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Max Valenstein, MD, PhD @mlvalenstein

@MGHMedRes Stanbury PSP @MGHMedicine | Alum @HarvardMITMDPhD @HarvardMed @MIT_HST @MITBiology @Yale @YaleMBB

Joined November 2014
  • Tweets 36
  • Following 167
  • Followers 238
3 Photos and videos
Congratulation to @DrMartyTaylor et al! Grateful to have played a small part in this
Marty Taylor, MD PhD@DrMartyTaylor
1 Dec 2025
How can the same "master regulatory" protein mTOR recognize different sets of targets to separate nutrient and growth factor signals? Thrilled to share our new paper, in which we reveal how mTORC2 recognizes Akt. 🧵 on our new paper in Science: science.org/doi/10.1126/scie…
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Thanks @chivukula_raghu! Now, back to being the Bigelow JAR...
Raghu Chivukula, MD PhD 🫁🧬🧠@chivukula_raghu
20 Aug 2025
Yet another beautiful piece of structural and biochemical work led by by friend, colleague, and @MGHMedicine resident @mlvalenstein! Thrilled to have contributed in a small way to this important study. Congrats to @plalgudi11, @DMSabatini, Kacper, et al. nature.com/articles/s41586-0…
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nature.com/articles/s41586-0…

Structural basis for the dynamic regulation of mTORC1 by amino acids

Nature - Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers...

nature.com
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Please check out the beautiful videos, rendered by Kacper, that bring these proteins to life!
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A special shoutout here to @plalgudi11, seen here helping to spot *the grids* almost four years ago to the day at MIT!
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Grateful to have contributed a (very) small part to this fantastic work. Congratulations to @jason_yang0, @chivukula_raghu, et al!
Raghu Chivukula, MD PhD 🫁🧬🧠@chivukula_raghu
21 Jul 2025
Replying to @chivukula_raghu
This work was led by @jason_yang0 (now @BrunetLab) and aided by a talented and hardworking team: Forrest Xu, David Ziehr, @DrMartyTaylor @mlvalenstein @genfren Jack Bush, Kate Rutter, Igor Stevanovski, @CharlieYShi Mahesh Kesavan, @RMouroPinto @IDeveson David Bartel @DMSabatini
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In this week’s @Nature, we report that nutrients do not activate mTORC1 through degradation of GATOR1 component DEPDC5. Other molecular events signal the presence of amino acids to this essential growth pathway! nature.com/articles/s41586-0…
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Max Valenstein, MD, PhD retweeted
Mass General Brigham Research@MGBResearchNews
4 Oct 2024
In a new study published in @PNASNews, researchers from @MGHMedicine and colleagues investigated how cells sense and respond to the presence of nutrients. Read more: massgeneral.org/news/researc… @mlvalenstein @chivukula_raghu @DMSabatini
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Out in @PNASNews now, we find that the Rag-Ragulator heptamer anchors the GATOR supercomplex to the lysosome. Our results highlight the complex role the Rags play in regulating mTORC1 activation and lysosomal homeostasis (1/2)
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It will be exciting to explore how they function in specific lysosomal and lysosome-related compartments. Congrats to all involved, particularly @plalgudi11 and @XinGu0317! Read more here: pnas.org/doi/10.1073/pnas.23… (2/2)
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Max Valenstein, MD, PhD retweeted
Jose Florez@JoseFlorezMDPhD
16 Aug 2024
The @mghmedres Stanbury program attracts and trains top physician-scientists. At this year's summer retreat, @MGHMedicine family member @RWalensky shared her insights on matters relevant to her tenure as @CDCgov Director.
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You catch more flies with leucine! Congratulations to @XinGu0317 and team for revealing that nutrient sensing by mTORC1 influences dietary choices in Drosophila! Read it to see what the buzz is all about!🪰🍎 nature.com/articles/s41586-0…

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Max Valenstein, MD, PhD retweeted
Lasker Foundation
@LaskerFDN
19 Jul 2022
The GATOR2 protein complex senses leucine and arginine, keeping track of nutrient abundance in a cell’s environment. The newly resolved #cryoEM structure reveals that GATOR2 uses distinct surfaces to sense these two amino acids in parallel. @mlvalenstein ow.ly/Bb6i50JYBgk
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Excited and grateful to share this with the world! Our structure of the mysterious GATOR2 complex sheds light on the ways that mTORC1 receives and integrates nutrient signals. Thank you to everyone who contributed to this work! 🐊🐊
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Max Valenstein, MD, PhD retweeted
Whitehead Institute@WhiteheadInst
13 Jul 2022
Out now in @Nature: former Whitehead Institute researchers @mlvalenstein and @kbrogala solve the 3D structure of GATOR2, a protein complex that plays a key role in regulating cell growth: wi.mit.edu/news/form-follows…
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Made it to the top! Waiting on @LorenWalensky @HarvardMITmdphd
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Relatable x.com/mattzap/status/9913800…

Matt Zapotosky@mattzap
1 May 2018
BREAKING: Rod Rosenstein says at @Newseum event that both common pronunciations of his last name are acceptable. He pronounces it "stine," with a long i, but some family members pronounce it "steen," with a long e.
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Max Valenstein, MD, PhD retweeted
Hank Adelmann@hankadel
27 Oct 2017
In honor of 25 years of mTOR we reorganized the lab antibody box... Is this still good? @DMSabatini @mlvalenstein @JoseMOrozco @kendyjco
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