30 Jan 2024
It's kind of funny how in this digital day and age, getting your hands on the print edition of your paper still makes years of work more tangible... #Microscopy #Imaging #schmidtobjective nature.com/articles/s41587-0…
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15 Apr 2023
From macro- to microcosm: A feature on the 🔭telescope & 🐚scallop- inspired #schmidtobjective #Microscope 🔬objective in @ScienceMagazine @NewsfromScience by @Sara_Reardon! #Microscopy
science.org/content/article/…
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11 Apr 2023
#schmidtobjective exceptional working distance on this cleared Xenopus 🐸🐸 embryo. And all that with simple DAPI. Keep tuned for more crazy immunos on frogs using the schmidt!! 🚀 check out our other stains in our recent nat. biotech paper at nature.com/articles/s41587-0…
10 Apr 2023
Head of a Xenopus tapole 🐸 imaged with the reflective #schmidtobjective #Microscope objective 🔬 - thanks to @XenoThomasnaert @SLienkamp for the sample! #Microscopy #NationalFrogMonth #xenopus #devbio
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10 Apr 2023
Head of a Xenopus tapole 🐸 imaged with the reflective #schmidtobjective #Microscope objective 🔬 - thanks to @XenoThomasnaert @SLienkamp for the sample! #Microscopy #NationalFrogMonth #xenopus #devbio
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5 Apr 2023
This picture brings up memories: As a teenager, I spent many nights observing at the same telescope - a 0.5 m Zeiss Cassegrain with 7.5 m focal length @AIP_Potsdam @AstrophotonAIP - it's also where the roots of my #schmidtobjective work lie - from #Astronomy 🔭 to #Microscopy 🔬
4 Apr 2023
Katja Poppenhäger, Professorin an der Universität Potsdam und Leiterin der Abteilung Sternphysik & Exoplaneten am AIP, beantwortet auf der Seite des Wissenschaftsjahres @w_jahr drei Fragen zu ihrer Arbeit als Astrophysikerin:
wissenschaftsjahr.de/2023/ak…
#UnserUniversum
ALT Foto von Katja Poppenhäger, die angelehnt an ein Spiegelteleskop unter einer hölzernen Kuppel steht.
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31 Mar 2023
📢 Out today! 📢: The @NatureBiotech research briefing describing the #multiimmersion #schmidtobjective #Microscope objective and a glimpse into its origin story involving 🐚scallops and 🔭telescopes:
nature.com/articles/s41587-0…
Full article in @NatureBiotech:
nature.com/articles/s41587-0…
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31 Mar 2023
Here is the @UZH_en @UZH_Science news release on the mollusc-inspired #schmidtobjective microscope 🔬 objective developed in the lab of @FritjofHelmchen : news.uzh.ch/en/articles/medi…
#Microscopy #tissueclearing
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30 Mar 2023
This is one of the cooles projects we have been fortunate to be part of! Congrats @voigtvision! #schmidtobjective. Best last sentence of a paper ever!
30 Mar 2023
🚨📢 Now out in @NatureBiotech: The most fun #Microscopy 🔬 paper I've ever written with @FritjofHelmchen: The Schmidt objective - taking inspiration from 🔭 telescopes and 🐚 scallops to rethink the design of #multiimmersion #microscope objectives: nature.com/articles/s41587-0…
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30 Mar 2023
The other direction is the opposite:
2) The underlying simplicity of the #schmidtobjective makes it a good candidate to think about low-cost microscope objectives for low-resource settings
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30 Mar 2023
There are two opposite directions worth exploring that result from this #schmidtobjective work:
1) The usage of immersed mirrors opens up lots of design options for #Microscopy - especially when thinking about designing #mesolenses for gigantic FOVs at large NA
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30 Mar 2023
Here is an overview plot showing the #schmidtobjective in the context of currently available objectives suitable for imaging cleared tissue:
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30 Mar 2023
The cool thing is: This first-gen proof-of-concept #schmidtobjective has a larger NA, FOV, WD, and index range than any available #multiphoton @zeiss_micro @LeicaMicro @Evident_LS @NikonInst clearing objective - despite consisting of only two optical elements!
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30 Mar 2023
The #schmidtobjective sample holders are fully compatible with the #mesoSPIM #lightsheet #Microscope sample holders, so doing correlative #lightsheet and #multiphoton #imaging like in this 🐔chick embryo cleared by Martina Schaettin is pretty easy:
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30 Mar 2023
The #schmidtobjective is perfect for high-resolution #imaging in cleared samples - here is a BABB-cleared #Xenopus tropicalis 🐸tadpole by @XenoThomasnaert first imaged at low resolution with a #mesoSPIM #lightsheet #Microscope and then with the new #schmidtobjective
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30 Mar 2023
The #schmidtobjective has a unique property: It delivers an excellent PSF over a large FOV in air and in any homogeneous medium without any correction collar - the classical destinction between "air" and "oil" objectives in #Microscopy is meaningless here
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30 Mar 2023
Realizing this #idea was the hard part, but in the end I was able to conquer spills, misalignment, and other problems to arrive at a manufacturable #multiphoton #schmidtobjective that reaches NA 1.08 at an index of 1.56 - perfect for BABB, DBE, ECI and other media
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30 Mar 2023
Which field has mastered the art of building excellent optical systems with mirrors? #astronomy! So, let's take a Schmidt #Mirror #telescope, downsize it, put a sample inside, and get it work in all immersion media: Please welcome the Schmidt objective! #schmidtobjective
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18 Oct 2022
In the #schmidtobjective:
1) The mirror provides focusing power, but introduces a lot of spherical aberration (SA)
2) The front surface of the correction plate bends the wavefront to compensate this SA
3) The middle surface makes sure that this works in any homogeneous medium
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18 Oct 2022
Using the #mesoSPIM: A few minutes. Using the #schmidtobjective: This version is using point-scanning two-photon #Microscopy, so it takes much longer - usually hours.
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18 Oct 2022
14/n The other direction is the polar opposite:
2) The underlying simplicity of the #schmidtobjective makes it a good candidate to think about low-cost microscope objectives for low-resource settings
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