A terrific perspective from Ivan Dikic linkedin.com/feed/update/urn…)

Important and provocative paper for those of us hoping to use machine learning to determine small molecule structures from raw LC-MS/MS spectra. @BarzilayRegina @NatMetabolism nature.com/articles/s42255-0…

For a variety of reasons, we’ve been quantitating many western blots & radioactive protein gels so made this app for doing so as unhappy with what is available. Can quickly quantitate gels/blots & make simple graphs from the data. Instruction tab in app. dms-western-blot-analyzer.ne…

Congratulations to the 13 winners of this year’s @psscra Cancer Prize! Some fantastic people there. These days we depend even more on philanthropy to support high caliber research …#cancer #research

Excited to share our new paper out today in @NatureMetabolism! "Hyperglycosylation is a metabolic driver of Alzheimer’s disease" *We bridged spatial metabolomics (MALDI-MSI glycomics lipidomics isotopic pulse-chase tracing) directly to experimental biochemistry (genetic knockdown of glycan enzymes glucosamine supplementation in AD models) and real-world public health data (EHR analysis showing glucosamine use linked to faster MCI-to-AD progression and worse survival). **Key takeaway: The AD brain shows conserved hyperglycosylation driven by ramped-up glycan biosynthesis — not just a byproduct, but a causal driver. Reducing it helps cognition; boosting it (e.g., via glucosamine) worsens outcomes. ***We applied cutting-edge spatial tech to functional validation and clinical translation. Full open-access paper: nature.com/articles/s42255-0… Huge thanks to the incredible team, collaborators (incl. Matt Gentry, Stefan Prokop, @ji0ngbi0n , Yi Guo, @lichenbiostat, Ralph Deberardinis & others), and the patients/families who make this work possible.

Some really interesting nuggets being dropped at @americanaging days 2 and 3. Here's one: a metabolomic study in mice finds many metabolites that change consistently with age across tissues and in specific tissues. NAD and NAD metabolites are not among them. What excuse will the NAD apologists use to explain this away?

Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq

1/n Are biological neurons linear-nonlinear computers, like perceptrons, or is their output governed by non-linear interactions between inputs? If the activity of a neuron is well fit by linear models that sum inputs, does that mean that the neural computation actually is linear?

Lost their Harleys

Checkout our work published today in @NatureCancer done @BostonChildrens and led by Dr. Alan Wong rdcu.be/fkAS0

Congratulations to Dr. Shimaa Soliman and colleagues in our @ShilatifardLab as they performed detailed biochemical studies of chromatin and RNAPII under normoxic and hypoxic conditions and identified hypoxia-responsive transcriptional axis linking P-TEFb, BHLHE40, and nuclear-localized Tim8–Tim13 complexes. Our study shows that chromatin-associated interaction is required for efficient hypoxic gene transcription and operates at least partly independently of canonical HIF signaling. Disrupting Tim8–Tim13 or silencing BHLHE40 impairs acute hypoxia responses. These findings identify a new regulatory mechanism coordinating RNAPII pause release during hypoxic stress. #Hypoxia #Transcription #CancerBiology #RNApolII #PTEFb @NU_BMG_SQE @CellPressNews @ScienceMagazine @ScienceAdvances @Nature @NatMetabolism @MolecularCell @NUFeinbergMed science.org/doi/10.1126/scia…

Congratulations to Chandel lab for demonstrating that a metabolite once considered purely “toxic” may actually be a key signaling molecule in cells and organisms. This study demonstrates that l-2-HG functions in signaling by regulating epigenetic state via KDM4/H3K9me3 demethylase and linking redox state to transcriptional repression. The study provides initial words in “Metabolic Language” of transcription. nature.com/articles/s41586-0… @NU_BMG_SQE @NUFeinbergMed @Nature @CellPressNews @ScienceMagazine @MolecularCell @theNASciences @theNAMedicine @NorthwesternU @NatMetabolism

Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite nature.com/articles/s41586-0…

Excellent piece by Rick Born on a path to reforms of science funding. open.substack.com/pub/hxstem…

Interesting idea and tool

We are thrilled to announce the 13 winners of the 2026 Pershing Square Sohn Cancer Prize. Doubling our commitment, this year's scientists have been selected for their bold ideas and potential to transform cancer research. Please join us in congratulating: pershingsquarephilanthropies…

New out this week from our lab in @NatMetabolism. We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive rebound effect mediated by succinate impairing pyrimidine synthesis. nature.com/articles/s42255-0…

The franchise continues in 2026. 67 years on the market and we still wonder how metformin works. Congrats to Nav and team nature.com/articles/s42255-0…

Someone having fun with mTOR antibody labelling

Thank you Dr. Navdeep Chandel from @NUFeinbergMed for visiting us, for a fantastic lecture on mitochondrial biology and signaling, and for a very exciting and stimulating conversation as part of this month’s Cutter Distinguished Lecture series 🧿🧿