External validation of nomograms for predicting lymph node invasion (LNI) in prostate cancer patients with negative PSMA PET-CT. What did we find? The Briganti 2023 nomogram is the most accurate! 📊✅
🔍 Why does it matter?
Extended pelvic lymph node dissection (ePLND) is the gold standard for staging but comes with risks. With PSMA PET-CT revolutionizing imaging, we need better predictive tools to avoid unnecessary procedures.
📌 Key Findings:
•Among 282 patients, 13% had LNI despite negative PSMA PET-CT.
•The Briganti 2023 nomogram outperformed others (C-index: 77% vs. MSKCC 64%, Briganti 2017 69%, Amsterdam-Brisbane-Sydney 64%).
•Using a 5% risk cutoff would spare 47% of ePLND procedures while missing only 3.8% of LNI cases! 🚫🔬
⚖️ Clinical Impact:
•Improves decision-making: More precise risk stratification means fewer unnecessary surgeries.
•Saves patients from complications: ePLND has side effects; avoiding it when possible is crucial.
•Guides personalized treatment: Selecting the right patients for ePLND enhances care quality.
👨⚕️ Takeaway: The Briganti 2023 nomogram should be the go-to tool for predicting LNI in prostate cancer patients with negative PSMA PET-CT! 📈
🔗 Read the full study here:
sciencedirect.com/science/ar…
#ProstateCancer #Urology #PSMAPET #LymphNodeDissection #Nomogram