Building @imageassist @signal21btc Investing @gossamercap Previously @googlecloud @spacioushq (acq WeWork) MS MolBio/MBA

Joined January 2008
197 Photos and videos
The era of systems managers begins
CEO of Microsoft AI Mustafa Suleyman joins FT editor Roula Khalaf to explain why most of the tasks accountants, lawyers and other professionals currently undertake will be fully automated by AI within the next 12 to 18 months ft.trib.al/SZ4Lti1
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Jonathan Sadlowe retweeted
Strong start of 2026 for $STX Chart shows the $STX strength relative to $BTC
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Jonathan Sadlowe retweeted
Your job as a startup founder is to find ways to innovate on distribution strategy as much as you innovate on product strategy.
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This is huge! Borrow against your BTC with USDC on @Stacks Stacks is making tremendous progress!
18 Nov 2025
gm @circle 🟠 Circle’s first move into Bitcoin DeFi is happening on Stacks, the only Bitcoin Layer 2 in their pilot launch of Circle xReserve. Circle xReserve is enabling Stacks to bring a USDC-backed stablecoin to Bitcoin DeFi.
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Amazing opportunity for a finance leader that can innovate at the intersection of tradfi and bitcoin/crypto 👇
HIRING 1/ gm, we are hiring a Chief Investment Officer (CIO). A future CIO's mission is to build a resilient, performance-driven treasury that funds ecosystem development, ensures liquidity for STX, and creates enduring value for the community. Link and details in the following tweet
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The best NYC mayor endorses Cuomo and I couldn’t agree more
Four months ago I endorsed @AndrewCuomo because I thought his management experience and government know-how made him the best choice for New Yorkers. I still do. And today, with early voting underway, I wanted to reiterate my support for Andrew Cuomo. Being Mayor of New York City is the second toughest job in America, and the next mayor will face immense challenges. Andrew Cuomo has the experience and toughness to stand up for New Yorkers and get things done. I hope you will join me in supporting him.
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Jonathan Sadlowe retweeted
Bitcoin treasuries will need to earn yield on their capital to stay competitive. With Dual Stacking, BTCFi, yield vaults and more, Stacks is bringing real yield to Bitcoin. Stacks is preparing itself to be the go-to ecosystem for treasuries and whales to earn BTC yield.
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Exciting for the @Stacks ecosystem!
GM! This week starts the official beginning of the Stacks Endowment. With the approval of SIP-031, our charter is to manage and grow the long term treasury of @Stacks. This week, we made our first deployment into @VelarBTC based on community feedback. Like a true DeFi degen, we took out loans against the treasury through @ZestProtocol to acquire the necessary assets to add liquidity to Velar Perps. We’re bullish on activating the flywheel economy in our ecosystem. In the very near future, you'll see us actively funding Grants, providing liquidity, fueling key integrations, and deploying capital in the Stacks DeFi ecosystem, all in partnership with the Treasury Committee and other key contributors. More to come soon🟧
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I'm humbled and excited to be selected for the @Stacks Treasury Committee! 🫡 I truly believe Stacks has the potential to transform the Bitcoin economy, and I can't wait brining my experience, skills, and network to support the growth of the ecosystem! Let's gooooo!!! 🚀
25 Sep 2025
The next era of Stacks starts now. Today we welcome the Stacks Treasury Committee. A focused group to steward the Endowment, accelerate builders, and grow the Bitcoin economy on Stacks. /🧵
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Highly thought provoking article by @AmyDMarcus as she wore a suit created by @MIT_AgeLab to simulate being 80 years old. Great insights on longevity and having empathy for the elderly. Lots of opportunities for builders in this space. wsj.com/health/wellness/mit-…
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I use this product all the time, highly recommend!
5 Sep 2025
Have you tried the @Stacks wallet tracker on Signal21? It's a great way to easily keep track of your own wallet activity and follow the activity of large $STX $sBTC $stSTX $ALEX $DIKO $USDA $USDh $aeUSDC and $VELAR holders 👀
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Jonathan Sadlowe retweeted
4 Sep 2025
Select Bitcoin Treasury data now live on Signal21 📊 Stay tuned as we expand this dataset and research!
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Dear 𝕏 Hivemind, I'm looking for an EA (executive assistant) who can also do marketing and account/customer support across multiple businesses. What are the best remote EA hiring platforms today? Thanks!
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This is a massive for @Stacks👇 "sBTC and STX will be deployed on Solana and Sui using NTT’s burn-and-mint mode, creating a unified supply that is managed and maintained across all supported chains with no wrapped tokens. This eliminates liquidity fragmentation, allowing for users to participate in Bitcoin-native DeFi on multiple chains while maintaining the security and decentralization advantages unique to the Stacks L2."
1 Jul 2025
Stacks 🤝 Wormhole $sBTC and $STX are going natively multichain with Wormhole NTT. Wormhole will integrate @Stacks to take $1.5 billion in sBTC and STX multichain, starting with @solana and @SuiNetwork.
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Really enjoyed this conversation with @longstreetBTC And be sure to follow @signal21btc for Bitcoin ecosystem data 📊
Jonathan Sadlowe @jsadlowe drops serious alpha in this episode of The Leather Lounge. From Bitcoin treasury companies to e-commerce, healthcare, and on-chain AI tools - this is a masterclass in where Bitcoin and Stacks are headed next. 03:07 Jonathan Sadlow's Background and Journey into Bitcoin 07:02 Evolution of the Bitcoin Ecosystem and Stacks 08:29 Stacks is Winning in the Bitcoin L2 Landscape 10:23 Comprehensive Demo of Signal 21 17:52 More Use Cases for Signal 21 20:51 Current Trends: Bitcoin Yield and Treasury Companies 23:58 The Potential Unwind of the Bitcoin Treasury Companies 25:37 sBTC, DeFi, Healthcare, insurance, and RWA's on Bitcoin via Stacks 28:37 E-Commerce will be a Gamer-Changer 32:17 The Problem with Stable Coins and the Need for Market Structure 34:08 Thoughts on AI and Healthcare Innovations 38:22 It's a great time to be building in Bitcoin
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I just voted YES for @stacks SIP-031 ✅ The future of Stacks is looking bigger and brighter 🚀 You can vote at stx.eco

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Jonathan Sadlowe retweeted
SIP-31 gives @Stacks the one thing it’s always lacked: a real budget to match its ambition. @jsadlowe, CEO of @signal21btc, shares why he’s voting yes, and why SIP-31 is a long-overdue catalyst to solidify Stacks as Bitcoin’s leading L2. 👇
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SIP-31 will be rocket fuel for @Stacks - I'm a YES 🚀
What happens when you combine growth capital, sharper tooling, and strategic coordination? @jsadlowe of @signal21btc breaks down why SIP-31 is a turning point for @Stacks and how the ecosystem can compete at the highest level. Stacks Unleashed Ep 05 👇 00:00 SIP-31 and Jonathan’s Background 01:01 Why Jonathan Supports SIP-31 02:38 Three Growth Priorities: Narrative, Tools & Community 06:14 The Case for Strategic Coordination 07:34 The Magnet Effect of SIP-31
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Jonathan Sadlowe retweeted
Ep 57 – On Chain Clarity with Jonathan Sadlowe of Signal21 x.com/i/broadcasts/1gqxvjgmZ…
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