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Dr. Scott C. Ritchie @sritchie73

Senior Research Associate in the Cardiovascular Epidemiology Unit, University of Cambridge, UK.

Joined April 2010
  • Tweets 3,180
  • Following 849
  • Followers 691
124 Photos and videos
Dr. Scott C. Ritchie retweeted
Sam Lambert@iamslambert
30 Sep 2024
Check out the latest developments of all things @PGSCatalog, out now in @NatureGenet (šŸ”—: rdcu.be/dVakA )! In this paper we describe big increases in the data content (and diversity) and our tool for PGS calculation (github.com/PGScatalog/pgsc_cā€¦).
Sam Lambert@iamslambert
1 Jun 2024
Excited to share our new preprint describing updates to the @PGSCatalog (PGSCatalog.org ) and the PGS Catalog Calulator (pgsc_calc), a new tool for reproducible PGS calculation in the context of genetic ancestry (github.com/PGScatalog/pgsc_cā€¦). Just in time for #ESHG24! /šŸ§µ
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Dr. Scott C. Ritchie retweeted
Stephen Burgess@stevesphd
12 Sep 2024
New manuscript "Addressing the credibility crisis in Mendelian randomization" is out at @BMCMedicine: bmcmedicine.biomedcentral.coā€¦. We discuss the explosion in MR studies, and what can be done by authors and editors/reviewers to improve the quality of published MR research. Thread:

Addressing the credibility crisis in Mendelian randomization

BMC Medicine - Genome-wide association studies have enabled Mendelian randomization analyses to be performed at an industrial scale. Two-sample summary data Mendelian randomization analyses can be...

link.springer.com
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Dr. Scott C. Ritchie retweeted
Aleksejs Sazonovs@alehins
6 Jul 2024
I genuinely think RAP is not a bad idea for lots of analyses but 1) this explicitly kills off lots of integrative work where you want to join your data with UKBB but canā€™t upload it to a cloud 2) immediate rule change with no grace period is baffling community.ukbiobank.ac.uk/hcā€¦

Changing the way UK Biobank data is made available to researchers around the world

From today, all data for new projects and additional data for existing projects will be available solely (with limited exceptions) on UK Biobankā€™s cloud-based Research Analysis Platform (UKB-RAP). ...

community.ukbiobank.ac.uk
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Dr. Scott C. Ritchie retweeted
Verena Zuber@VerenaZuber
24 Jun 2024
New preprint: We introduce MrDAG the first causal graphical model for Mendelian randomization (MR) to detect dependency relations within multiple exposures and within multiple outcomes to pinpoint which exposures cause disease biorxiv.org/content/10.1101/ā€¦ Follow šŸ§µ for more. 1/
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Dr. Scott C. Ritchie retweeted
Brooke N. Wolford, PhD@bnwolford
4 Jun 2024
Congrats @ceclindgren! How lucky our field is to have you! šŸŒŸ#eshg2024
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Dr. Scott C. Ritchie retweeted
Stephen Turner šŸ¦‹ @stephenturner.us@strnr
3 Jun 2024
The Polygenic Score Catalog: new functionality and tools to enable FAIR research medrxiv.org/content/10.1101/ā€¦ PGS calculator nextflow pipeline for polygenic score calculation github.com/PGScatalog/pgsc_cā€¦

The Polygenic Score Catalog: new functionality and tools to enable FAIR research

Polygenic scores (PGS) have transformed human genetic research and have multiple potential clinical applications, including risk stratification for disease prevention and prediction of treatment...

medrxiv.org
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Dr. Scott C. Ritchie retweeted
Mahsa Shabani@Mahsashabani
2 Jun 2024
Session towards #equity in genomics calling for large-scale African data collection for PRS #eshg2024
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Dr. Scott C. Ritchie retweeted
Kaitlin Samocha@ksamocha
1 Jun 2024
.@konradjk #eshg2024: Biobanks allow us to do "all by all" analyses, where you test the millions of genetic variants against thousands of phenotypes. Points to work with UK Biobank, specifically Pan-UKB (pan.ukbb.broadinstitute.org/) and Genebass (app.genebass.org/).

Pan UKBB | Pan UKBB

Description will go into a meta tag in

pan.ukbb.broadinstitute.org
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Dr. Scott C. Ritchie retweeted
Daniel MacArthur@dgmacarthur
1 Jun 2024
Exciting plans for the next gnomAD (v5) release, including integration of >400K diverse genomes from the All Of Us program, plus federated model to integrate data from national projects around the world (including Australia!). #eshg2024
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Dr. Scott C. Ritchie retweeted
GUIOMAR@guionanclares
1 Jun 2024
Keep this in mind when indicating that "the variant was not present in general population databases". Maybe your patient's population is underepresented. Slide from @ksamocha #ESHG2024
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Dr. Scott C. Ritchie retweeted
Tuomo Hartonen@tuomohartonen
1 Jun 2024
How well do EHR-based scores predict disease onset compared to PGS? Can we predict disease onset in Finland using EHR-scores trained in the UK or Estonia? To find out what our @intervene_eu study discovered, come see our poster at #ESHG2024 on 3.6. at 15:45
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Dr. Scott C. Ritchie retweeted
Daniel MacArthur@dgmacarthur
1 Jun 2024
Delighted to be in Berlin for #eshg2024! My team at the Centre for Population Genomics in Australia is looking for a senior computational biologist - if this is you, and youā€™re interested in relocating to Sydney, Melbourne, or NZ, Iā€™d be happy to chat! populationgenomics.org.au/caā€¦

