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In-hospital initiation of SGLT2 inhibitors in acute heart failure shows consistent benefit across RCTs (n=4,096; 8 trials) Systemic review and metanalysis.
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Curcumin in arthritis may have NSAID like clinical efficacy. But how? Metanalysis lays out the multiple potential effects for it to inhibit inflammatory signaling pathways (NF-κB, TNF-α, IL-1β, IL-6, COX-2, and PGE2) buff.ly/H5KkVIi
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The infamous failure of a spell check. I’d like to thank @JLCederblom for providing me this event. My explanation of the situation will be brief as he grilled the paper himself. Here’s a link to his input, which I will summarize below the link. medium.com/@JLCederblom/at-w… A paper called Plastic and Reconstructive Surgery Global Open was published in 2021. It was part of a set of 4 projects reviewing regret rates of trans procedures and costed thousands of dollars to produce. pmc.ncbi.nlm.nih.gov/article… It calculates the percentage of trans people in the U.S. to be .6% based off of a study in 2014, which is a whopping 7 years prior to the report. I cannot believe for the life of me that this was a convenient or satisfactory way of producing a population estimate. By 2021 transgenderism was mainstream and widely pursued academically, so a quick google search would surely provide a modern population at the top of the search results. The study failed a spell check at the time. That isn’t a small error on launch. I say here and there that many practices in this field should get someone fired but this should get someone banned from touching the practice ever again. For reference there were 9 authors. When confronted they were defensive. They refused to listen to any criticism they received and the project remained on the national library of medicine as kind of a wall of shame decoration. Here are some funny grammar mistakes from the study they died on the hill for: “transfemenine” (this misspelling was constant) “gender non-confirming” (I guess they can’t confirm nor deny their gender?) “metanalysis” (also constant “discriminating the prevalence” (???) There’s more. It’s a funny read. Despite this and despite fucking yo every part of the study, it’s been sited 235 times and is widely utilized in debates. Pro-trans debaters will never cease to embarrass themselves. As funny as this is, I must express with sincerity that this is an egregious practice. To release a study this bad and dying on the hill they have spread extremely dangerous misinformation that continues to harm children.
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🔥Further #data on 🫀 #benefits of GLP1RA & SGLT2i , a #metanalysis by 🏥 #SanFilippoNeri cardiology led by Prof Furio Colivicchi ✍️Gaetano Marino Alessandro Alonzo Vito Altamura 👉 karger.com/crd/article-abstr… @CardioKarger
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Replying to @SVRaoMD
on the bright side at least it's not yet another registry/NIS/etc analysis or the metanalysis number ten thousand on some topic
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🚨 LIVE from AUA – @marcojruro is presenting metanalysis of BPH treatment.Congrats to this outstanding urology candidate-soon to be Research Fellow in Cincinnati and future Urology Resident! Proud to support the next generation of innovators. #AUA2026 #Urology #BPH #Endourology
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Replying to @drterrysimpson
Your first metanalysis cited (Donnon) which attempts to find a correlation between mcat and performance in medical school is pretty poor at answering the question of URM performance once in medical school. Most of the papers don't have demographic data. In the three papers where URM is defined, one of the papers defined URM as Asian/Pacific Islanders in Hawaii. There also isn't a very good metric of med school performance.. shld we use Step 1 scores ? (that's what donnon used as one metric of performance). One marker of performance in medical school that's easier to look at is attrition rate. Since there is this significant range of standardized test scares that breaks down by race thanks to folks like you sitting on medical school admissions committees, it would be interesting to see 1. What is the attrition rate by race and 2. Does standardized test scores affect the attrition rate. Nguyen et. al looked at this in a pretty large sample and finds that the attrition rate for URM groups is 2-5x the white group. Interestingly, 3000 students don't report their race -- this group has the lowest attrition rate (even those self reporting as white). Adjusting for MCAT score shrinks the attrition rate disparity by almost half, though it doesn't abolish it. The MCAT ranges are in quartiles which is a sig. limitation at the lower ends.. an MCAT of 21 is very different than an MCAT of 27 , but for the purpose of this analysis would be in the same quartile mcat bucket. But regardless, shrinking the attrition rate by half is a pretty big number ! So I can see why