An online resource for researchers studying and using organoids. Part of the @STEMCELLTech Science News service.
Joined September 2017
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Investigators develop a 3D multi-spheroid neuronal model that better mimics cellular differentiation and shows greater resilience to toxic insults than conventional 2D cultures.
Learn more at @SciReports:
go.nature.com/4uv9OmI
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Scientists alongside Dr. Anna Golebiewska summarize the diverse protocols currently used for glioblastoma #organoid derivation and long-term maintenance, focusing on the recapitulation of microenvironmental traits.
🔓 #OpenAccess
🔖 bit.ly/4eCkIm3
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Jun 11
Gravity variations on the activity of neuronal #spheroids!
Researchers show that changes in gravity alter neuronal activity in 3D neural spheroids, demonstrating the potential of acoustic trapping platforms for studying brain function in microgravity.
▶️ go.nature.com/4vHecAd
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. @biosymetrics and @BrainstormCell have launched a grant-funded collaboration combining AI, zebrafish models, and human #BrainOrganoids to identify and validate new drug targets for neurological diseases such as rare epilepsies and Parkinson’s disease. 🧠
Learn more: bit.ly/3PRGYPz
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Deconstructing cancer in 3D!
Scientists highlight how advanced 3D cancer models, from #organoids and spheroids to organ-on-a-chip systems and 3D bioprinting, are reshaping cancer research. 🧫
Discover more here:
🔖 bit.ly/43jkWbt
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Scientists established and clinically validated liver cancer organoids that faithfully replicate patient tumors and their drug response profiles.
Learn more here:
bit.ly/4vxFzg5
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Scientists leveraged #organoid technology and NanoSeq duplex sequencing to uncover distinct mutational patterns associated with known carcinogens. @CellReports
Learn more here:
📝 bit.ly/4uOOBoN
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Researchers show that necroptosis triggers inflammatory interferon responses in metastatic breast cancer #organoids, highlighting a potential strategy to overcome therapy resistance and enhance anti-tumor immunity.
go.nature.com/4ufoR41
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May 29
Drs. Huan Chen and Hongwei Hou established an #hPSC-derived airway #organoid platform and compared the toxicological profiles of two heated tobacco product aerosols. bit.ly/3REAAvm
They establish human-derived airway organoids as a sensitive, human-relevant platform for qualitative comparison and mechanistic interrogation of product-specific toxicity. 🧫
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May 29
Assembloids: The next dimension in #organoid research. 🧫
This review shines a light on a new step in organoid research: building “assembloids” by combining multiple organoids or specialized cells into one 3D system.
💡Learn more in @CellBiomat: bit.ly/4ag8iO5
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May 28
Scientists with @KarunaMDPhD at @MSKCancerCenter establish an #organoid orthotopic intraperitoneal xenograft model that recapitulates diffuse peritoneal carcinomatosis (PC).
🔗: bit.ly/4wYZHJG
📓: @Dev_Cell
PC organoids retain increased metastatic capacity and decreased sensitivity to standard-of-care chemotherapy relative to matched primary appendiceal adenocarcinoma organoids. 🧫
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May 27
Learn more about #SkinOrganoids, including primary skin organoids, tissue-engineered skin, and PSC-derived organoids in @CellBiomat!
📖 bit.ly/4eaKsor
The authors emphasize challenges, including the absence of fully developed vascular and immune systems in most skin organoid models, along with issues with standardization and reproducibility.
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May 26
Scientists from Central South University discuss #organoid generation strategies, mainly dividing them into scaffold-free and scaffolded methods, and details specific generation protocols for brain, liver, intestine, kidney, and bone organoids. 🦴🧠
bit.ly/3Pn5S9t
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May 23
Researchers developed a new multilayered microelectrode platform that can monitor neural activity throughout cerebral #organoids, improving long-term recording of 3D brain-like networks for neuroscience research and drug testing.
🔖 go.nature.com/4f8a9rP
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May 22
Researchers developed stretchable microelectrode arrays with microneedles for stable, minimally invasive electrophysiological recording of human heart and brain #organoids.
Learn more here:
🔖 bit.ly/3Rj9cTD
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May 21
In this review, the authors highlight how kidney #organoids are advancing disease modeling, drug discovery, and regenerative medicine for chronic kidney disease.
Read more here:
▶️ bit.ly/4fEdVcm
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May 20
Researchers show that targeting YAP-mediated stromal signaling overcomes fibrosis-driven chemoresistance, enabling near-complete tumor eradication in a human #organoid model.
Discover more here:
🔗 bit.ly/4dukzkl
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May 18
Researchers developed a robust engineered cuboid chip platform to generate distal respiratory airway #organoids from human pluripotent stem cells with enhanced efficiency and maturity.
▶️ bit.ly/4tAw6mA
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