Careers - Centre for Population Genomics

populationgenomics.org.au
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Dr. Scott C. Ritchie retweeted
Sam Lambert@iamslambert
1 Jun 2024
If youā€™re at #ESHG24 and interested in all things @PGSCatalog & calculator (pgsc_calc) weā€™ll be giving a workshop on Monday (2 PM, shorturl.at/zYurA) with our @GWASCatalog colleagues. But do DM if you want to chat or meetup at the conference! x.com/GWASCatalog/status/179ā€¦

NHGRI-EBI GWAS Catalog@GWASCatalog
31 May 2024
Are you going to #eshg? Join our workshop shorturl.at/zYurA and learn how to: šŸ“°Prepare your data for submission to the @gwasCatalog and @PGSCatalog āœ…Access harmonised #gwas #SumStats and scores šŸ§®Calculate scores from existing PGS in new samples using PGSC_calc?
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Dr. Scott C. Ritchie retweeted
Sam Lambert@iamslambert
1 Jun 2024
We also describe the PGS Catalog Calculator (pgsc_calc; github.com/PGScatalog/pgsc_cā€¦), an open-source, scalable and portable pipeline to reproducibly calculate PGS in the context of genetic ancestry using reference data panel data from HGDP 1kGP. Prior šŸ§µ: x.com/PGSCatalog/status/1688ā€¦
PGS Catalog@PGSCatalog
8 Aug 2023
šŸ“¢MAJOR UPDATE! Genetic ancestry differences are a big challenge for polygenic scores. We @PGSCatalog have updated our calculator with multiple methods to normalise for ancestry. Check it out: pgsc_calc v2: github.com/PGScatalog/pgsc_cā€¦
Distributions of PGS in different genetic ancestry groups

ALT Distributions of PGS in different genetic ancestry groups

Subway map describing v2 of the pgsc_calc nextflow pipeline

ALT Subway map describing v2 of the pgsc_calc nextflow pipeline

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Dr. Scott C. Ritchie retweeted
Sam Lambert@iamslambert
1 Jun 2024
Excited to share our new preprint describing updates to the @PGSCatalog (PGSCatalog.org ) and the PGS Catalog Calulator (pgsc_calc), a new tool for reproducible PGS calculation in the context of genetic ancestry (github.com/PGScatalog/pgsc_cā€¦). Just in time for #ESHG24! /šŸ§µ

medRxiv@medrxivpreprint
31 May 2024
The Polygenic Score Catalog: new functionality and tools to enable FAIR research medrxiv.org/cgi/content/shorā€¦ #medRxiv
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Dr. Scott C. Ritchie retweeted
Nicole Soranzo@nicolesoranzo
30 May 2024
Heading to #eshg2024 shortly - we have four post doctoral positions in computational genomics, graph genomes, blood single cell genomics, and statistics coming online soon - get in touch if you are interested in meeting up and discussing any of these
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Dr. Scott C. Ritchie retweeted
Elise Needham@elise_needham
30 May 2024
Thanks for the support, @CAMBRIDGE_CEU! I'm excited to continue working with the CEU and to get to know the @Royalcom1851 community.
BHF Cardiovascular Epidemiology Unit at Cambridge@CAMBRIDGE_CEU
30 May 2024
Congratulations to @elise_needham who was been awarded a Fellowship from the Royal Commission for the Exhibition of 1851! šŸŽ‰ She aims to determine genetic influences on cellular signalling by performing genome-wide association studies on protein post-translational modifications.
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Dr. Scott C. Ritchie retweeted
Belinda Phipson@BelindaPhipson
9 Apr 2024
The first paper from the Phipson lab has been published today in Genome Biology! Very proud to share this work, led by the talented @givanna90. SuperCellCyto: efficient analysis of cytometry data. A quick summary follows. genomebiology.biomedcentral.ā€¦

SuperCellCyto: enabling efficient analysis of large scale cytometry datasets

Genome Biology - Advancements in cytometry technologies have enabled quantification of up to 50 proteins across millions of cells at single cell resolution. Analysis of cytometry data routinely...

link.springer.com
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Dr. Scott C. Ritchie retweeted
Elise Needham@elise_needham
14 Mar 2024
1/ We are excited to share our preprint on how insulin resistance reshapes human skeletal muscle signalling, and how exercise partially counteracts these effects šŸƒ medrxiv.org/content/10.1101/ā€¦ šŸ§µA thread:

Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to...

Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the precise mechanisms is incomplete. Here, we investigate how insulin resistance alters signalling responses in...

medrxiv.org
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