How to build a normal multilayered arterial wall?😎 Another amazing Smooth Muscle Cell story from @GreifLab🤠 Activated Sphingosine kinase 1 mediates elastin deficiency-induced arterial hypermuscularization Sphk1 KO in not only ACTA2 SMC (nearly completely), but also Cdh5 Endothelial Cell (20% effect size), restore developing aortic wall thickness & lumen area by P0.5🐭 @JunichiSaito_ @NatureCVR 2026 nature.com/articles/s44161-0… Only have access to preprint ver biorxiv.org/content/10.1101/…

Congratulations @JunichiSaito_ from @GreifLab for being selected as a finalist for the Elaine W. Raines Early Career Investigator Award at the AHA Scientific Sessions ‘24 for his work "Sphingosine Kinase 1 Is Integral For Elastin Deficiency-induced Arterial Hypermuscularization”

Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization biorxiv.org/cgi/content/shor… #biorxiv_devbio

Congratulations to @JunichiSaito_ on his NIH K99/R00 Pathway to Independence Award! With this award Dr. Saito will continue his exciting work in the lab on #elastin induced arterial #hypermuscularization @YaleCVRC @YaleCardiology @YaleGenetics @nih_nhlbi

Congratulations Dr. Junichi Saito and colleagues for their latest article on #presenilin and #SVAS @iScience_CP ! "Presenilin-1 in smooth muscle cells facilitates #hypermuscularization in #elastin aortopathy" is now published 👉 doi.org/10.1016/j.isci.2023.…

Online now: Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy dlvr.it/T21tks

#SmoothMuscleCell Presenilin-Notch hyperactivity mediates Aortic Multilayering hypermuscularization upon Elastin deficiency Eln-/- or /-🐭 Eln /-👤#SupraValvularAorticStenosis @GreifLab @iScience_CP 2024 sciencedirect.com/science/ar… How elastin insufficiency⏫Presenilin in SMCs? Via⏬DNMT1-> Another outstanding work👇 @GreifLab jci.org/articles/view/142338

Junichi Saito, MD, PhD, @GreifLab in @YaleCVRC presents, "Presenilin 1 Deletion in Smooth Muscle Cells Ameliorates Hypermuscularization and Stenosis in Elastin Aortopathy" at #AHA2023 Young Hearts Early Career Investigator Competition. bit.ly/3QS3u8M @YaleCVRC @YaleIMed

ACTA2 SMC, Not Cdh5 EC, KO of Jag1 normalized aortic hypermuscularization of Eln-/-🐭 No baseline aortic defects (Fig 9A,B) Previously Jag1 KO in Pax3 neural crest or Tie2 EC⏬aortic SMC A stage-specific Jag1-elastin interplay to control SMC differentiation/proliferation?🤠

#Aorta Multilayering controlled by Elastin-regulated DNA methylation😎 Eln KO -> ⏬DNMT1 -> ⏬5mC on promoters of Presenilin 1/2 & Jag1 -> ⏫#SmoothMuscleCell Notch3 -> 🐭aortic hypermuscularization Dr. Daniel Greif lab @jclinicalinvest 2022 @GreifLab jci.org/articles/view/142338

Our latest collaboration with Anne Joutel lab @CircAHA Protection against deep brain 🧠 hemorrhage by reducing hypermuscularization of vascular transitional segments ahajournals.org/doi/abs/10.1… @UVMLarnerMed @uvmcvri @uvmvermont @Nrklug @FondationLeducq @SVDs_at_target