Data Scientist, Patent owner of Artificial Intelligence-assisted methodology for Medical Discovery. Tweets are mine/not medical advice or endorsements.
Joined May 2009
- Tweets 2,337
- Following 2,927
- Followers 4,961
- Likes 3,592
483 Photos and videos
Pinned Tweet
1) Using a state-of-the art #AI committee (=multiple reasoning #AI engines investigating the same problem) we have two new #MECFS and #LongCOVID research targets being confirmed : a) Phosphoinositide-controlled membrane identity b) The role of RAB Proteins and prenylation.
2
2
13
812
Efthymios Kalafatis retweeted
We're just about done with healthy volunteers but we still need a handful of people with pre-covid ME/CFS, and quite a few more people with Long COVID
This is for 1-200 people sized cohorts across multiple biological studies
Screening and contact form below👇(info not retained)
Still doing home visits for research into:
-platelet activation
-miRNAs
-cellular metabolism
-immune function
in pw/ ME/CFS or w/ Long COVID🩸🔬
If you're a woman with ME/CFS or Long COVID in VIC, Aus want to be contacted, please fill in this form: redcap.latrobe.edu.au/redcap…
5
41
80
4,290
Efthymios Kalafatis retweeted
Read this #preprint on @researchsquare: Biological Insights from Genome-Wide Association Studies and Whole Genome Sequencing of Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome researchsquare.com/article/r…
7
25
91
11,060
Efthymios Kalafatis retweeted
May 15
1) 🇪🇸 A new Spanish study measured autoantibodies against adrenergic and muscarinic receptors in 59 patients with ME/CFS, 96 Long Covid and 36 healthy controls.
The results show a large overlap, questioning whether these antibodies are involved in ME/CFS pathology.
ALT Graph showing large overlap in adrenergic and muscarinic autoantibodies between ME/CFS patients, Long Covid patients, and healthy controls.
10
33
97
10,353
Efthymios Kalafatis retweeted
YESSS!!!! Congrats Chris Ponting and team
May 11
Great news from the UK🍾
ÂŁ4.75 million to do whole-genome sequencing on 6000 DecodeME samples
thetimes.com/uk/healthcare/a…
(paywall)
Unfortunately it's not enough to analyse the full sample
People can find out more about SequenceME & donate here
megenetics.org.uk/our-projec…
#MEcfs #PwME
ALT Landmark ME study will map patients’ DNA in mission to find cure The government will provide £4.75 million in funding to British scientists who aim to create a test to reliably identify chronic fatigue syndrome new Maeve Boothby O’Neill died in 2021 from malnutrition caused by severe MEPA Oliver Wright, Policy Editor, and Kaya Burgess, Science Correspondent Monday May 11 2026, 10.15pm BST, The Times Listen • 4:24 min Share Prefer us on Google Thousands of patients suffering from chronic fatigue syndrome are to have their full genetic codes mapped in an attempt to find a cure for the debilitating and mysterious illness. The study, a world first for the syndrome also known as myalgic encephalomyelitis (ME), will be funded by an investment of £4.75 million from the government in the hope that it will lead to a test to reliably identify the illness and eventually develop drugs to treat it for the first time.
7
23
112
2,099
1) Using a state-of-the art #AI committee (=multiple reasoning #AI engines investigating the same problem) we have two new #MECFS and #LongCOVID research targets being confirmed : a) Phosphoinositide-controlled membrane identity b) The role of RAB Proteins and prenylation.
2
2
13
812
2) Input data used : Genomics, eQTL colocalisation, gene-network analysis, metabolomics, lipidomics, proteomics, extracellular-vesicle proteomics, immune phenotyping, ion-channel functional assays, biomarker assays, exercise-challenge omics, and computational metabolic modelling.
1
5
310
3) Efferocytosis is still an important factor for Post Exertional Malaise (hypothesis) and complements the proposed research targets discussed in the first post. Findings of -consistently- elevated CD24 may be causing impaired efferocytosis (hypothesis)
1
1
6
476
Efthymios Kalafatis retweeted
Apr 14
I want to ask you to follow this dot with your eyes. Was that easy? Without you even having to give that much thought, your brain is telling your eye muscles where to move to keep your focus on that dot. 1/
21
86
370
86,442
1/ After all of these years, I forgot about the importance of zinc. If you are an #MECFS, #LongCOVID patient and especially if you are male, do look at your zinc levels. Important for CYP11A1 (P450scc). Below, snapshot from my presentation at @LSHTM (2018)
1
8
33
1,292
2/ Caution : zinc supplementation inhibits copper. Make sure you do any supplementation under specialist guidance.
2
8
351
Efthymios Kalafatis retweeted
Mar 22
1/ I want to explain a bit about our MIT MAESTRO study. 🧵How can we help you get better if we don't know what's making you sick? If we don't currently have a way to identify what's going wrong, and we don't have the right tests, I think we need to MEASURE ABSOLUTELY EVERYTHING.
16
47
228
43,835
1/ What I experienced with the use of SPMs (Pro resolving mediators) is simply amazing. The idea was to use SPMs for improving efferocytosis. I do not have any #MECFS symptoms so I can't tell anything about improvements but a lower back pain I had for over 2 months...
2
1
16
1,111
2/ .. (lately I was finding it hard to sit in my car for more than 10 minutes) went away literally in 4 days of SPM supplementation. Initially, I changed my mattress to a harder one and saw roughly a 10% improvement. It appears that SPMs were a game changer.
1
6
425
3/ Please note, I am in no position to be certain or make any claims that SPMs are responsible for this change but I felt I had to report this.
3
7
358
Efthymios Kalafatis retweeted
Mar 14
We are one person away from completing our sex and age matching for our MAESTRO study! One 56-65 year old male with long COVID who can come to MIT in person and this first chapter of MAESTRO will be complete!!!
20 Dec 2025
2/ MAESTRO: Measure Absolutely Everything So Tests can be Reliable and Objective!
We have ways to measure and put hard numbers on features of neurological dysfunction; we don't need to say that 'brain fog' is a subjective symptom that we don't have a way to measure anymore.
4
40
78
10,130
3/ It appears that Fucoidan matches with many key aspects that are important for proper efferocytosis. ABCA1, LXR, GAS6 / MerTK are regulated by Fucoidan (all these concepts were found by studies - see previous post). Some relevant studies regarding fucoidan shown below :
1
5
558
4/ It is also possible that an approach using multiple compounds is needed for better results, for example Fucoidan Pro-resolving mediators (SPMs) and/or PPAR agonists. Moreover Fucoidan could be -according to AI below (may contain errors) - a compound to improve Fibrinolysis.
1
5
621
5/ Disclaimer : This thread DOES NOT suggest in any way to supplement with Fucoidan, SPMs, or PPAR Agonists. Talk to your Doctor before any intervention ! Further research is needed as to whether these compounds are indeed beneficial to patients !
2
5
439
1/ Finally I can share this : I propose the investigation of Fucoidan (LMWF) using a RCT for the amelioration of Post Exertional Malaise -and possibly of other symptoms- of #MECFS and related syndromes. Here is why (make sure you read Disclaimer at end of thread) :
8
7
45
3,820
2/ In previous posts, I shared that efferocytosis is becoming more relevant as more results from studies are coming in. At the time of this post here is how it looks like with relevant studies . Link to the file : docs.google.com/spreadsheets…
1
3
521