most universities who would love to lower attrition rates can't get rid of standardized tests as much as they would like to. The authors of this attrition paper come to the interesting conclusion that because adjusting for MCAT doesn't completely take away the attrition rate disparity, this means attrition is unlikely related to academic unpreparedness. I think the more objective/honest framing would be : "MCAT explains a significant portion of the disparity, and the residual gap may reflect other factors including additional academic preparation differences not captured by quartile-level MCAT adjustment, or genuine institutional/discrimination effects, or some combination." With regards to the institutional discrimination possibility towards non-white students creating high attrition, there seems to be little interest in the fact that Asian students are 18.2% of the sample, larger than all URM groups combined, and their attrition (2.4%) is statistically indistinguishable from white (2.3%). Whatever explains the URM-white attrition gap, it doesn't seem to be generic "minority status" or generic "discrimination against non-white students." The white male patriarchy narrative also doesn't make a whole lot of sense when you see what's happened to white males in medical school. White males have gone from being the only kind of medical student to 31% of all medical students in 2014, and 20% of all medical students in 2025. The data makes clear an admissions process that involves lower MCAT thresholds for URM applicants are not a costless transfer. They produce a population of admitted students with substantially higher attrition rates. The students themselves bear most of this cost in the form of debt, lost years, lost opportunity, psychological damage of dismissal. A more productive discussion would be to arrive at some other proxy for medical school admission rather than race -- perhaps participation in varsity sports should count a lot more than it already does, or maybe performance in carpentry to get a better feel for how good someone's hands are. And even if we were to take as a given that the patient physician racial concordance outcome data isn't terrible (it is extremely low quality to base civil rights violating policy on), the downstream effects of this are what exactly -- does this mean indian origin folks like me can only practice in places like Edison, NJ (I like Edison!), should URMs be restricted in their practice location to certain zipcodes? Should physician groups target certain providers for certain patients ? None of this makes a terrible amount of sense.
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Urology resident candidate, @nathanjoseph_sg presenting his metanalysis on outcomes of Minimally invasive treatment for BPH. @AmerUrological @UTHealthHouston @sbuoficial
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Replying to @marcsh @mykola
That study/metanalysis is the entire reason I got diagnosed and medicated. Genuinely lifechanging. And i did have to get a neuroeval to make sure it wasn’t early onset dementia, etc!
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Replying to @aakashgupta
Dumbest take in X today. Congrats. “bUt a MeTaNaLySiS sHoWeD!”🙄
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Replying to @JungeToerless
People into neo-Comtean positivist sociology simply don't have a structured worldview w/ any kind of conceptual unity at all whatsoever. If some study or metanalysis comes out which suggests (but doesn't prove/demonstrate) something, they blindly change their mind w/o knowing why
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This metanalysis says no they don't
studies have shown things about stuff
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RA is significantly associated with an increased risk of osteoporotic fractures (OPF) -RR 1.47 (1.32–1.64), for both female (1.39) & male(1.69) pts. Metanalysis of OPF in RA (7 cohort studies, 12,408pts). buff.ly/1CUXm7Y
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Comprehensive, objective and accurate - metanalysis & holistic recommendation by Mr. Kienge 👇 circumnavigating $AVZ situation. Thank You, @KiengeKki 🙏
#Lithium_Manono🇨🇩 : à $AVZ🇦🇺, #KoBold🇺🇸, #CATL🇨🇳 et #RDC Kiki #Kienge analyse Le dossier du lithium de Manono, en RDC, est un des théâtres les plus révélateurs de la nouvelle guerre économique mondiale. À travers l’opposition entre KoBold Metals et AVZ Minerals, et en toile de fond l’intérêt d’acteurs chinois comme CATL, se joue bien plus qu’un simple litige minier : c’est l’accès aux ressources critiques du XXIe siècle qui est en question. Une lecture attentive des dynamiques en cours permet de dépasser les positions de principe pour comprendre les véritables rapports de force. D’abord, il est probable que KoBold cherche à acquérir les actifs d’AVZ dans des conditions favorables. Ce type de stratégie est classique dans l’industrie extractive : les actifs juridiquement fragilisés ou politiquement contestés sont souvent rachetés avec une décote significative. Mais réduire cette approche à une tentative