kaempferol) pubs.rsc.org/en/content/arti… 📌 Apigenin Boosts T-cell Activation (2017 Study) sciencedirect.com/science/ar… Nature isn’t just gentle it’s tactical. Support your genome. Free your immune system. Start with food. Stay with science. #p53 #ImmuneCheckpoints #PDL1 #Apigenin #Berberine #Quercetin #Kaempferol #Reishi #CancerPrevention #FunctionalMedicine #TumorMicroenvironment #NaturalHealing #Immunotherapy #NutritionIsMedicine

PD-L1 & IgG4 Immune Escape 🦠 Viruses & tumors cloak themselves by raising PD-L1 and shifting to IgG4. 🛡️ Strip the cloak with: Apigenin herbs (chamomile, parsley) Berberine (Th1/Th17 support) Reishi, Turkey Tail (mushrooms FTW) #ImmuneCheckpoints

#MACE #ImmuneCheckpoints

Congratulations and thank you @PhoebeTsou!!! Nice paper, and also the 1st official from my lab 🎉 Thank you @MichaelHenegha8, Yooyun Chung, and Shilpa (@ChokshiLab @HepatoPlymouth), for your support with this work! #LiverTwitter #Cirrhosis #ImmuneCheckpoints #PBC #Interferon

Huge congratulations to Dr. @MC_Pulanco on successfully defending your #PhD on new #ImmuneCheckpoints in #BladderCancer!! Wishing you all the best for your future endeavors!! @EinsteinPhD @ae_cancercenter @EinsteinMSTP @EinsteinMed @MontefioreNYC

Recently published: Spatial context of #immunecheckpoints as predictors of overall survival in patients with resectable #colorectalcancer independent of standard TNM stages, by Hao Kong et al. doi.org/10.1158/2767-9764.CR… @jiangh7 #ImmuneCheckpointBlockade #openaccess

1. #Neuropilin-1 on #CD8 T-cells is newest member of #immunecheckpoints joining #CTLA4 #LAG3 #PD1 #TIM3. #NRP1 expression increases w/ other T-cell exhaustion markers and impairs T-cell migration to tumor. nature.com/articles/s41467-0…

🚨#ICYMI ➡️ The latest issue of ImmunoHorizons #ReadIH #OpenAccess is available online! #NewInIH #Immunology #infection #vaccination #CARTcells #EpitopeDiscovery #ImmuneCheckpoints & so much more - Take a look: ow.ly/Jzsi50SPzBE

🚨#ICYMI ➡️ Check out the latest issue of ImmunoHorizons #ReadIH #OpenAccess #NewInIH - Available online! #Immunology #infection #vaccination #CARTcells #EpitopeDiscovery #ImmuneCheckpoints & so much more! journals.aai.org/immunohoriz…

Fantastic talk of our PhD student Spyridoula Barmpoutsi in the Lung cancer macrophage #immunecheckpoints at #DZL2024 as early career scientist highlight! @SBarboutsi @r_savai @PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #Microenvironment 🫁🧬🔬

Beyond proud of our PhD candidate Ramsha Masood from vonfeldenlab.com to present our study on #extracelullarvesicles #EV #immunecheckpoints in #LiverCancer #EASLcongress @EASLedu @EASLnews

#Tumormicroenvironment #macrophages #Notch #immunotherapy #immunecheckpoints 🔥Review: Signaling and molecular networks related to development and inflammation involved in CCA initiation and progression 👉Download PDF: f.oaes.cc/xmlpdf/af055ec7-68…

ICI myocarditis made easy by Alex Lyon from the @RBandH. #cardiooncology #cardiotoxicity #immunecheckpoints #myocarditis

These weeks our group is joining forces to deepen on the role of immunecheckpoints along PRRSV-1 infection. Thanks to Enric Mateu lab for all your collaboration!! Let's keep going!!💪🏼🐖🦠 @VeterinariaUCO @Univcordoba @ENZOEM_UCO

Cardio-Oncology Summit with a view! @nanapoku602 @sohaibnazir @MurphyTheodore @drtarsh #cardioonc #immunecheckpoints #cancerandheart

#LatestPaper 📢"Immune Checkpoints in Solid Organ Transplantation" ✍️by Arnaud Del Bello and Emmanuel Treiner 👉mdpi.com/2530920# #immunecheckpoints; #tolerance; #immunotherapy #openaccess #article#CallForReadin

#EACR2023 is in full swing! Today, Eva presents poster: "Multiplexed proximity ligation-based method uncovers immune checkpoint activation in the context of the tumor microenvironment" in #immunotherapy (topic #Immunecheckpoints). Digital copy here: navinci.se/eacr2023/