Mimo jiné jsem tu i počítala, proč valuebased daň v ČR je rovna vyvlastnění nemovitostí pro obrovskou část Čechů. Ale i kdyby to nebyla valuebased daň, bohatě stačí jednotlivé směrnice.

Most Azure programmes can answer "what did we deploy?" The harder question: what is measurably better because we adopted Azure? New post on shifting from cloud adoption to value realisation. #azure #cloudadoption #mvpbuzz #valuebased luke.geek.nz/misc/cloud-adop…

My entry didn't add somethings in the previous entry.... If I were CEO of MEXC for a day… I wouldn’t just pick one coin I’d create a 0-fee event. “Zero-Fee Rotation” 👇 Every 24 hours, the community votes one coin to trade with 0 fees. Not hype based but valuebased: real utility, real builders, real community. It turns trading into a competition, projects into contenders, and MEXC into the spotlight hub. Because the real move isn’t backing what’s big… it’s discovering what’s next. That's my idea 💡 UID: 43446477 #MEXC #MEXC0fee

If I were CEO of MEXC for a day… I wouldn’t just pick one coin I’d create a 0-fee event. “Zero-Fee Rotation” 👇 Every 24 hours, the community votes one coin to trade with 0 fees. Not hype based but valuebased: real utility, real builders, real community. It turns trading into a competition, projects into contenders, and MEXC into the spotlight hub. Because the real move isn’t backing what’s big… it’s discovering what’s next. That's my idea 💡

Swami Shraddhanand Jayanti A nation is built on the character of its people.- Swami Shraddhanand On his Jayanti, let us pledge to revive and integrate the ancient wisdom of our Rishis with modern, value-based education. #swamishraddhanandjayanti #revive #integrate #ancientwisdom #rishis #modern #valuebased #education #aryasamaj

Visited Niveditha Gurukulam, Sri Jayarama Vijnana Vihara E.M. School at Unguturu in Krishna District and participated in the New Building Inauguration and 2nd Annual Day celebrations. The occasion reflected the institution’s commitment to nurturing young minds through valuebased and holistic education.

Great #DTM2025 session on “Emerging Trends of Diabetes Tech”🎯 Based on @AmDiabetesAssn guidelines, presented by CSMO #RitaKalyani👍 - Tech dominates, but how about VBHC /PROMS?, behavioural aspects? and valuebased reimbursement? @DiabetesTechSoc @US_FDA #StenoNord @DiabetesDK

Truly inspiring words from JoJo to all Vietnam Pioneers! Your unity, leadership, and dedication are shining examples for the global GCV community.Vietnam is not just participating, you are leading the real transformation toward a transparent, ethical,valuebased digital economy.

Honored to moderate another all star cast at #AVBCC2025 with @Mark_Hiatt, @fjlexa, @DSmethermanMD, @sindhu_kunal, and Anh Ung on whether #valuebased payment is compatible with #radiology and #pathology Many thanks to the organizers at @avbcancercare & @JordanJ65544091 for my 5th year at #AVBCC

“Tell me how you get paid, and I’ll tell you who you are.” @AledadeACO CEO, @Farzad_MD about incentives for #outcomes and #valuebased care vs. FFS opportunities in #DigitalHealth at the Morningside Summit in #Boston

Patient-Centric Features in EMR Software emrsystems.net/blog/patient-… #EMRSystems #SimplifyingSelection #healthcare #digitalhealth #healthtech #doctors #hospital #health #software #EMRSoftware #PatientCenteredCare #EMRInnovation #PatientEngagement #PatientFirst #SmartEMR #ValueBased

#CardioKidneyMetabolic (CKM) syndrome is common, affecting >90% of US adults. Can we shape care models to address pt-centric, holistic care needs? In @JCFINT, we dive into the case for why the #ValueBased integrated care is the ideal model for CKM. @TdhDoc onlinejcfi.org/article/S3050…

Through the #InterfaithDialogue, we are bridging gaps between faith, health and community to advance young people’s SRHR. Recently, religious leaders from across Uganda united to learn, reflect and commit to delivering safe, informed and valuebased guidance in their communities

Credit gating hints at valuebased incentive alignment. Will this reshape task prioritization?

Then there can be no valuebased judgement at all nor morale, it's determined by previous actions so why is he arguing about telling the truth at all. If you had lived your life perfect you wouldnt be in a situation where you had to tell the truth and accept the concequences. Only bad and hard desicions of value happen to those who have brought it upon themselves after all. What a load of horseshit; just the notion that the world rotates around you without history or actions outside of your scope of reach. I kidnap you in the middle of the night and throw you into a white room where you have to shoot a cat or a dog or both die you go with wooo-wooh logic saying "I wouldn't be in that situation if I had lived in a castle with a bolted door". Just fuck off. He embaressed himself and no stern tone of voice can save that.

