372. Advances in Polydopamine-Based Nanoplatforms: Antioxidant Mechanisms and Applications in Oxidative Stress-Mediated Diseases
Zhilin Wang, Zhu Liu, Luming Song, Xinyi Zhao, Shuaipeng Feng, Donghua Di, Hao Ju*, Long Wan* & Qinfu Zhao*
Nano-Micro Lett. 18, 372 (2026).
doi.org/10.1007/s40820-026-0…
This work is led by Prof. Dr. Qinfu Zhao (Shenyang Pharmaceutical University) and co-workers. Prof. Zhao’s research centers on construction of targeted nano-diagnostic and therapeutic agents and study of their mechanism of action, application research of novel biomaterials in chronic inflammatory diseases, applied basic research of new drug formulations and new preparations. This review provides a comprehensive overview of polydopamine (PDA)-based antioxidant nanoplatforms, summarizing their ROS-scavenging mechanisms (hydrogen atom transfer, electron transfer, and dynamic catechol/quinone redox cycling) and the design strategies of various architectures (solid, mesoporous, hollow, doped, and coated). It further categorizes recent progress in addressing key pathological challenges, including breaking ROS-inflammation feedback loops, overcoming biological delivery barriers, remodeling regenerative microenvironments, and regulating programmed cell death.
#PDA
#antioxidant
#ROS
#nanoplatform
#redox