#ProgrammedAging. #CellularMemory
<<In response to inflammatory triggers, HSPCs can store experienced information through epigenetic and metabolic reprogramming.
This allows sustained adaptations in hematopoiesis past the initial insult.
HSPCs pass these epigenetic programs on to their progeny. This results in an adapted behavior of the generated effector cells. Effectively, this makes the bone marrow a repository of innate immune memory, which can be recalled for adapted effector functions, a phenomenon termed central trained immunity>>
14 Oct 2025
Trained immunity: induction of an inflammatory memory in disease | Cell Research nature.com/articles/s41422-0…
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20 Mar 2023
Interesting new review on #ProgrammedAging: «Different species have lifespans that differ by at least 10^5, meaning that longevity is a genetically programmed species-specific trait.» Fig. 3. Epigenetics and aging (AP/DP= Aging/Developmental program). sciencedirect.com/science/ar…
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Dr. Josh Mitteldorf - IdeaXme - Programmed Aging - DataBETA Project youtube.com/watch?v=AJSDNg-T… #Ideaxme #ProgrammedAging #Evolution #DataBeta #Genetics #Epigenetics #Ecosystems #Health #Wellness #Longevity #Biotechnology #Aging #HealthSpan #LifeSpan #IraPastor #Bioquark #Regenerage
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18 Oct 2019
Dr. Josh Mitteldorf - IdeaXme - Programmed Aging - DataBETA Project youtube.com/watch?v=AJSDNg-T… #Ideaxme #ProgrammedAging #Evolution #DataBeta #Genetics #Epigenetics #Ecosystems #Health #Wellness #Longevity #Biotechnology #Aging #HealthSpan #LifeSpan #IraPastor #Bioquark #Regenerage
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