I always get the "surprise look" whenever I said we routinely get high recovery and above 95% viability for our cryopreserved PBMCs; maintaining metabolic and immunologic integrity (including monocytes).
Well here we share all the little secrets!
#flowcytometry#immunology
This method gives >95% viability of PBMCs after freeze/thaw!
The Multiparametric Analysis of Mitochondrial Dynamics in T Cells from Cryopreserved Peripheral Blood Mononuclear Cells (PBMCs)
#flowcytometry#immunometabolism#Immunologybit.ly/3gwLHhA
SARS-CoV-2 the virus that causes COVID-19, appears to infect immune cells.
Does it that mean it targets the very cells needed to counteract it?
#COVID19#SARSCoV2nature.com/articles/s41577-0…
We are looking for a great postdoc candidate to join us in exploring breast cancer anti-tumor immunity and the role of the microbiome on our multidisciplinary R01 funded team. Check it out! @MakowskiLab#UTHSC#MEMPHISnature.com/naturecareers/job…
If you're interested in immunometabolism, there's a great opportunity to come and join our team! After 1 year in the Lynch lab, I can confirm these are a great bunch of people to work with!
Postdoc position available in Lynch Lab on COVID and obesity related project. Human immunology and/or metabolism experience a bonus. We are a friendly international team!
Effector response of immune cells to unique activating cues requires specific cellular adaptations.
Fascinating new perspectives discussed here: Metabolic signaling in T cells.
Enjoy!
go.nature.com/33bDoVm#immunometabolism#metabolism#Immunology
Dysfunctional T cell metabolism disrupts their function.
Thought I would share this fascinating article: Targeting Metabolism to Reverse T-cell Exhaustion in Chronic Viral Infections. @ImmunoMet#Virus#metabolism#immunometabolismbit.ly/32XQe9F
In this review article 📚 , the authors look at the role of aconitate decarboylase 1 as a regulator of #immunometabolism in inflammation and infection.
go.nature.com/3ig6lVt
Our very first bioRxiv-posted manuscript! Hope this nice work from PhD student Patrick van der Zande on the immunometabolic properties of the helminth glycoprotein omega-1 will find a cosy home soon. @LUMCPara #helminths#immunometabolismbiorxiv.org/content/10.1101/…
From 2017- interesting ideas here on how metabolism might be manipulated to enhance anti-viral immunity. Pre-COVID19 but highly relevant to my lab and many others.