$UNH JPMorgan analyst Lisa Gill reiterated an Overweight rating and $405.00 price target on UnitedHealth Group (NYSE: UNH). The analyst comments "This morning, The Guardian published the first in what appears to be a series of pieces on UNH, focusing on what we believe are relatively normal-course valuebased contracts and several incidents (primarily in 2019) around UNH’s review of hospitalizations. We are not surprised that UNH focuses on Admissions Per 1,000 (APK) as we believe this is a common way to evaluate a facility’s ability to proactively manage care and avoid costly hospitalizations. Decisions around hospitalization are challenging, and while there are anecdotes cited in the article relating to UNH and nursing facilities navigating go/no-go hospitalization decisions, we do not think that structures that reward low APK facilities are drivers of broad-based inappropriate behavior. To that end, much of what has been discussed in the article has been previously investigated according to UNH, with the DOJ declining to charge the company. On balance, while we appreciate that investors are still digesting the significant changes in the last six weeks, at this valuation level, we remain constructive on UNH and view today’s movement as overdone." @Street_Insider

Gene Therapy in SCD & Thalassemia 🧬🩸 1️⃣ Goal: Fix the genetic defect causing SCD (HbS) or β-thalassemia (β-globin mutation) ➤ Either correct the gene OR reactivate HbF #GeneTherapy #SCD #TDT ⸻ 2️⃣ Key Platforms: 🔹 Lentiviral Vector Gene Addition 🔹 CRISPR-Cas9 Gene Editing #CASGEVY #ZYNTEGLO ⸻ 3️⃣ CASGEVY™ (exa-cel) ➤ CRISPR-Cas9 edits BCL11A enhancer in autologous HSCs → ↑HbF ➤ Approved: US, EU, UK for SCD & TDT ➤ Curative in most patients Ref: Frangoul H, N Engl J Med 2021 #CRISPR #HbF ⸻ 4️⃣ ZYNTEGLO® (beti-cel) ➤ LentiGlobin BB305: β-globin gene insertion into HSCs ➤ For TDT, especially non-β⁰/β⁰ ➤ 90% transfusion independence Ref: Thompson AA, N Engl J Med 2018 #Thalassemia #LentiGlobin ⸻ 5️⃣ Eligibility ➤ Age 12 ➤ No active infections ➤ No advanced organ damage ➤ ECOG 0–2 ➤ HSCT not feasible or no matched donor #PatientSelection #HSCTAlternative ⸻ 6️⃣ Procedure Steps 1.HSC collection 2.Ex vivo gene editing or transduction 3.Myeloablative conditioning (Busulfan) 4.Reinfusion 5.Engraftment & monitoring #GeneTherapySteps ⸻ 7️⃣ Efficacy CASGEVY: ➤ ~94% SCD free of VOCs at 12 mo ➤ ~88% TDT transfusion independent ZYNTEGLO: ➤ ~90% transfusion-free [Ref: NEJM 2021; NCT03655678, NCT03745287] ⸻ 8️⃣ Safety Concerns ➤ Busulfan-related toxicity ➤ Insertional mutagenesis (lentiviral) ➤ Long-term cancer risk under surveillance #SafetyFirst #Myeloablation ⸻ 9️⃣ Cost & Access ➤ CASGEVY: ~$2.2M USD ➤ ZYNTEGLO: ~$2.8M USD ➤ High upfront, but potentially curative ➤ Global access remains limited #Pharma #Equity #ValueBased ⸻ 🔟 Future Directions ➤ Non-genotoxic conditioning ➤ In vivo editing ➤ Expanded eligibility (peds, comorbidities) #FutureOfTherapy ⸻ Conclusion Gene therapy is transformational in SCD & TDT ➤ Curative for many ➤ Requires specialized centers ➤ Safety & equity still major priorities #Hematology #SickleCell #Thalassemia #GeneTherapy #CRISPR

Have you seen #valuebased health care in action? The @uthealthaustin MSK Institute Immersion Program in #VBHC @DellMedSchool gives participants an in-depth look into #valuebased payment and delivery models. Hope you can join us in Austin on 9/18 – 19! dellmed.utexas.edu/units/dep…

How are companies optimizing for #RevenueGrowth? Take our survey to explore: ✅ #AI in pricing & customer retention ✅ Strategies for #ValueBased & #OutcomeBased pricing ✅ Overcoming challenges in pricing model transitions 📊 Share your insights now: bit.ly/4376kx2