esports is dead long live gaming

Roots is a grassroots organization built by, and for, the people of our community. These people are the heart of what makes Melee Melee and what makes Roots Roots. Listen to some of our organizers talk about the ambitious project we're building here.

Now that everyone can see firsthand the success of congestion pricing in NYC, looking back on the environmental review process feels even more absurd. 4,000 pages and 3 years of review to study the environmental impact of… using cameras and prices to reduce traffic.

All of these were reported over the past month: • A new pancreatic cancer drug, daraxonrasib, that roughly doubles survival in late-stage disease • A precision lung cancer drug, lorlatinib, that kept 55 percent of patients progression-free after 7 years, versus 3 percent on the old drug • A prostate cancer drug, talazoparib, that halves the risk of progression • An endometrial cancer drug, dostarlimab, where 58 percent of patients hadn't progressed after 4 years, versus 16 percent on chemo alone • An early-detection blood test, the NHS Galleri test, that quadrupled cancer detection but missed its main goal • An mRNA cancer vaccine that halved the risk of melanoma recurrence when added to Keytruda • The most effective weight loss drug so far, retatrutide, which cut body weight by about 28 percent • The first in vivo gene editing therapy, which cut hereditary angioedema attacks by 87 percent from a single injection • A one-time gene edit, VERVE-102, that lowered LDL cholesterol by 62 percent • A feat of pharmaceutical synthesis that raised enlicitide's manufacturing yield 14-fold using engineered enzymes • A functional cure for hepatitis B, bepirovirsen, that cleared the virus in about 20 percent of patients • The discovery that human cells can swap chromosome-sized DNA through nanotubes • An ancestor of CRISPR, VIPR, found in bacteriophages, that silences genes without cutting DNA • A preventive Covid-19 pill, ensitrelvir, that cut symptom risk by 67 percent after exposure • The first PROTAC drug, vepdegestrant, which destroys a disease-causing protein rather than blocking it Every month, Niko and I write a round up digging into the latest news in biotech and medicine, and this month's was astonishing. We share some thoughts on what's responsible for this progress and what it means for science in the future.

and those golf courses are often on actually valuable urban land >:( double opportunity cost

Last June we passed AB 130, which included a CEQA exemption for infill housing—clean and simple. But passing a bill is not the same thing as solving a problem. And solutions are what we should be held accountable to, so let’s take stock and see where we’re at. 🧵/8

I am 30 My 20s were devoted to competition. Learning about myself through this avenue came with extremes, but ultimately I am grateful The person I am today wants to be great at many things. I want to be a wonderful friend and family member, because the friends and family that I have are wonderful. I want to be a great entertainer and push myself to excel in things that might not come naturally to me. And without losing sight of any of that, I want to be the greatest person to ever touch Melee. I've learned that I'm someone who wants it all.

in most of america you experience a title run through a television in a living room you drove to. in new york the game was projected on the sides of buildings and strangers hugged on the sidewalk at midnight. density is just the precondition for collective joy

The Foam Prop Sword Incident.

We made something for you. #FullHouseSiege #ThankYouMelee

Battle of bc back to back champ This one’s dedicated to cody schwab Now we go home and get bowser to GM I’m done playing

I am once again reposting E.B. White

i’m convinced car dependency and suburban sprawl promoting anti-social attitudes like “being in a public place with strangers is scary and bad” majorly contributes to why so many people are extremely regressive, tribalist, and paranoid these days

A low-slung commercial building turns into 50 homes in Berkeley. (2019➡️2025)

Apartments are legal on just 12% of US residential land, versus 95% for single-family homes. Even cities that welcome housing see that collapse at the city limits; Charlotte allows multifamily on 84% of its land, but just 7% across its suburbs.

For perspective, the East Germans over the course of nearly 3 decades, killed 140 trying to cross over the Berlin Wall.

Lucky Stats Premium is here $4.99/mo

a standing ovation for daraxonrasib at asco. over 40k oncologists, entrepreneurs, investors, and patient advocates together celebrating revmed's breakthru in the fight against pancreatic cancer. u never forget these moments. it's what innovation is all about.

we cannot look at housing or transportation in a vacuum. connecting them creates a flywheel effect where land value funds transit expansion this was common sense a century ago, as subway lines were built in tandem with brand new neighborhoods. glad to see we’re bringing it back