11 Apr 2024
Worried about Ni over-arylating your dichloro(het)arenes?🫨🤔 Check out our recent work exploring selective monoarylation, in collaboration with @NeufeldtLab and @CortevaUS #ProcessChem
Congrats to @geraldoduran96 and team!🥳🎉
pubs.acs.org/doi/full/10.102…
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13 Feb 2024
"Solving an emulsion presents challenges, with viscosity playing a crucial role, increasing the temperature of the biphasic system and diluting the phases can enhance coalescence and phase separation." #processchem #realtimechem
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12 Feb 2024
Engaging in daily sketching of reaction apparatus can enhance focus, observational skills, and attention to details. Here's a depiction of a 500 ml apparatus. #chemtwitter #realtimechem #processchem #sketching
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15 Jun 2023
The best method would be to precharge the catalyst and dose the malonic acid into hot solvent. Also a good example of why high temperature is safest (at low temp, the intermediate will accumulate). #chemtwitter #processchem
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6 Jun 2023
Welp guys, I'm proud to announce I moved to San Francisco and started at Genentech today!! Secret is out!!! Time to get my @SafeChem79 on and dive into the world of process chem!!! I switched to the dark side! #processchem #chemtwitter
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Throwback to when the Heidolph Hei-VAP was centre stage at @pentiredrinks photoshoot.
Need a demo? Simply choose a date/time that suits you & discuss your application with one of our experts- radleys.com/book/
#chemistry #chemist #realtimechem #processchem #heivap
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5 May 2023
The tosyl swap described here (Ar-OTs ROH —> Ar-OR) is very cool.
I recently tried to make a similar tosylate and only got subsequent replacement by Cl- or elimination. #chemtwitter #processchem
pubs.acs.org/doi/10.1021/acs…
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7 Apr 2023
Just saw a Ti(OEt)4 work up in a nature paper. Quench with water leads to lots of solid TiO2.
Better add THEED (alcohol form of EDTA) or aq potassium glycolate. This gives clear organic and water layers upon extraction.
#chemtwitter #processchem
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15 Mar 2023
Our COO Jeffrey Sherman and Director Henry Dubina representing Telescope this week at the @SciUP OPR&D Conference.
#OPRDNA23 #ProcessChem #EnablingTech
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12 Mar 2023
On large scale, you can't even do common lab techniques.
#processchem
11 Mar 2023
In the middle of helping with a manuscript that literally says "the med chem route was crap and this is how we fixed it for scale"
It's my team's med chem route and I agree with that assessment
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27 Feb 2023
Our first exhibition is coming up!
Catch us at the @SciUp OPR&D Conference in Clearwater, March 13-15. We'll be showcasing Telescope's ability to compress R&D timelines in the chemical and pharma industries.
#OPRDNA23 #ProcessChem #EnablingTech
23 Jan 2023
A previous attendee told us;-'OPR&D had the best line up of talks of all the events I attended in 2022. I recommend it for anyone interested in process dev in pharma.'
We hope you can join is in Clearwater. Register for #OPRDNA23 @ bit.ly/OPRDNA23
#OrganicChemistry
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10 Feb 2023
Lab chemist: *proud that a procedure requires only 1.1 eq iPrMgCl*
Process chemist: Please test large excess, then we don't need to quench the 200 L drum spearately. 🫠
#chemtwitter #processchem
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4 Feb 2023
If you are not able to reproduce a chemical transformation, it doesn’t mean that you are a bad chemist. It means that the procedure (or catalyst etc.) is not robust.
To proof the robustness, we often ask colleagues to repeat it.
#chemtwitter #processchem
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15 Jan 2023
So as the concept evolved, the idea seems to be to make it less and less like a classic machine, and instead replace by pure convenience (and reproducibility as our friends in #processchem would want).
That goal has been achieved. But first, they coaxed us along.
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Throwback to when the Heidolph Hei-VAP was centre stage at @pentiredrinks latest shoot.
Need a demo? Simply choose a date/time that suits you & discuss your application with one of our experts- radleys.com/book/
#chemistry #chemist #realtimechem #processchem #heivap
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9 Dec 2022
Just read in oprd : POCl3 (276 kg) in MeCN added slowly to a cold (! 🚩) solution of bicarbonate for quench.
We would never do it this way because cold temp slows down hydrolysis and leads to a runaway reaction. #processchem
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18 Aug 2022
Want to read about phosphazene bases used in BET inhibitor scale up? Of course you do.
First paper, now in OPRD 🍾
#processchem #chemistry #chemistrytwitter
doi.org/10.1021/acs.oprd.2c0…
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10 Aug 2022
We've completed a project funded by @Pfizer to evaluate how our advanced tech can benefit the pharmaceutical industry!
Read more at: newsfilecorp.com/release/133…
#Automation #EnablingTech #ProcessChem
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27 Jan 2022
Many roles: #ProcessChem (what I came for), #DiscoveryProcessChem (what, talk to biologists? I’m a phys org chemist), #EnablingTechnologies (passion unlocked), all at least 2x. 2 sites. Lots of outstanding science. Great colleagues – no tags since I’m sure I’ll forget someone.
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