How a restricted diet (DR) improves the immune response to cancer and success of immunotherapy in the experimental model. T cell metabolic reprogramming @NatMetabolismnature.com/articles/s42255-0…
Top #Citations 2025: 5️⃣
@VishwaDeepDixi1et al (@YaleMed) show that cysteine depletion leads to adipose tissue browning and rapid weight loss in mice and humans.
nature.com/articles/s42255-0…
All in all, this work suggest that the anti-tumor effects of calorie restriction works in part by boosting anti-tumor T cell responses. Our study adds to the exciting new work out recently indicating that nutrition plays an important role in immunity against cancer.
Epigenetic scarring after chronic infection or cancer can lock immune cells into a dysfunctional state.
Here, @Hazemghoneim11 & team @OhioState develop an in vitro model of terminal CD8 T cell dysfunction that better mimics in vivo exhaustion.
insight.jci.org/articles/vie…
#GLP1 medicines now address weight loss and other health conditions through innovative formulations and expanded indications, highlighting key questions about their efficacy and safety.
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ALT JAMA article 'New Molecules and Indications for GLP-1 Medicines'. Diagrams show Semaglutide, Tirzepatide for approved medications, Retatrutide, Survodutide for emerging medications. Approved indications listed: obesity, type 2 diabetes, sleep apnea, etc.