re.search(r'pathology|markets|AI',tweets)
Joined February 2011
- Tweets 11,948
- Following 776
- Followers 5,151
- Likes 1,536
1,091 Photos and videos
Jim retweeted
Jun 6
This is an insane paper and I love it
arxiv.org/abs/2605.31514
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Jun 2
Devilishly clever.
"In the end, it was protein-protein interactions all along" (topic of my grad thesis)
Jun 1
two flavors, broadly:
PROTACs
pull the target to the cell's garbage disposal and have it shredded.
molecular glues
force two proteins to stick that never would, building a brand-new function.
suddenly "undruggable" just meant "we hadn't found its partner yet."
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Jun 2
Blocking single proteins never really made sense to me, frankly, with the combinatorial explosion that PPIs get you (an N^2 process vs a N process). Much more specificity using PPIs
Funnily enough imatinib was also based on "PPI" (though in that case the proteins are fused)
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Jun 2
The imatinib of this generation.
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer
Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived
#ASCO26
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Jim retweeted
Jun 1
RAS finally getting drugged is one of the great stories in modern biology, and almost nobody outside oncology understands why it's such a big deal.
YOU'LL LEARN SOMETHING AWESOME TODAY.
i am going to keep this as understandable (and simple) as i can.
OPEN THE THREAD.
🧵
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer
Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived
#ASCO26
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4 Apr 2025
Interesting that the btc complex is acting as risk-off today, despite this clearly being a liquidity event. Won't be too quick to judge though.
Dynamic correlations are dynamic
18 Apr 2022
*currently*, btc is correlated with general risk on bets. I suspect that will change as noise traders make up a proportionally smaller piece of market.
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Jim retweeted
7 Mar 2025
The code is published online, just a tiny bit of Python.
Here’s a breakdown of the regex one-liner:
- lookbehind to skip signal peptides
- scan for rare amino pairs (KK, KR, etc)
- prevent false cleavage match
- enforce minimum spacing recursive pattern match
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9 Mar 2025
Tech bros and diagnostic laboratories:
“AI and robots will change the world”
People who actually work in laboratories:
“Can we please get better liquid handlers that don’t break or screw up every week? Pretty please?”
7 Mar 2025
Tech bros who've never been in a manufacturing facility:
HUMANOID ROBOTS ARE THE FUTURE OF MANUFACTURING!!!1
Actual manufacturing people:
Can you just make the robot arms, gantry robots, and CNC machines easier to program and more reliable please?
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9 Mar 2025
“Can people please read the SOP before sending another mass email”
“Can this reagent lot actually work this time”
“Can tech support pick up the phone when I’m calling them”
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28 Feb 2025
Totally. From path standpoint the only way to do this trial appropriately is the Moderna approach (vaccine ICI vs ICI).
27 Feb 2025
Fine, here we go.
First let's start with some baseline expectations. Pancreatic cancer is scary, 5y survival is ~10%.
So if you see a trial with an apparent survival asymptote at ~50% then certainly *something* is happening, right?
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Jim retweeted
8 Feb 2025
🧵 Many “hot takes” about the reduction of @NIH indirect grant costs to 15%.
Let’s lay out the facts about the university grant management process & accounting. And then use this to project likely short and longer term impacts of the policy.
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24 Jan 2025
The first study I’ve seen with enough data to be powered to do this. A non-candidate driven observational study of effects of GLP-1s.
22 Jan 2025
Let's start with the good news. GLP1ras were associated with protean benefits (in addition to weight loss): less infection, less schizophrenia, less suicide, less lung disease, less alcohol use disorder, less acute kidney injury (#blesstheirhearts).
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Jim retweeted
19 Jan 2025
1/ This internal 2007 Nokia presentation on the first iPhone is a really good example of how incumbents actually get disrupted
Oftentimes, the incumbent already knows what needs to be done. It's just that organizational incentives inhibit the incumbent from doing it
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29 Dec 2024
Great write up. campbellramble.ai/p/convert-…
A recurring theme: “In trying to protect retail investors, the SEC has inadvertently funneled them into a potentially much riskier product”
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17 Nov 2024
I don’t know SQL well enough to do that, but I’ve definitely done some ETL in pure SQL when I didn’t want to bother writing it in python…
The most bizarre coding interview I've ever done was at Facebook when as usual I asked a candidate to write in any language of their choice..
And they nonchalantly said "I'll write it in SQL", to which I almost let loose a chuckle until...
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16 Nov 2024
A possible trajectory
16 Nov 2024
This chart is frightening.
In 1975, inflation peaked near 12% and fell in 1976 toward 4%.
When charted with the path of inflation from 2020 until now, it looks almost identical.
You can see the recent uptick in inflation below.
Are we setting up for a 1980 style rebound?
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16 Nov 2024
Annualized returns of such a trajectory
21 Apr 2016
@MebFaber If you're a fan of the long LONG term, Kondratiev wave theory says 2035 may be *very* interesting...
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18 Oct 2024
It’s curious how many markets have flipped from “buy” to “rent” now that interest rates are above 0. Housing. Cars. GPUs.
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18 Oct 2024
Biggest factor vs other “picks and shovels” markets is probably obsolescence risk and the shape of the depreciation curve. GPUs depreciate pretty rapidly as newer models come out, similar to Bitcoin miners.
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