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@KinatSofrim @kinatsofrim

Rabbenu Pehter - Seforim advice. NFA.

Joined March 2020
  • Tweets 8,967
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  • Followers 954
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@KinatSofrim@kinatsofrim
3 Oct 2022
For those who've asked in the DMs - Yes, 99% posted is bought (feel free to ask for pgs./opinions about spec. seforim & will try to accommodate). Strictly personal recommendations, hopes to show richness and depths of Torah & to bring to the fore lesser-known authors/titles.
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$KPTI MF timeline. P1 update at ASH Dec. 2022, then April 2023 at AACR, initiates P3 June 2023, receive FT July 2023 (received OD in Oct. 2022), Nov. 2023 CEO @ Jefferies "Very open to the possibilities to make sure that we maximize the potential of Selinexor Rux $INCY". /1
Juan P. Serrate, DVM@JPZaragoza1
8 Mar 2024
From Cantor: biotech M&A transactions took an avg of 12.9 mos in 2023. From start of deals talks to deal announcement. Assume deal talks start after data, confirming this and how long after data.
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$LLY Head of BD “And then along the way, if there are rational combinations* to do, we could consider that for sure.” @rosslevinemd $KPTI *selinexor/eltanexor fiercebiotech.com/biotech/li… /443 x.com/kinatsofrim/status/205…

Lilly unveils first clinical data behind $2.3B Ajax deal, showing JAK inhibitor works ‘right out of...

Eli Lilly’s up-to-$2.3 billion acquisition of Ajax Therapeutics is facing | Eli Lilly’s up-to-$2.3 billion acquisition of Ajax Therapeutics is facing its first major public test, and the initial...

fiercebiotech.com
@KinatSofrim@kinatsofrim
May 27
Replying to @avidresearch @harrisoncn1 @peter_mpn @KartosThera @buysidebio @Biopharmaddict @bose_prithviraj @Blood_Cancers @RaajitRampal @ByMadeleineA @LongwoodLeaders @mpnadvocacy @HealthTree @mpdrc @IcahnMountSinai @pankitvachhani @OncLive @MPN_BMTDOC @sk_tantravahi @AshKishtagari @Yi_Chai18 @CNBCFastMoney @MelissaLeeCNBC @UofUHematology @PeterKolchinsky @MPN_RF @AaronGerds @SGO_org @AACR @CIUSSS_COMTL @MDmasarova @KuykendallMd @WinshipAtEmory @t_lorriman
$LLY paid $2.3b for $AJAX Type II JAK2 for R/R MF pts who failed rux. $KPTI seli rux combo has OS HR 0.43 in FL JAKi-naive MF pts. The drugs aren't competitive rather sequential. re EC: $ACRV's prexasertib a $LLY license & $KPTI's selinexor different MoA's & different population.
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Last week at Goldman Sachs, $INCY's CEO defended 989 against $LLY's AJAX acquisition as "apples and oranges". Today, Jefferies post-EHA note calls them out. $LLY's AJAX P1 data is apples to apples but superior. /444 x.com/kinatsofrim/status/206…
@KinatSofrim@kinatsofrim
Jun 2
Replying to @harrisoncn1 @peter_mpn @KartosThera @buysidebio @Biopharmaddict @bose_prithviraj @Blood_Cancers @RaajitRampal @ByMadeleineA @LongwoodLeaders @mpnadvocacy @HealthTree @mpdrc @IcahnMountSinai @pankitvachhani @OncLive @MPN_BMTDOC @sk_tantravahi @AshKishtagari @Yi_Chai18 @CNBCFastMoney @MelissaLeeCNBC @UofUHematology @PeterKolchinsky @MPN_RF @AaronGerds @SGO_org @AACR @CIUSSS_COMTL @MDmasarova @KuykendallMd @WinshipAtEmory @JCO_ASCO @doctorpemm
$KPTI Dr. Mascarenhas effectively killed the rationale for a new pelabresib P3. Seli rux kills the clone, reduces VAF, suppresses blasts, OS... Pela has none of that. $NVS paid $2.9B (already wrote off $800mm) for an asset that just got lapped. $INCY has everything to lose. /423
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Newer vintage is still up there. A presence, weight and flavor; not the pretentious type you need to toy with to see if you like it or convince yourself that you do. Makes the ועל פרי גפנהּ more meaningful. #KSbottles
@KinatSofrim@kinatsofrim
16 Feb 2024
Gantz fein #KSbottles
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Coming in at ~$10 they’re both great bang for your buck; Cabernet easily being as good as a $20. Merlot was humble for its price but the type who’s clearly a baal kishron and pleasant company. Cab was a young charif and lamdan with what to offer and makes you smile #KSbottles
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New ספר לב אברהם על הש"ס from Rav Avraham Mimun ztl
@KinatSofrim@kinatsofrim
11 Jun 2024
New שו"ת לב חנון volume 3 from Rav Avraham Mimun ztl
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Bros shuffling x.com/PolymarketStory/status…

Polymarket Sports
@PolymarketSport
Jun 9
🚨BREAKING: Someone named ‘JewishNjnja’ just put $1.5M on the Knicks to win game 3 tonight… This massive trade cashes $2,829,390.74 on Polymarket
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$KPTI Thank you @huang_lab "Discovery, Validation and Mechanistic Study of XPO1 [selinexor] Inhibition in the Treatment of Triple-Negative Breast Cancer" @Stemline @genentech @FoundationATCG @Roche mdpi.com/2072-6694/16/23/398…
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$KPTI x.com/ThailandMedicaX/status…

Thailand Medical News
@ThailandMedicaX
22 Oct 2025
Replying to @ThailandMedicaX
when used together, the combination killed nearly 75% of cancer cells, compared to about 45% for selinexor alone. The strongest effects were seen in the HCC-1806 cell line, which mimics some of the most resistant TNBC cases.
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👆🏽 x.com/adamfeuerstein/status/…

Adam Feuerstein ✡️
@adamfeuerstein
Jun 8
$GILD $MRK discontinued the Trodelvy-Keytruda EVOKE-03 study in lung cancer due to weak PFS. A sac-TMT competitor falls off. merck.com/news/merck-and-gil…
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Me when the rebbe says “come make a l’chaim so we can bring down the oros and be a keli to -…”
NANA♥️
@__________Nadia
Jun 5
This is really funny😂😂😂
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A toast over kiddush to @minhagim’s complete & speedy recovery: Tasted plush cherries stewed on a heated gym mat, light peppercorn, cantaloupe; body-wise like a cross of silk pajamas and israeli bottled water. Worth the couple extra dollars #KSbottles
minhagim@minhagim
May 27
Replying to @kinatsofrim @endimem_music
Stick to wine please. Your (2nd) best tweets.
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