私たちエンジニアの神にまで昇華しているスティーブ・ジョブズ氏。彼が罹った膵臓がんについてGemini AI壁打ち議論 膵臓がんはPDAC型がほぼ9割、PanNET型がほぼ1割。スティーブはPanNET型。現在の治療手法PRRTの成績はかなり向上している もし当時AppleにGeminiがあったらスティーブは助かったのか⁉️

Diagnosed with pancreatic NET? Help researchers shape a new quality of life approach. 🙏Please take part in a short survey in English to contribute to improving how quality of life is measured for PanNET patients. ☑️Find out more: incalliance.org/pancreatic-n… #LetsTalkAboutNETs

The 199 steps, Whitby museum in Pannet Park and the Greedy Pig hot pork sandwich shop.

When do you operate on a PanNET? A tough and nuanced call 😳 🦓 Unpacking that with @EAHPBA x @SocSurgOnc x @NANETS1 with @spartelli @decsamethasone @valentinandreas 📝 We will be drawing from recent @BJSurgery NETs commission paper ⏰May 21, 18:00 CEST - 🆓 registration 👇🏻

🔔Diagnosed with pancreatic NET? Help researchers shape a new quality of life approach. 📌Please take part in a short survey in English to contribute to improving how quality of life is measured for PanNET patients. ✅Find out more: incalliance.org/pancreatic-n… #LetsTalkAboutNETs

PanNETs are NOT pancreatic adenocarcinoma—and treating them the same is a mistake. 📊 Prospective data (ASPEN PANDORA): 👉 Surgery rate as low as 2–8% 👉 No survival disadvantage with surveillance Time to rethink small NF-PanNETs. #Oncology #PanNET #MedTwitter @OncoDailyGI @dr_yakupergun

🧠 Surgical management of PanNENs 🔹 Heterogeneous disease (G1–G3, functional vs NF) 🔹 Surgery remains cornerstone, even in selected metastatic pts 🔹 Growing role of systemic therapies → integrated approach 🔹 High variability in practice → need for standardization 💥 PanNET ≠ PDAC → different paradigm 🔗 doi.org/10.1093/bjs/znag026

I am looking forward to you doing the same with a PanNET (PNET) 😀

Wifi inafanya vizuri siku mzima alafu ikifika saa ya game inakatika, Pannet wifi providers tuache kupimana bana

❌ PanNET: • Well-differentiated neuroendocrine neoplasm with an organoid growth pattern. • Tumor cells show salt-and-pepper chromatin and are synaptophysin positive. • Can show a sclerotic pattern that mimics the appearance of a glandular lesion.

❌ PanNET: • Organoid growth pattern with uniform cells and salt-and-pepper chromatin.

If she's into it ill pull up a chair like like John Pannet to a buffet.

NOT a metastatic renal cell carcinoma on this liver FNA. The cytomorphology shown here is consistent with metastasis from the patient's known Pancreatic Neuroendocrine Tumor (PanNET). Cytoplasmic lipid vacuoles ("Soap Bubble" cells) are often seen in PanNET (primary and metastatic) and are helpful for the diagnosis.

He had a pancreatic neuroendocrine tumor. These have surprisingly good survivability (if treated properly), about 65 % of the patients diagnosed with a PanNET survive for at least 5 years (compared to 13 % for pancreatic cancer). His hesitation might just have cost him his life.

SEQTOR-GETNE Phase III Trial Updates This randomized phase III study compared everolimus and streptozotocin 5-FU (STZ/5-FU) as first-line treatment in advanced panNETs, and tested which sequence works best. 🔍 Key findings • No significant difference in PFS or OS between sequences • STZ/5-FU achieved significantly higher tumor response (~30% ORR vs ~10%) • Everolimus provided durable disease control • Safety profiles were different but manageable ➡️ Clinical message: treatment sequencing should be personalized, not fixed. @RamonSalazarS @AldoScarpa1 @merete_krogh @GCarboneroLab oncodaily.com/oncolibrary/se… #NeuroendocrineTumors #panNET #Oncology #ClinicalTrials #ESMO #Chemotherapy #GIOncology

Genetic profiling matters: MUTYH mutation-associated PanNET shows aggressive course, frequent grade progression, and poor OS. Multinational data highlight need for tailored strategies. #Oncology #PrecisionMedicine @RachelRiechelm2 buff.ly/5Jh8NHy

Closing the day with @SilviaUccella that highlights how a hybrid cyto-histological work-up sharpens diagnosis and grading of pancreatic neuroendocrine tumors (PanNETs) @JMP_MDPI #PanNET #Neuroendocrine #MolCytoPath25 @Sinchita_Roy @mdlozanoe @MariantoniaNac1

New in Endocrine Pathology! Integrated methylation transcriptomic profiling of MEN1 DAXX/ATRX-mutated PanNETs reveals 3 cluster subtypes, each with distinct biology and vulnerabilities. A step forward in refining PanNET classification! link.springer.com/article/10…

Pancreatic neuroendocrine tumours (PanNET) represent the most chemosensitive subtype of NET, with alkylating agents being the mainstay treatment for advanced-stage disease. However, disease progression remains inevitable and presents significant clinical challenges. This mini-review explores hypermutation in PanNET, with a focus on alkylating-induced changes, and considers the potential of immunotherapy in this context. Read the full article: bmjoncology.bmj.com/content/… #OncoAlert @OncoAlert

DLL3 in GEP-NENs: new therapeutic window 🔥 High DLL3 expression: 71% GEP-NECs, 40% G3 NETs, esp. PanNET G3 (43%) ⚠️ DLL3 G3 PanNETs → worse survival (HR 3.27) 🧪 DLL3-immunoPET detected avid lesions in 5/6 patients 💡DLL3: promising target for NEC & high-grade PanNETs 🔗 doi.org/10.1200/PO-25-00724