π¨π¦ in UK. Assistant Prof studying polygenic scores & multimorbidity @Cambridge_Uni/@PGSCatalog /@ChurchillCol. PhD studying TFs @UofT. Views are my own.
Joined April 2011
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May 20
Interested in using multi-omics imputation or TWAS/PWAS approaches? Frustrated by the models being spread across multiple resources? Enter OmicsPred: a centralised resource for genetic prediction of multi-omic traits!
π : omicspred.org
π : medrxiv.org/content/10.64898β¦
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Sam Lambert retweeted
π¨ Funded PhD Opportunity (Oct 2026 start)
10 funded 4-year PhD studentships are available through @TheBHF doctoral training programme focused on preventing cardiovascular disease through innovative, data-driven approaches
For more info & how to apply: tinyurl.com/yc7j5s67
ALT Human heart with blood vessels. 3d illustration
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Sam Lambert retweeted
Jan 19
It's very hard to prevent vasovagal reactions, such as fainting, as evidenced from this study of nearly 1.4 million blood donors
thelancet.com/journals/lanhaβ¦
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Sam Lambert retweeted
15 Dec 2025
We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/β¦) & All of Us (pgsc-calc.readthedocs.io/en/β¦ )! But feel free to contact us on Github: github.com/PGScatalog/pgsc_cβ¦!
With that, happy holidays from the PGS Catalog team! π π
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Sam Lambert retweeted
15 Dec 2025
The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/pgsc_cβ¦
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Sam Lambert retweeted
15 Dec 2025
Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/β¦
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Sam Lambert retweeted
New paper in @ESC_Journals
@sritchie73 & colleagues found integrating genetic & metabolic blood tests with existing clinical data could enhance how doctors identify people at high risk of heart disease, leading to earlier prevention strategies
Read more: tinyurl.com/bp5tjck2
ALT Human heart with blood vessels. 3d illustration
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Sam Lambert retweeted
5 Nov 2025
Today, we're celebrating a two-decade milestone: on November 5th, 2005, we broke ground at the Donnelly Centre!
Thank you to everyone who has made Donnelly the building it is today!
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Sam Lambert retweeted
π¨ Exciting new PhD Opportunity π¨
Applications are open for 3-year non-clinical PhD studentships with the BHF Cambridge Centre of Research Excellence
π
Apply by 23 Nov 2025
π Open to UK & international applicants
Find out how to apply here: tinyurl.com/3t59uwbn
ALT The Relationship Between Genetic Factors and Heart Function - Conceptual Illustration
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"This study demonstrates that PRS, when incorporated into existing risk prediction frameworks, are unlikely to meaningfully exacerbate disparities in CVD risk stratification."
medrxiv.org/content/10.1101/β¦
19 Sep 2025
Algorithmic fairness metrics are increasingly used in AI/ML to assess model bias. A clever PhD student (@claireicoffey) suggested applying these methods to clinical risk prediction or polygenic risk scores. See our new preprint for the whole story : medrxiv.org/content/10.1101/β¦
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19 Sep 2025
Algorithmic fairness metrics are increasingly used in AI/ML to assess model bias. A clever PhD student (@claireicoffey) suggested applying these methods to clinical risk prediction or polygenic risk scores. See our new preprint for the whole story : medrxiv.org/content/10.1101/β¦
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6 Mar 2025
Congratulations @claireicoffey on passing your PhD viva (it's not everyday your first PhD student graduates)! It's been a pleasure to supervise your work applying algorithmic fairness techniques to risk prediction models and polygenic scores with Angela Wood & Mike Inouye.
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4 Mar 2025
π£ Thrilled to announce our collaborative tutorial with @EBItraining! Dive into the world of polygenic scores and explore the PGS Catalog resources (including pgsc_calc) - ideal for those seeking a comprehensive yet quick overview. Access it online at buff.ly/CEBWMio!
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Sam Lambert retweeted
From @sangerinstitute and the CEU!
Translating genetic changes into future health impact
New resource helps bridge the gap between identifying genetic changes linked to health conditions & understanding how these changes impact biological processes
πtinyurl.com/3fs4prt3
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Sam Lambert retweeted
New PhD studentship opportunities!
The Cambridge BHF CRE will be funding non-clinical 3-year PhD studentships, with a hope to recruit people interested in interdisciplinary projects
πFor more information & how to apply please visit jobs.cam.ac.uk/job/49483/
π
Apply by 16 Jan!
ALT Cartoon of College and university students, researchers and professors studying together, school supplies and digital tablet: education and research concept
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5 Nov 2024
π’Fully-funded PhD studying the comorbidities of high adiposity. π: jobs.cam.ac.uk/job/48333/ (2 weeks left, due November 20)
Great work environment @CAMBRIDGE_CEU @HLRI_Cambridge, collab with @AstraZeneca @MikeXiao_JIANG @CambridgeATS.
DM or e-mail for informal enquiries.
18 Sep 2024
Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded studentship w/ @MikeXiao_JIANG π: jobs.cam.ac.uk/job/48333/ (due October 31)!
@CAMBRIDGE_CEU @HLRI_Cambridge @Cambridgecardio @DPHPC @CambridgeATS
ALT Project description for "Partitioning the effects of high body mass index on risk of future comorbidities".
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Sam Lambert retweeted
30 Oct 2024
HELP!
Which information would you like to see in @GWASCatalog regarding #ancestry?
π Fill out the survey (less than 1 min!)
shorturl.at/kkCEZ
π£οΈ Share with #gwas colleagues
#OpenAccess #Diversity #FAIRprinciples
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Sam Lambert retweeted
18 Oct 2024
π₯π₯π₯New preprint π₯π₯π₯on the EuPRI resource. Where we reconstruct the motifs for 34,736 RBPs and study their function and evolution.
Joint work with @ProfTimHughes (Toronto), Matt Weirauch, @LXandR_, Deb Ray, Kaitlin Laverty and many more. More details to come
18 Oct 2024
Reconstructing the sequence specificities of RNA-binding proteins across eukaryotes biorxiv.org/cgi/content/shor⦠#biorxiv_genomic
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Sam Lambert retweeted
18 Oct 2024
Weekly recap: Nextflow workflow for polygenic scoring, WES imputation > WGS, DL method for splice site prediction, metagenomics profiling, and a new NIST/GIAB matched tumor-normal with 13 sequencing modalities 1/ π§΅
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Sam Lambert retweeted
9 Oct 2024
We are looking for a new colleague!
9 Oct 2024
We are recruiting a colleague in the Donnelly Centre at the University of Toronto. We are looking for an assistant professor in the broad area of functional genomics: jobs.utoronto.ca/job/Toronto⦠closing date is Jan 16, 2025 @DonnellyCentre @UofT @uoftmedicine
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