In vivo mRNA gene therapy platform reprograms cytotoxic T cells bioworld.com/articles/730983… #Biopharma #InVivo #Immunotherapy #mRNATechnology #LipidNanoparticles #LNP #TCellEngineering #CellularTherapies #Preclinical #Research #Science

In vivo nano-engineering T cells for CAR-T therapy. | Zhiyuan Zhong, Soochow Univ. | [50 days' free access] #TcellEngineering #polymersome #CellTherapy kwnsfk27.r.eu-west-1.awstrac…

💡T Cell Targeted Vectors for CAR Delivery – Christian Buchholz, PEI 💡Extracorporeal CAR Gene Delivery – @David_Peritt Lupagen 💡Non-Viral DNA-Based #GeneTherapy for CAR T Engineering – Jacek Lubelski, NanoCell 🔗 lymphocyte.kenes.com/program… #GeneTherapy #TCellEngineering

Antigen-specific immunotherapies for autoimmune disease ‼️ 🚀 Exciting advances in #Autoimmunity research! 🌐 🔍 **Key Focus Areas:** - **Functional Silencing**: Autoreactive T cells can be silenced via **anergy** or **tolerogenic signals** from dendritic cells (DCs). - **Significance of DCs**: Tolerogenic DCs induce **Treg** or **Tr1 cell development**, promoting **immune tolerance**. - **Innovative T Cell Engineering**: - **Genetic Manipulation** of Tregs enhances their suppressive functions. - **CAR Treg cells** leverage cutting-edge technology for targeted suppression. - **Antigen-Specific Strategies**: - **Targeted Deletion** of autoreactive lymphocytes to restore tolerance. - **Anergizing Methods** reprogram autoreactive lymphocytes into non-pathogenic forms. - **Nanoparticles & Liposomes**: Emerging as effective carriers for antigen delivery in promoting immune tolerance. - **B Cell Depletion**: - **Monoclonal Antibodies** and **CAR Therapy** targeting B cells show promise for conditions like **RA** and **SLE**. - **Future Directions**: - Focused research on specific characteristics of autoreactive lymphocytes is critical for refining therapies. 💡 **Challenge**: Selecting appropriate targets and ensuring contextual awareness are vital for success in therapeutic interventions. The future looks bright for antigen-specific therapies! 🔬✨ doi.org/10.1038/s41584-024-0… #Immunology #AutoimmuneDiseases #ResearchInnovation #TCellEngineering #CARtherapy #Nanotechnology #MedTwitter #RheumTwitter

Get your non-viral #Tcellengineering process ready for #clinicalmanufacturing This #FastFacts presents guidance on how to close and automate a #Tcell electroporation protocol, ready for clinical manufacturing View below: buff.ly/3RKL0qw

Get your non-viral #Tcellengineering process ready for #clinicalmanufacturing This #FastFacts presents guidance on how to close and automate a #Tcell electroporation protocol, ready for clinical manufacturing View below: buff.ly/3RKL0qw

ADDR 50 days' free access: Non-viral delivery of RNA for therapeutic T cell engineering. By Kevin Braeckmans & coworkers @UGent_Pharma @CRSBeNeLuxFr #nonviralvector #RNA #TcellEngineering authors.elsevier.com/a/1ijAe…

ADDR in press: Non-viral delivery of RNA for therapeutic T cell engineering. By Kevin Braeckmans & coworkers @UGent_Pharma @CRSBeNeLuxFr #RNAdelivery #NonviralVector #TcellEngineering doi.org/10.1016/j.addr.2024.…

Polymer- and lipid-based gene delivery technology for CAR T cell therapy. | Henrique Faneca @cnc_uc | @CRS_SPLC [50 days' free access] #genedelivery #celltherapy #Tcellengineering authors.elsevier.com/sd/arti…

Polymer- and lipid-based gene delivery technology for CAR T cell therapy. | Henrique Faneca @UnivdeCoimbra | @CRS_SPLC #genedelivery #celltherapy #Tcellengineering doi.org/10.1016/j.jconrel.20…

The T in T cell stands for Totallyawesome. #tcell #Tcellengineering #CARTcell

#ICLE22 is back in 2022–Save the Date! It is our pleasure to invite you to the 3rd International Conference on Lymphocyte Engineering on 31 March-2 April 2022 in Munich for a long-awaited face-to-face meeting! #Immunotherapy #GeneTherapy #TCellEngineering bit.ly/3hKIGwW

.@FierceBiotech reports on new Treg cell therapy startup GentiBio, cofounded by scientists from BRI, @seattlechildren Research Institute and MIGAL Galilee Research Institute. bit.ly/33vNyAj #Tcellengineering #Tregs #Tregcelltherapy

New research published in @ScienceTM highlights the latest milestone by research teams at BRI @seattlechildren's Research Institute to engineer and reprogram T cells to suppress an overactive immune response. Read more on the blog. bit.ly/2UoLjth #Tcellengineering #T1D

#CRISPR/#Cas9-modified #TCells could solve #immunotherapy problems: go.tum.de/364472 #TCellEngineering #CRISPRcas9