d’achat “à prix dérisoire” serait excessif. Le gisement de Manono est tout simplement trop stratégique pour être bradé. Même en situation de conflit, sa valeur reste considérable, à la fois sur le plan industriel et géopolitique. Ensuite, la rivalité entre acteurs américains et chinois structure profondément ce dossier. La Chine, forte d’une présence ancienne en Afrique et d’un contrôle avancé des chaînes de valeur des batteries, dispose d’un avantage réel. Ses entreprises, à l’image de CATL, bénéficient d’un soutien étatique, d’une capacité d’investissement rapide et d’une tolérance au risque plus élevée. À l’inverse, les acteurs occidentaux, bien que puissants technologiquement, évoluent dans des cadres juridiques et politiques plus contraints. Cela alimente une hypothèse crédible : celle d’une surenchère chinoise. Pékin pourrait proposer des conditions financières plus attractives à la fois pour AVZ et pour les autorités congolaises. Dans un contexte de pression économique, une telle offre serait difficile à ignorer à Kinshasa. Toutefois, réduire l’issue du dossier à une simple question de montant serait une erreur. Les arbitrages juridiques internationaux, les équilibres diplomatiques et les considérations de souveraineté jouent un rôle tout aussi déterminant. Dans ce jeu complexe, la position de la RDC est centrale et décisive. Le pays dispose d’un levier exceptionnel, mais aussi d’une responsabilité majeure. Sa crédibilité internationale est en jeu. Les incertitudes juridiques, les conflits d’attribution et les soupçons de gouvernance fragilisent son attractivité auprès des investisseurs. La réforme d’entités comme COMINIERE, la transparence dans la gestion des licences et la clarification des rôles institutionnels doivent être une priorité pour le gouvernement congolais. Notre analyse va en profondeur des facteurs politiques internes. À l’approche d’échéances électorales majeures en 2028, chaque décision stratégique devient plus sensible. Les autorités de Kinshasa peuvent être tentées de renégocier, de temporiser ou de reconfigurer les alliances. Pour les investisseurs, comprendre ce calendrier est essentiel. Le temps politique congolais n’est pas un paramètre secondaire : il structure l’ensemble du dossier. Au fond, Manono n’est pas seulement un projet minier. C’est un test. Un test pour la capacité de la RDC à affirmer sa souveraineté tout en restant crédible. Un test pour les États-Unis et leurs alliés, qui cherchent à sécuriser des ressources critiques face à la Chine. Un test, enfin, pour la COMINIERE à savoir naviguer dans un environnement où la géopolitique compte autant que la géologie. Conseil de Kienge : - aux acteurs américains, et en particulier à KoBold Metals, il est essentiel de comprendre que le facteur temps est déterminant. L’horizon politique de 2028 pèsera lourdement sur les décisions à Kinshasa. Lire correctement ce calendrier, anticiper les inflexions du pouvoir et agir au bon moment sera au moins aussi décisif que la solidité financière du projet. - à AVZ Minerals, le choix des partenaires doit rester guidé par une seule boussole : l’intérêt des actionnaires. Qu’ils soient chinois ou américains, les repreneurs potentiels doivent être évalués à l’aune de leur capacité à préserver la valeur, sécuriser les actifs et offrir une issue crédible à un dossier devenu hautement incertain. - au pouvoir de Kinshasa, l’enjeu dépasse largement Manono. Il s’agit de restaurer la confiance. Cela passe par un assainissement réel des structures, à commencer par COMINIERE, qui doit devenir une entité crédible et transparente. Cela suppose également de réduire l’influence des réseaux corruptibles, de renforcer les institutions techniques, notamment le ministère des Mines et celui du Portefeuille et de redonner un rôle effectif aux autorités locales du Tanganyika, au plus près des réalités du terrain et des intérêts de la population locale. @KoBold_Metals @MinMinesRDC @LouisWKabamba @portefeuille_cd @Presidence_RDC @ChrisKitungwa @AvzMinerals @USAauCongo @US_SrAdvisorAF
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Malignancies Not Increased with Biologic Therapies The risk of malignancy in RA patients receiving biologic agents was evaluated by metanalysis of RCTs and found no significant increased risk of malignancy compared with other DMARDs or with placebo. buff.ly/jawPFGK
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Malignancies Not Increased with Biologic Therapies The risk of malignancy in RA patients receiving biologic agents was evaluated by metanalysis of RCTs and found no significant increased risk of malignancy compared with other DMARDs or with placebo. buff.ly/jFIfaTV
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Replying to @mathillustrated
That is to say: we've run experiments, taken tests, collected data & surveys, made complex statistical analysis, run metanalysis, and we have arrived to this conclusion: one way or another this makes that increase and that makes this increase. I'm astonished. True science.

ALT Im Sorry Jason Orlean GIF

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